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Journal Abstract Search

258 related items for PubMed ID: 9022750

  • 1. Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Bavetsias V, Jackman AL, Boyle FT, Marshall D, Pedley RB, Bisset GM.
    Anticancer Drug Des; 1996 Dec; 11(8):625-36. PubMed ID: 9022750
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  • 2. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
    J Med Chem; 1998 Dec 17; 41(26):5297-309. PubMed ID: 9857097
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  • 3. Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.
    Wolfe LA, Mullin RJ, Laethem R, Blumenkopf TA, Cory M, Miller JF, Keith BR, Humphreys J, Smith GK.
    Bioconjug Chem; 1999 Dec 17; 10(1):38-48. PubMed ID: 9893962
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  • 4. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR.
    Cancer Res; 1991 Oct 15; 51(20):5579-86. PubMed ID: 1913676
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  • 5. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1996 Jan 05; 39(1):73-85. PubMed ID: 8568829
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  • 7. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR, Varney MD, Webber SE, Lewis KK, Marzoni GP, Palmer CL, Kathardekar V, Welsh KM, Webber S, Matthews DA, Appelt K, Smith WW, Janson CA, Villafranca JE, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Moomaw EW, Bartlett CA, Morse CA.
    J Med Chem; 1996 Feb 16; 39(4):904-17. PubMed ID: 8632414
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  • 8. Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Marriott JH, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1997 May 09; 40(10):1495-510. PubMed ID: 9154971
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  • 10. Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Antoniw P, Bagshawe KD, Wilman DE.
    Anticancer Drug Des; 1991 Nov 09; 6(5):467-79. PubMed ID: 1764165
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  • 14. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
    Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ.
    J Med Chem; 1999 Mar 25; 42(6):951-6. PubMed ID: 10090777
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