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83 related items for PubMed ID: 8937854

  • 1. Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
    Roy SK, Moschel RC, Dolan ME.
    Drug Metab Dispos; 1996 Nov; 24(11):1205-11. PubMed ID: 8937854
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues.
    Terashima I, Kohda K.
    J Med Chem; 1998 Feb 12; 41(4):503-8. PubMed ID: 9484500
    [Abstract] [Full Text] [Related]

  • 3. 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
    Chae MY, Swenn K, Kanugula S, Dolan ME, Pegg AE, Moschel RC.
    J Med Chem; 1995 Jan 20; 38(2):359-65. PubMed ID: 7830279
    [Abstract] [Full Text] [Related]

  • 4. Modulation of O6-alkylguanine-DNA alkyltransferase in rats following intravenous administration of O6-methylguanine.
    Dexter EU, Yamashita TS, Donovan C, Gerson SL.
    Cancer Res; 1989 Jul 01; 49(13):3520-4. PubMed ID: 2731174
    [Abstract] [Full Text] [Related]

  • 5. Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
    Dolan ME, Chae MY, Pegg AE, Mullen JH, Friedman HS, Moschel RC.
    Cancer Res; 1994 Oct 01; 54(19):5123-30. PubMed ID: 7923129
    [Abstract] [Full Text] [Related]

  • 6. Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.
    Crone TM, Kanugula S, Pegg AE.
    Carcinogenesis; 1995 Aug 01; 16(8):1687-92. PubMed ID: 7634390
    [Abstract] [Full Text] [Related]

  • 7. Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
    Hamdan MA, Guzman RC, Yang J, Beattie C, Mascharack P, Nandi S.
    Carcinogenesis; 1992 Oct 01; 13(10):1743-9. PubMed ID: 1423833
    [Abstract] [Full Text] [Related]

  • 8. Enhancement by O6-benzyl-N-acetylguanosine derivatives of chloroethylnitrosourea antitumor action in chloroethylnitrosourea-resistant human malignant melanocytes.
    Cussac C, Rapp M, Mounetou E, Madelmont JC, Maurizis JC, Godeneche D, Dupuy JM, Sauzieres J, Baudry JP, Veyre A.
    J Pharmacol Exp Ther; 1994 Dec 01; 271(3):1353-8. PubMed ID: 7996446
    [Abstract] [Full Text] [Related]

  • 9. Induction of rat liver O6-alkylguanine-DNA alkyltransferase following whole body X-irradiation.
    Schmerold I, Wiestler OD.
    Cancer Res; 1986 Jan 01; 46(1):245-9. PubMed ID: 3509992
    [Abstract] [Full Text] [Related]

  • 10. Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism.
    Kokkinakis DM, Moschel RC, Vuong TH, Reddy MV, Schold SC, Pegg AE.
    In Vivo; 1996 Jan 01; 10(3):297-306. PubMed ID: 8797031
    [Abstract] [Full Text] [Related]

  • 11. Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Pegg AE, Swenn K, Chae MY, Dolan ME, Moschel RC.
    Biochem Pharmacol; 1995 Oct 12; 50(8):1141-8. PubMed ID: 7488227
    [Abstract] [Full Text] [Related]

  • 12. Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
    Hansen RJ, Nagasubramanian R, Delaney SM, Cherian MM, Lin S, Kogan SC, Dolan ME.
    J Pharmacol Exp Ther; 2005 Dec 12; 315(3):1247-55. PubMed ID: 16126841
    [Abstract] [Full Text] [Related]

  • 13. Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
    Crone TM, Goodtzova K, Edara S, Pegg AE.
    Cancer Res; 1994 Dec 01; 54(23):6221-7. PubMed ID: 7954470
    [Abstract] [Full Text] [Related]

  • 14. [Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2'-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase].
    Dederer LIu, Sokolova IS, Bakhmedova AA, Miniker TD, Mel'nik SIa, Gorbacheva LB.
    Biokhimiia; 1995 Sep 01; 60(9):1521-9. PubMed ID: 8562657
    [Abstract] [Full Text] [Related]

  • 15. 2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase.
    Nelson ME, Loktionova NA, Pegg AE, Moschel RC.
    J Med Chem; 2004 Jul 15; 47(15):3887-91. PubMed ID: 15239666
    [Abstract] [Full Text] [Related]

  • 16. Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
    Roy SK, Gupta E, Dolan ME.
    Drug Metab Dispos; 1995 Dec 15; 23(12):1394-9. PubMed ID: 8689950
    [Abstract] [Full Text] [Related]

  • 17. [Inactivation of O6-alkylguanine-DNA alkyltransferase in the liver of rats during administration of methylated DNA].
    Likhachev AIa, Anisimov VN, Zhukovskaia NV, Petrov AS.
    Vopr Onkol; 1988 Dec 15; 34(4):458-63. PubMed ID: 3376459
    [Abstract] [Full Text] [Related]

  • 18. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
    Dolan ME, Moschel RC, Pegg AE.
    Proc Natl Acad Sci U S A; 1990 Jul 15; 87(14):5368-72. PubMed ID: 2164681
    [Abstract] [Full Text] [Related]

  • 19. Molecular characterization of mutations in the hprt gene of normal human skin keratinocytes treated with N-ethyl-N-nitrosourea: influence of O6-alkylguanine alkyltransferase.
    Tong HH, Park JH, Brady T, Weghorst CM, D'Ambrosio SM.
    Environ Mol Mutagen; 1997 Jul 15; 29(2):168-79. PubMed ID: 9118969
    [Abstract] [Full Text] [Related]

  • 20. O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
    Dolan ME, Roy SK, Garbiras BJ, Helft P, Paras P, Chae MY, Moschel RC, Pegg AE.
    Biochem Pharmacol; 1998 May 15; 55(10):1701-9. PubMed ID: 9634007
    [Abstract] [Full Text] [Related]

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