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Journal Abstract Search

154 related items for PubMed ID: 8917647

  • 1. Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
    Hutchinson JH, Cook JJ, Brashear KM, Breslin MJ, Glass JD, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Sitko GR, Stranieri MT, Hartman GD.
    J Med Chem; 1996 Nov 08; 39(23):4583-91. PubMed ID: 8917647
    [Abstract] [Full Text] [Related]

  • 2. New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: orally active series of N-alkylated amidines with a 6,6-bicyclic template.
    Okumura K, Shimazaki T, Aoki Y, Yamashita H, Tanaka E, Banba S, Yazawa K, Kibayashi K, Banno H.
    J Med Chem; 1998 Oct 08; 41(21):4036-52. PubMed ID: 9767641
    [Abstract] [Full Text] [Related]

  • 3. In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.
    Prueksaritanont T, Gorham LM, Breslin MJ, Hutchinson JH, Hartman GD, Vyas KP, Baillie TA.
    Drug Metab Dispos; 1997 Aug 08; 25(8):978-84. PubMed ID: 9280406
    [Abstract] [Full Text] [Related]

  • 4. New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent.
    Badorc A, Bordes MF, de Cointet P, Savi P, Bernat A, Lalé A, Petitou M, Maffrand JP, Herbert JM.
    J Med Chem; 1997 Oct 10; 40(21):3393-401. PubMed ID: 9341914
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.
    Mehrotra MM, Heath JA, Smyth MS, Pandey A, Rose JW, Seroogy JM, Volkots DL, Nannizzi-Alaimo L, Park GL, Lambing JL, Hollenbach SJ, Scarborough RM.
    J Med Chem; 2004 Apr 08; 47(8):2037-61. PubMed ID: 15056002
    [Abstract] [Full Text] [Related]

  • 6. Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.
    Egbertson MS, Cook JJ, Bednar B, Prugh JD, Bednar RA, Gaul SL, Gould RJ, Hartman GD, Homnick CF, Holahan MA, Libby LA, Lynch JJ, Lynch RJ, Sitko GR, Stranieri MT, Vassallo LM.
    J Med Chem; 1999 Jul 01; 42(13):2409-21. PubMed ID: 10395482
    [Abstract] [Full Text] [Related]

  • 7. Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
    Weller T, Alig L, Beresini M, Blackburn B, Bunting S, Hadváry P, Müller MH, Knopp D, Levet-Trafit B, Lipari MT, Modi NB, Müller M, Refino CJ, Schmitt M, Schönholzer P, Weiss S, Steiner B.
    J Med Chem; 1996 Aug 02; 39(16):3139-47. PubMed ID: 8759635
    [Abstract] [Full Text] [Related]

  • 8. Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.
    Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD.
    J Med Chem; 1997 Jun 06; 40(12):1779-88. PubMed ID: 9191954
    [Abstract] [Full Text] [Related]

  • 9. GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
    Hayashi Y, Katada J, Harada T, Tachiki A, Iijima K, Takiguchi Y, Muramatsu M, Miyazaki H, Asari T, Okazaki T, Sato Y, Yasuda E, Yano M, Uno I, Ojima I.
    J Med Chem; 1998 Jun 18; 41(13):2345-60. PubMed ID: 9632368
    [Abstract] [Full Text] [Related]

  • 10. Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists.
    Xue CB, Wityak J, Sielecki TM, Pinto DJ, Batt DG, Cain GA, Sworin M, Rockwell AL, Roderick JJ, Wang S, Orwat MJ, Frietze WE, Bostrom LL, Liu J, Higley CA, Rankin FW, Tobin AE, Emmett G, Lalka GK, Sze JY, Di Meo SV, Mousa SA, Thoolen MJ, Racanelli AL, Olson RE.
    J Med Chem; 1997 Jun 20; 40(13):2064-84. PubMed ID: 9207948
    [Abstract] [Full Text] [Related]

  • 11. SR 121787, a new orally active fibrinogen receptor antagonist.
    Savi P, Badorc A, Lalé A, Bordes MF, Bornia J, Labouret C, Bernat A, de Cointet P, Hoffmann P, Maffrand JP, Herbert JM.
    Thromb Haemost; 1998 Sep 20; 80(3):469-76. PubMed ID: 9759629
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists.
    Carceller E, Merlos M, Giral M, Balsa D, García-Rafanell J, Forn J.
    J Med Chem; 1996 Jan 19; 39(2):487-93. PubMed ID: 8558517
    [Abstract] [Full Text] [Related]

  • 13. The effects of two synthetic glycoprotein IIb/IIIa antagonists, Ro 43-8857 and L-700,462, on platelet aggregation and bleeding in guinea-pigs and dogs: evidence that Ro 43-8857 is orally active.
    Cook NS, Bruttger O, Pally C, Hagenbach A.
    Thromb Haemost; 1993 Nov 15; 70(5):838-47. PubMed ID: 8128443
    [Abstract] [Full Text] [Related]

  • 14. Nonpeptide glycoprotein IIb/IIIa inhibitors. 15. Antithrombotic efficacy of L-738,167, a long-acting GPIIb/IIIa antagonist, correlates with inhibition of adenosine diphosphate-induced platelet aggregation but not with bleeding time prolongation.
    Cook JJ, Sitko GR, Holahan MA, Stranieri MT, Glass JD, Askew BC, McIntyre CJ, Claremon DA, Baldwin JJ, Hartman GD, Gould RJ, Lynch JJ.
    J Pharmacol Exp Ther; 1997 May 15; 281(2):677-89. PubMed ID: 9152373
    [Abstract] [Full Text] [Related]

  • 15. Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.
    Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM.
    J Med Chem; 1997 Dec 19; 40(26):4308-18. PubMed ID: 9435900
    [Abstract] [Full Text] [Related]

  • 16. Pharmacokinetics, pharmacodynamics and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administrations of a prodrug form.
    Refino CJ, Modi NB, Bullens S, Pater C, Lipari MT, Robarge K, Blackburn B, Beresini M, Weller T, Steiner B, Bunting S.
    Thromb Haemost; 1998 Jan 19; 79(1):169-76. PubMed ID: 9459344
    [Abstract] [Full Text] [Related]

  • 17. Design of a new class of orally active fibrinogen receptor antagonists.
    Klein SI, Molino BF, Czekaj M, Gardner CJ, Chu V, Brown K, Sabatino RD, Bostwick JS, Kasiewski C, Bentley R, Windisch V, Perrone M, Dunwiddie CT, Leadley RJ.
    J Med Chem; 1998 Jul 02; 41(14):2492-502. PubMed ID: 9651154
    [Abstract] [Full Text] [Related]

  • 18. Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
    Raboisson P, Desjarlais RL, Reed R, Lattanze J, Chaikin M, Manthey CL, Tomczuk BE, Marugán JJ.
    Eur J Med Chem; 2007 Mar 02; 42(3):334-43. PubMed ID: 17184884
    [Abstract] [Full Text] [Related]

  • 19. Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.
    Bednar RA, Gaul SL, Hamill TG, Egbertson MS, Shafer JA, Hartman GD, Gould RJ, Bednar B.
    J Pharmacol Exp Ther; 1998 Jun 02; 285(3):1317-26. PubMed ID: 9618439
    [Abstract] [Full Text] [Related]

  • 20. Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.
    Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA.
    J Med Chem; 1997 Aug 29; 40(18):2843-57. PubMed ID: 9288166
    [Abstract] [Full Text] [Related]

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