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Journal Abstract Search

285 related items for PubMed ID: 8973202

  • 1. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis.
    Ibdah M, Bar-Ilan A, Livnah O, Schloss JV, Barak Z, Chipman DM.
    Biochemistry; 1996 Dec 17; 35(50):16282-91. PubMed ID: 8973202
    [Abstract] [Full Text] [Related]

  • 2. Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.
    Steinmetz A, Vyazmensky M, Meyer D, Barak ZE, Golbik R, Chipman DM, Tittmann K.
    Biochemistry; 2010 Jun 29; 49(25):5188-99. PubMed ID: 20504042
    [Abstract] [Full Text] [Related]

  • 3. Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.
    Belenky I, Steinmetz A, Vyazmensky M, Barak Z, Tittmann K, Chipman DM.
    FEBS J; 2012 Jun 29; 279(11):1967-79. PubMed ID: 22443469
    [Abstract] [Full Text] [Related]

  • 4. Homology modeling of the structure of tobacco acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis.
    Le DT, Yoon MY, Kim YT, Choi JD.
    Biochem Biophys Res Commun; 2004 May 07; 317(3):930-8. PubMed ID: 15081429
    [Abstract] [Full Text] [Related]

  • 5. Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.
    Vyazmensky M, Steinmetz A, Meyer D, Golbik R, Barak Z, Tittmann K, Chipman DM.
    Biochemistry; 2011 Apr 19; 50(15):3250-60. PubMed ID: 21370850
    [Abstract] [Full Text] [Related]

  • 6. Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis.
    Mendel S, Elkayam T, Sella C, Vinogradov V, Vyazmensky M, Chipman DM, Barak Z.
    J Mol Biol; 2001 Mar 16; 307(1):465-77. PubMed ID: 11243831
    [Abstract] [Full Text] [Related]

  • 7. Structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from Escherichia coli.
    Kaplun A, Vyazmensky M, Zherdev Y, Belenky I, Slutzker A, Mendel S, Barak Z, Chipman DM, Shaanan B.
    J Mol Biol; 2006 Mar 31; 357(3):951-63. PubMed ID: 16458324
    [Abstract] [Full Text] [Related]

  • 8. 6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding.
    Bürgisser DM, Thöny B, Redweik U, Hess D, Heizmann CW, Huber R, Nar H.
    J Mol Biol; 1995 Oct 20; 253(2):358-69. PubMed ID: 7563095
    [Abstract] [Full Text] [Related]

  • 9. Structural and functional evaluation of three well-conserved serine residues in tobacco acetohydroxyacid synthase.
    Yoon MY, Gedi V, Kim J, Park Y, Kim DE, Park EH, Choi JD.
    Biochimie; 2010 Jan 20; 92(1):65-70. PubMed ID: 19825392
    [Abstract] [Full Text] [Related]

  • 10. Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors.
    Pang SS, Duggleby RG, Guddat LW.
    J Mol Biol; 2002 Mar 22; 317(2):249-62. PubMed ID: 11902841
    [Abstract] [Full Text] [Related]

  • 11. Roles of three well-conserved arginine residues in mediating the catalytic activity of tobacco acetohydroxy acid synthase.
    Le DT, Yoon MY, Kim YT, Choi JD.
    J Biochem; 2005 Jul 22; 138(1):35-40. PubMed ID: 16046446
    [Abstract] [Full Text] [Related]

  • 12. The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR.
    Tittmann K, Vyazmensky M, Hübner G, Barak Z, Chipman DM.
    Proc Natl Acad Sci U S A; 2005 Jan 18; 102(3):553-8. PubMed ID: 15640355
    [Abstract] [Full Text] [Related]

  • 13. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.
    Bar-Ilan A, Balan V, Tittmann K, Golbik R, Vyazmensky M, Hübner G, Barak Z, Chipman DM.
    Biochemistry; 2001 Oct 02; 40(39):11946-54. PubMed ID: 11570896
    [Abstract] [Full Text] [Related]

  • 14. Mutagenesis of Escherichia coli acetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms.
    Hill CM, Duggleby RG.
    Biochem J; 1998 Nov 01; 335 ( Pt 3)(Pt 3):653-61. PubMed ID: 9794808
    [Abstract] [Full Text] [Related]

  • 15. Amino acid residues conferring herbicide resistance in tobacco acetohydroxy acid synthase.
    Jung SM, Le DT, Yoon SS, Yoon MY, Kim YT, Choi JD.
    Biochem J; 2004 Oct 01; 383(Pt 1):53-61. PubMed ID: 15214847
    [Abstract] [Full Text] [Related]

  • 16. Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
    Tittmann K, Schröder K, Golbik R, McCourt J, Kaplun A, Duggleby RG, Barak Z, Chipman DM, Hübner G.
    Biochemistry; 2004 Jul 13; 43(27):8652-61. PubMed ID: 15236573
    [Abstract] [Full Text] [Related]

  • 17. Channeling behavior and activity models for Escherichia coli K-12 acetohydroxy acid synthases at physiological substrate levels.
    Herring PA, McKnight BL, Jackson JH.
    Biochem Biophys Res Commun; 1995 Feb 06; 207(1):48-54. PubMed ID: 7857304
    [Abstract] [Full Text] [Related]

  • 18. Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.
    Baig IA, Gedi V, Lee SC, Koh SH, Yoon MY.
    Enzyme Microb Technol; 2013 Sep 10; 53(4):243-9. PubMed ID: 23931689
    [Abstract] [Full Text] [Related]

  • 19. The structure of serine hydroxymethyltransferase as modeled by homology and validated by site-directed mutagenesis.
    Pascarella S, Angelaccio S, Contestabile R, Delle Fratte S, Di Salvo M, Bossa F.
    Protein Sci; 1998 Sep 10; 7(9):1976-82. PubMed ID: 9761478
    [Abstract] [Full Text] [Related]

  • 20. Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases.
    Chipman D, Barak Z, Schloss JV.
    Biochim Biophys Acta; 1998 Jun 29; 1385(2):401-19. PubMed ID: 9655946
    [Abstract] [Full Text] [Related]

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