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Journal Abstract Search

202 related items for PubMed ID: 8953047

  • 1. A mechanism of drug action revealed by structural studies of enoyl reductase.
    Baldock C, Rafferty JB, Sedelnikova SE, Baker PJ, Stuitje AR, Slabas AR, Hawkes TR, Rice DW.
    Science; 1996 Dec 20; 274(5295):2107-10. PubMed ID: 8953047
    [Abstract] [Full Text] [Related]

  • 2. The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA.
    Bergler H, Fuchsbichler S, Högenauer G, Turnowsky F.
    Eur J Biochem; 1996 Dec 15; 242(3):689-94. PubMed ID: 9022698
    [Abstract] [Full Text] [Related]

  • 3. A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.
    Levy CW, Baldock C, Wallace AJ, Sedelnikova S, Viner RC, Clough JM, Stuitje AR, Slabas AR, Rice DW, Rafferty JB.
    J Mol Biol; 2001 May 25; 309(1):171-80. PubMed ID: 11491286
    [Abstract] [Full Text] [Related]

  • 4. Structural basis and mechanism of enoyl reductase inhibition by triclosan.
    Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C.
    J Mol Biol; 1999 Jul 23; 290(4):859-65. PubMed ID: 10398587
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of action of diazaborines.
    Baldock C, de Boer GJ, Rafferty JB, Stuitje AR, Rice DW.
    Biochem Pharmacol; 1998 May 15; 55(10):1541-9. PubMed ID: 9633989
    [Abstract] [Full Text] [Related]

  • 6. Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
    Rozwarski DA, Grant GA, Barton DH, Jacobs WR, Sacchettini JC.
    Science; 1998 Jan 02; 279(5347):98-102. PubMed ID: 9417034
    [Abstract] [Full Text] [Related]

  • 7. Crystallographic analysis of triclosan bound to enoyl reductase.
    Roujeinikova A, Levy CW, Rowsell S, Sedelnikova S, Baker PJ, Minshull CA, Mistry A, Colls JG, Camble R, Stuitje AR, Slabas AR, Rafferty JB, Pauptit RA, Viner R, Rice DW.
    J Mol Biol; 1999 Nov 26; 294(2):527-35. PubMed ID: 10610777
    [Abstract] [Full Text] [Related]

  • 8. Inhibitor binding studies on enoyl reductase reveal conformational changes related to substrate recognition.
    Roujeinikova A, Sedelnikova S, de Boer GJ, Stuitje AR, Slabas AR, Rafferty JB, Rice DW.
    J Biol Chem; 1999 Oct 22; 274(43):30811-7. PubMed ID: 10521472
    [Abstract] [Full Text] [Related]

  • 9. The X-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 A resolution.
    Baldock C, Rafferty JB, Stuitje AR, Slabas AR, Rice DW.
    J Mol Biol; 1998 Dec 18; 284(5):1529-46. PubMed ID: 9878369
    [Abstract] [Full Text] [Related]

  • 10. Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine.
    de Boer GJ, Pielage GJ, Nijkamp HJ, Slabas AR, Rafferty JB, Baldock C, Rice DW, Stuitje AR.
    Mol Microbiol; 1999 Jan 18; 31(2):443-50. PubMed ID: 10027962
    [Abstract] [Full Text] [Related]

  • 11. Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan.
    Ward WH, Holdgate GA, Rowsell S, McLean EG, Pauptit RA, Clayton E, Nichols WW, Colls JG, Minshull CA, Jude DA, Mistry A, Timms D, Camble R, Hales NJ, Britton CJ, Taylor IW.
    Biochemistry; 1999 Sep 21; 38(38):12514-25. PubMed ID: 10493822
    [Abstract] [Full Text] [Related]

  • 12. Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase.
    Rafferty JB, Simon JW, Baldock C, Artymiuk PJ, Baker PJ, Stuitje AR, Slabas AR, Rice DW.
    Structure; 1995 Sep 15; 3(9):927-38. PubMed ID: 8535786
    [Abstract] [Full Text] [Related]

  • 13. Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).
    Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF.
    J Med Chem; 2002 Jul 18; 45(15):3246-56. PubMed ID: 12109908
    [Abstract] [Full Text] [Related]

  • 14. The use of a hybrid genetic system to study the functional relationship between prokaryotic and plant multi-enzyme fatty acid synthetase complexes.
    Kater MM, Koningstein GM, Nijkamp HJ, Stuitje AR.
    Plant Mol Biol; 1994 Aug 18; 25(5):771-90. PubMed ID: 8075395
    [Abstract] [Full Text] [Related]

  • 15. 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
    Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF.
    Bioorg Med Chem Lett; 2001 Aug 20; 11(16):2061-5. PubMed ID: 11514139
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.
    Seefeld MA, Miller WH, Newlander KA, Burgess WJ, Payne DJ, Rittenhouse SF, Moore TD, DeWolf WE, Keller PM, Qiu X, Janson CA, Vaidya K, Fosberry AP, Smyth MG, Jaworski DD, Slater-Radosti C, Huffman WF.
    Bioorg Med Chem Lett; 2001 Sep 03; 11(17):2241-4. PubMed ID: 11527706
    [Abstract] [Full Text] [Related]

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  • 18. Exploring the interaction energies for the binding of hydroxydiphenyl ethers to enoyl-acyl carrier protein reductases.
    Muralidharan J, Suguna K, Surolia A, Surolia N.
    J Biomol Struct Dyn; 2003 Feb 03; 20(4):589-94. PubMed ID: 12529157
    [Abstract] [Full Text] [Related]

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  • 20. Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
    Rafi S, Novichenok P, Kolappan S, Stratton CF, Rawat R, Kisker C, Simmerling C, Tonge PJ.
    J Biol Chem; 2006 Dec 22; 281(51):39285-39293. PubMed ID: 17012233
    [Abstract] [Full Text] [Related]

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