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151 related items for PubMed ID: 8910319

  • 1. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
    McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM.
    J Biol Chem; 1996 Nov 01; 271(44):27402-7. PubMed ID: 8910319
    [Abstract] [Full Text] [Related]

  • 2. CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
    McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD.
    Biochem Biophys Res Commun; 1995 Sep 05; 214(1):295-303. PubMed ID: 7669049
    [Abstract] [Full Text] [Related]

  • 3. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.
    Carloni V, Pinzani M, Giusti S, Romanelli RG, Parola M, Bellomo G, Failli P, Hamilton AD, Sebti SM, Laffi G, Gentilini P.
    Hepatology; 2000 Jan 05; 31(1):131-40. PubMed ID: 10613738
    [Abstract] [Full Text] [Related]

  • 4. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P.
    Am J Physiol; 1998 Jul 05; 275(1):L55-63. PubMed ID: 9688935
    [Abstract] [Full Text] [Related]

  • 5. Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity.
    McGuire TF, Sebti SM.
    Oncogene; 1997 Jan 23; 14(3):305-12. PubMed ID: 9018116
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
    Finder JD, Litz JL, Blaskovich MA, McGuire TF, Qian Y, Hamilton AD, Davies P, Sebti SM.
    J Biol Chem; 1997 May 23; 272(21):13484-8. PubMed ID: 9153192
    [Abstract] [Full Text] [Related]

  • 7. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
    Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM.
    Oncogene; 1996 Nov 07; 13(9):1991-9. PubMed ID: 8934546
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep 07; 15(11):1283-8. PubMed ID: 9315095
    [Abstract] [Full Text] [Related]

  • 9. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
    Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26802-6. PubMed ID: 7592920
    [Abstract] [Full Text] [Related]

  • 10. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
    Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1997 Oct 24; 272(43):27224-9. PubMed ID: 9341167
    [Abstract] [Full Text] [Related]

  • 11. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1998 Mar 24; 16(11):1467-73. PubMed ID: 9525745
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
    Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM.
    J Biol Chem; 2002 May 03; 277(18):15309-16. PubMed ID: 11839765
    [Abstract] [Full Text] [Related]

  • 13. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26770-3. PubMed ID: 7592913
    [Abstract] [Full Text] [Related]

  • 14. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.
    Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B.
    J Biol Chem; 2001 Apr 20; 276(16):12805-12. PubMed ID: 11278505
    [Abstract] [Full Text] [Related]

  • 15. Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells.
    Ownby SE, Hohl RJ.
    Lipids; 2002 Feb 20; 37(2):185-92. PubMed ID: 11908910
    [Abstract] [Full Text] [Related]

  • 16. Effect of farnesyltransferase overexpression on cell growth and transformation.
    Nagase T, Kawata S, Nakajima H, Tamura S, Yamasaki E, Fukui K, Yamamoto K, Miyagawa J, Matsumura I, Matsuda Y, Matsuzawa Y.
    Int J Cancer; 1999 Jan 05; 80(1):126-33. PubMed ID: 9935242
    [Abstract] [Full Text] [Related]

  • 17. Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).
    Ahn HY, Hadizadeh KR, Seul C, Yun YP, Vetter H, Sachinidis A.
    Mol Biol Cell; 1999 Apr 05; 10(4):1093-104. PubMed ID: 10198059
    [Abstract] [Full Text] [Related]

  • 18. Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor.
    McGuire TF, Corey SJ, Sebti SM.
    J Biol Chem; 1993 Oct 25; 268(30):22227-30. PubMed ID: 7693661
    [Abstract] [Full Text] [Related]

  • 19. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells.
    Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A, Reuter CW.
    Br J Haematol; 2005 Sep 25; 130(6):912-25. PubMed ID: 16156861
    [Abstract] [Full Text] [Related]

  • 20. MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling.
    Graham TE, Pfeiffer JR, Lee RJ, Kusewitt DF, Martinez AM, Foutz T, Wilson BS, Oliver JM.
    J Immunol; 1998 Dec 15; 161(12):6733-44. PubMed ID: 9862703
    [Abstract] [Full Text] [Related]

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