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Journal Abstract Search

193 related items for PubMed ID: 9016326

  • 21. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
    Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME.
    J Med Chem; 2002 Jan 31; 45(3):654-62. PubMed ID: 11806716
    [Abstract] [Full Text] [Related]

  • 22. Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
    Matecka D, Rothman RB, Radesca L, de Costa BR, Dersch CM, Partilla JS, Pert A, Glowa JR, Wojnicki FH, Rice KC.
    J Med Chem; 1996 Nov 22; 39(24):4704-16. PubMed ID: 8941383
    [Abstract] [Full Text] [Related]

  • 23. Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
    Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML.
    J Med Chem; 2005 Mar 10; 48(5):1336-43. PubMed ID: 15743177
    [Abstract] [Full Text] [Related]

  • 24. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label.
    Dutta AK, Fei XS, Vaughan RA, Gaffaney JD, Wang N, Lever JR, Reith ME.
    Life Sci; 2001 Mar 09; 68(16):1839-49. PubMed ID: 11292062
    [Abstract] [Full Text] [Related]

  • 25. CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.
    Newman AH, Izenwasser S, Robarge MJ, Kline RH.
    J Med Chem; 1999 Sep 09; 42(18):3502-9. PubMed ID: 10479283
    [Abstract] [Full Text] [Related]

  • 26. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
    Chen N, Zhen J, Reith ME.
    J Neurochem; 2004 May 09; 89(4):853-64. PubMed ID: 15140185
    [Abstract] [Full Text] [Related]

  • 27. Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?
    Xu C, Reith ME.
    J Pharmacol Exp Ther; 1996 Sep 09; 278(3):1340-8. PubMed ID: 8819521
    [Abstract] [Full Text] [Related]

  • 28. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
    Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK.
    J Pharmacol Exp Ther; 2005 Aug 09; 314(2):575-83. PubMed ID: 15879005
    [Abstract] [Full Text] [Related]

  • 29. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.
    Goodman MM, Chen P, Plisson C, Martarello L, Galt J, Votaw JR, Kilts CD, Malveaux G, Camp VM, Shi B, Ely TD, Howell L, McConathy J, Nemeroff CB.
    J Med Chem; 2003 Mar 13; 46(6):925-35. PubMed ID: 12620070
    [Abstract] [Full Text] [Related]

  • 30. Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives.
    Xu L, Kelkar SV, Lomenzo SA, Izenwasser S, Katz JL, Kline RH, Trudell ML.
    J Med Chem; 1997 Mar 14; 40(6):858-63. PubMed ID: 9083474
    [Abstract] [Full Text] [Related]

  • 31. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
    Rothman RB, Carroll FI, Morales M, Rowley DL, Rice KC, Dersch CM, Donovan DM.
    Synapse; 2002 May 14; 44(2):94-105. PubMed ID: 11891881
    [Abstract] [Full Text] [Related]

  • 32. Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.
    Lewis DB, Matecka D, Zhang Y, Hsin LW, Dersch CM, Stafford D, Glowa JR, Rothman RB, Rice KC.
    J Med Chem; 1999 Dec 02; 42(24):5029-42. PubMed ID: 10585212
    [Abstract] [Full Text] [Related]

  • 33. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
    Zhang S, Zhen J, Reith ME, Dutta AK.
    J Med Chem; 2005 Jul 28; 48(15):4962-71. PubMed ID: 16033275
    [Abstract] [Full Text] [Related]

  • 34. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions.
    Itokawa M, Lin Z, Cai NS, Wu C, Kitayama S, Wang JB, Uhl GR.
    Mol Pharmacol; 2000 Jun 28; 57(6):1093-103. PubMed ID: 10825379
    [Abstract] [Full Text] [Related]

  • 35. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.
    Plisson C, McConathy J, Martarello L, Malveaux EJ, Camp VM, Williams L, Votaw JR, Goodman MM.
    J Med Chem; 2004 Feb 26; 47(5):1122-35. PubMed ID: 14971892
    [Abstract] [Full Text] [Related]

  • 36. Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.
    Kotian P, Mascarella SW, Abraham P, Lewin AH, Boja JW, Kuhar MJ, Carroll FI.
    J Med Chem; 1996 Jul 05; 39(14):2753-63. PubMed ID: 8709106
    [Abstract] [Full Text] [Related]

  • 37. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.
    Kolhatkar R, Cook CD, Ghorai SK, Deschamps J, Beardsley PM, Reith ME, Dutta AK.
    J Med Chem; 2004 Oct 07; 47(21):5101-13. PubMed ID: 15456254
    [Abstract] [Full Text] [Related]

  • 38. Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity.
    Volz TJ, Kim M, Schenk JO.
    Synapse; 2004 Jun 15; 52(4):272-82. PubMed ID: 15103693
    [Abstract] [Full Text] [Related]

  • 39. 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
    Holmquist CR, Keverline-Frantz KI, Abraham P, Boja JW, Kuhar MJ, Carroll FI.
    J Med Chem; 1996 Oct 11; 39(21):4139-41. PubMed ID: 8863789
    [No Abstract] [Full Text] [Related]

  • 40. O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
    Madras BK, Reith ME, Meltzer PC, Dutta AK.
    Eur J Pharmacol; 1994 Apr 15; 267(2):167-73. PubMed ID: 8050478
    [Abstract] [Full Text] [Related]

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