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227 related items for PubMed ID: 8950972

  • 1. p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus.
    Byrne JL, Paterson HF, Marshall CJ.
    Oncogene; 1996 Nov 21; 13(10):2055-65. PubMed ID: 8950972
    [Abstract] [Full Text] [Related]

  • 2. Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
    Xu XX, Yi T, Tang B, Lambeth JD.
    Oncogene; 1998 Mar 26; 16(12):1561-9. PubMed ID: 9569023
    [Abstract] [Full Text] [Related]

  • 3. MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.
    Rozakis-Adcock M, van der Geer P, Mbamalu G, Pawson T.
    Oncogene; 1995 Oct 05; 11(7):1417-26. PubMed ID: 7478566
    [Abstract] [Full Text] [Related]

  • 4. Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus.
    Gupta RW, Mayer BJ.
    Oncogene; 1998 Oct 29; 17(17):2155-65. PubMed ID: 9811447
    [Abstract] [Full Text] [Related]

  • 5. Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.
    Janes PW, Daly RJ, deFazio A, Sutherland RL.
    Oncogene; 1994 Dec 29; 9(12):3601-8. PubMed ID: 7970720
    [Abstract] [Full Text] [Related]

  • 6. Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.
    Doza YN, Hall-Jackson CA, Cohen P.
    Oncogene; 1998 Jul 09; 17(1):19-24. PubMed ID: 9671310
    [Abstract] [Full Text] [Related]

  • 7. Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation.
    Corbalan-Garcia S, Degenhardt KR, Bar-Sagi D.
    Oncogene; 1996 Mar 07; 12(5):1063-8. PubMed ID: 8649797
    [Abstract] [Full Text] [Related]

  • 8. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
    Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D.
    Nature; 1993 May 06; 363(6424):88-92. PubMed ID: 8386805
    [Abstract] [Full Text] [Related]

  • 9. A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
    Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ.
    Nature; 1996 Feb 08; 379(6565):560-4. PubMed ID: 8596638
    [Abstract] [Full Text] [Related]

  • 10. Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc.
    Kranenburg O, Verlaan I, Hordijk PL, Moolenaar WH.
    EMBO J; 1997 Jun 02; 16(11):3097-105. PubMed ID: 9214627
    [Abstract] [Full Text] [Related]

  • 11. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
    Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA.
    Nature; 1993 May 06; 363(6424):45-51. PubMed ID: 8479536
    [Abstract] [Full Text] [Related]

  • 12. Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.
    Buday L, Warne PH, Downward J.
    Oncogene; 1995 Oct 05; 11(7):1327-31. PubMed ID: 7478553
    [Abstract] [Full Text] [Related]

  • 13. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.
    Cussac D, Vidal M, Leprince C, Liu WQ, Cornille F, Tiraboschi G, Roques BP, Garbay C.
    FASEB J; 1999 Jan 05; 13(1):31-8. PubMed ID: 9872927
    [Abstract] [Full Text] [Related]

  • 14. Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.
    de Vries-Smits AM, Pronk GJ, Medema JP, Burgering BM, Bos JL.
    Oncogene; 1995 Mar 02; 10(5):919-25. PubMed ID: 7898933
    [Abstract] [Full Text] [Related]

  • 15. The Grb2 binding domain of mSos1 is not required for downstream signal transduction.
    Wang W, Fisher EM, Jia Q, Dunn JM, Porfiri E, Downward J, Egan SE.
    Nat Genet; 1995 Jul 02; 10(3):294-300. PubMed ID: 7670467
    [Abstract] [Full Text] [Related]

  • 16. Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.
    Langlois WJ, Sasaoka T, Saltiel AR, Olefsky JM.
    J Biol Chem; 1995 Oct 27; 270(43):25320-3. PubMed ID: 7592690
    [Abstract] [Full Text] [Related]

  • 17. Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
    Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A.
    J Mol Biol; 2002 Feb 01; 315(5):1167-77. PubMed ID: 11827484
    [Abstract] [Full Text] [Related]

  • 18. Activation of p70/p85 S6 kinase by a pathway independent of p21ras.
    Ming XF, Burgering BM, Wennström S, Claesson-Welsh L, Heldin CH, Bos JL, Kozma SC, Thomas G.
    Nature; 1994 Sep 29; 371(6496):426-9. PubMed ID: 8090223
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain.
    Jefferson AB, Klippel A, Williams LT.
    Oncogene; 1998 May 07; 16(18):2303-10. PubMed ID: 9620547
    [Abstract] [Full Text] [Related]

  • 20. Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.
    Charest A, Wagner J, Kwan M, Tremblay ML.
    Oncogene; 1997 Apr 10; 14(14):1643-51. PubMed ID: 9135065
    [Abstract] [Full Text] [Related]

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