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2. Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence. Shen KF, Crain SM. Brain Res; 1994 Feb 14; 636(2):286-97. PubMed ID: 8012813 [Abstract] [Full Text] [Related]
3. Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1 ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic morphine-treated cells. Crain SM, Shen KF. Brain Res; 1996 Nov 25; 741(1-2):275-83. PubMed ID: 9001733 [Abstract] [Full Text] [Related]
4. After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioid agonists and antagonists as occurs after acute elevation of GM1 ganglioside. Crain SM, Shen KF. Brain Res; 1992 Mar 13; 575(1):13-24. PubMed ID: 1324084 [Abstract] [Full Text] [Related]
6. Biphalin, an enkephalin analog with unexpectedly high antinociceptive potency and low dependence liability in vivo, selectively antagonizes excitatory opioid receptor functions of sensory neurons in culture. Shen KF, Crain SM. Brain Res; 1995 Dec 01; 701(1-2):158-66. PubMed ID: 8925279 [Abstract] [Full Text] [Related]
7. Chronic selective activation of excitatory opioid receptor functions in sensory neurons results in opioid 'dependence' without tolerance. Shen KF, Crain SM. Brain Res; 1992 Nov 27; 597(1):74-83. PubMed ID: 1335822 [Abstract] [Full Text] [Related]
9. Specific N- or C-terminus modified dynorphin and beta-endorphin peptides can selectively block excitatory opioid receptor functions in sensory neurons and unmask potent inhibitory effects of opioid agonists. Shen KF, Crain SM. Brain Res; 1995 Feb 27; 673(1):30-8. PubMed ID: 7757476 [Abstract] [Full Text] [Related]
10. Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. Shen KF, Crain SM. Brain Res; 1997 May 23; 757(2):176-90. PubMed ID: 9200746 [Abstract] [Full Text] [Related]
17. Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons. Cai Q, Qiu CY, Qiu F, Liu TT, Qu ZW, Liu YM, Hu WP. Brain Res; 2014 Mar 20; 1554():12-20. PubMed ID: 24491633 [Abstract] [Full Text] [Related]
18. Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice. Crain SM, Shen KF. Brain Res; 2007 Sep 05; 1167():31-41. PubMed ID: 17692296 [Abstract] [Full Text] [Related]