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Journal Abstract Search

757 related items for PubMed ID: 8894513

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  • 3. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
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  • 5. Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
    Yang Z, Zadjura L, D'Arienzo C, Marino A, Santone K, Klunk L, Greene D, Lin PF, Colonno R, Wang T, Meanwell N, Hansel S.
    Biopharm Drug Dispos; 2005 Dec; 26(9):387-402. PubMed ID: 16142720
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  • 9. Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies.
    Prueksaritanont T, Gorham LM, Ellis JD, Fernandez-Metzler C, Deluna P, Gehret JR, Strong KL, Hochman JH, Askew BC, Duggan ME, Gilbert JD, Lin JH, Vyas KP.
    Drug Metab Dispos; 1996 Nov; 24(11):1263-71. PubMed ID: 8937862
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  • 12. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
    Kuperman AV, Kalgutkar AS, Marfat A, Chambers RJ, Liston TE.
    Drug Metab Dispos; 2001 Nov; 29(11):1403-9. PubMed ID: 11602515
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  • 13. Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.
    Iwatsubo T, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Nov; 283(2):462-9. PubMed ID: 9353358
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  • 14. Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A.
    Chiba M, Hensleigh M, Lin JH.
    Biochem Pharmacol; 1997 Apr 25; 53(8):1187-95. PubMed ID: 9175724
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  • 15. Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.
    Kumar S, Samuel K, Subramanian R, Braun MP, Stearns RA, Chiu SH, Evans DC, Baillie TA.
    J Pharmacol Exp Ther; 2002 Dec 25; 303(3):969-78. PubMed ID: 12438516
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  • 18. Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical species and human.
    Frederick KS, Maurer TS, Kalgutkar AS, Royer LJ, Francone OL, Winter SM, Terra SG, Chen D, Gao X.
    Xenobiotica; 2009 Oct 25; 39(10):766-81. PubMed ID: 19622022
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