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230 related items for PubMed ID: 8940079

  • 1. The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.
    Ho L, Fukuchi Ki, Younkin SG.
    J Biol Chem; 1996 Nov 29; 271(48):30929-34. PubMed ID: 8940079
    [Abstract] [Full Text] [Related]

  • 2. Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer's disease.
    Boix CP, Lopez-Font I, Cuchillo-Ibañez I, Sáez-Valero J.
    Alzheimers Res Ther; 2020 Aug 12; 12(1):96. PubMed ID: 32787955
    [Abstract] [Full Text] [Related]

  • 3. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999 Aug 12; 249(6):266-70. PubMed ID: 10653281
    [Abstract] [Full Text] [Related]

  • 4. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
    Lahiri DK, Farlow MR, Sambamurti K.
    Brain Res Mol Brain Res; 1998 Nov 20; 62(2):131-40. PubMed ID: 9813282
    [Abstract] [Full Text] [Related]

  • 5. The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.
    Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL, Small DH.
    Eur J Biochem; 1999 Dec 20; 266(2):509-16. PubMed ID: 10561592
    [Abstract] [Full Text] [Related]

  • 6. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 20; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 7. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.
    Sambamurti K, Greig NH, Lahiri DK.
    Neuromolecular Med; 2002 Jun 20; 1(1):1-31. PubMed ID: 12025813
    [Abstract] [Full Text] [Related]

  • 8. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
    Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE.
    J Biol Chem; 2000 Nov 24; 275(47):36794-802. PubMed ID: 10962005
    [Abstract] [Full Text] [Related]

  • 9. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.
    Moir RD, Tanzi RE.
    Curr Alzheimer Res; 2005 Apr 24; 2(2):269-73. PubMed ID: 15974929
    [Abstract] [Full Text] [Related]

  • 10. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
    Siegel G, Gerber H, Koch P, Bruestle O, Fraering PC, Rajendran L.
    Cell Rep; 2017 Jun 06; 19(10):1967-1976. PubMed ID: 28591569
    [Abstract] [Full Text] [Related]

  • 11. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
    Hook VY, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T.
    J Neurochem; 2002 Apr 06; 81(2):237-56. PubMed ID: 12064471
    [Abstract] [Full Text] [Related]

  • 12. Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein.
    Sambamurti K, Sevlever D, Koothan T, Refolo LM, Pinnix I, Gandhi S, Onstead L, Younkin L, Prada CM, Yager D, Ohyagi Y, Eckman CB, Rosenberry TL, Younkin SG.
    J Biol Chem; 1999 Sep 17; 274(38):26810-4. PubMed ID: 10480887
    [Abstract] [Full Text] [Related]

  • 13. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
    Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL.
    J Biol Chem; 1998 Feb 27; 273(9):5013-9. PubMed ID: 9478949
    [Abstract] [Full Text] [Related]

  • 14. Commentary: Abeta N- Terminal Isoforms: Critical contributors in the course of AD pathophysiology.
    Tekirian TL.
    J Alzheimers Dis; 2001 Apr 27; 3(2):241-248. PubMed ID: 12214065
    [Abstract] [Full Text] [Related]

  • 15. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S, Sunyach C, Checler F.
    J Neurochem; 2006 May 27; 97(3):807-17. PubMed ID: 16524370
    [Abstract] [Full Text] [Related]

  • 16. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
    Buggia-Prevot V, Sevalle J, Rossner S, Checler F.
    J Biol Chem; 2008 Apr 11; 283(15):10037-47. PubMed ID: 18263584
    [Abstract] [Full Text] [Related]

  • 17. A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
    Skovronsky DM, Pijak DS, Doms RW, Lee VM.
    Biochemistry; 2000 Feb 01; 39(4):810-7. PubMed ID: 10651647
    [Abstract] [Full Text] [Related]

  • 18. CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
    Dobrowolska JA, Michener MS, Wu G, Patterson BW, Chott R, Ovod V, Pyatkivskyy Y, Wildsmith KR, Kasten T, Mathers P, Dancho M, Lennox C, Smith BE, Gilberto D, McLoughlin D, Holder DJ, Stamford AW, Yarasheski KE, Kennedy ME, Savage MJ, Bateman RJ.
    J Neurosci; 2014 Jun 11; 34(24):8336-46. PubMed ID: 24920637
    [Abstract] [Full Text] [Related]

  • 19. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.
    Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K.
    Neurodegener Dis; 2009 Jun 11; 6(5-6):258-62. PubMed ID: 19955704
    [Abstract] [Full Text] [Related]

  • 20. ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε.
    Cisse M, Braun U, Leitges M, Fisher A, Pages G, Checler F, Vincent B.
    Mol Cell Neurosci; 2011 Jul 11; 47(3):223-32. PubMed ID: 21570469
    [Abstract] [Full Text] [Related]


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