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Journal Abstract Search

143 related items for PubMed ID: 9022805

  • 1. Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
    Piper JR, DeGraw JI, Colwell WT, Johnson CA, Smith RL, Waud WR, Sirotnak FM.
    J Med Chem; 1997 Jan 31; 40(3):377-84. PubMed ID: 9022805
    [Abstract] [Full Text] [Related]

  • 2. Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
    DeGraw JI, Colwell WT, Crase J, Smith RL, Piper JR, Waud WR, Sirotnak FM.
    J Med Chem; 1997 Jan 31; 40(3):370-6. PubMed ID: 9022804
    [Abstract] [Full Text] [Related]

  • 3. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
    Piper JR, Ramamurthy B, Johnson CA, Otter GM, Sirotnak FM.
    J Med Chem; 1996 Jan 19; 39(2):614-8. PubMed ID: 8558535
    [Abstract] [Full Text] [Related]

  • 4. Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
    Sirotnak FM, Schmid FA, Otter GM, Piper JR, Montgomery JA.
    Cancer Res; 1988 Oct 15; 48(20):5686-91. PubMed ID: 3167828
    [Abstract] [Full Text] [Related]

  • 5. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Jun 15; 29(6):1080-7. PubMed ID: 2423690
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 15; 34(4):1447-54. PubMed ID: 2016722
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
    DeGraw JI, Christie PH, Brown EG, Kelly LF, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1984 Mar 15; 27(3):376-80. PubMed ID: 6699882
    [Abstract] [Full Text] [Related]

  • 8. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Samuels LL, Moccio DM, Sirotnak FM.
    Cancer Res; 1985 Apr 15; 45(4):1488-95. PubMed ID: 3978616
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN.
    J Med Chem; 1998 Dec 17; 41(26):5310-9. PubMed ID: 9857098
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
    Piper JR, Johnson CA, Otter GM, Sirotnak FM.
    J Med Chem; 1992 Aug 07; 35(16):3002-6. PubMed ID: 1501226
    [Abstract] [Full Text] [Related]

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  • 12. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
    Kuehl M, Brixner DI, Broom AD, Avery TL, Blakley RL.
    Cancer Res; 1988 Mar 15; 48(6):1481-8. PubMed ID: 2449950
    [Abstract] [Full Text] [Related]

  • 13. Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
    Ueda T, Dutschman GE, Nair MG, Degraw JI, Sirotnak FM, Cheng YC.
    Mol Pharmacol; 1986 Aug 15; 30(2):149-53. PubMed ID: 2426568
    [Abstract] [Full Text] [Related]

  • 14. Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.
    McGuire JJ, Haile WH.
    Biochem Pharmacol; 2009 Apr 01; 77(7):1161-72. PubMed ID: 19174154
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
    DeGraw JI, Colwell WT, Piper JR, Sirotnak FM.
    J Med Chem; 1993 Jul 23; 36(15):2228-31. PubMed ID: 8340923
    [Abstract] [Full Text] [Related]

  • 16. New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
    Abraham A, McGuire JJ, Galivan J, Vishnuvajjala BR, Nair MG.
    Adv Exp Med Biol; 1993 Jul 23; 338():421-4. PubMed ID: 8304149
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Nov 24; 31(11):2164-9. PubMed ID: 3184124
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
    DeGraw JI, Christie PH, Colwell WT, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):320-4. PubMed ID: 1732549
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.
    Su TL, Huang JT, Burchenal JH, Watanabe KA, Fox JJ.
    J Med Chem; 1986 May 24; 29(5):709-15. PubMed ID: 3754585
    [Abstract] [Full Text] [Related]

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