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Journal Abstract Search

121 related items for PubMed ID: 9028337

  • 1. Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice.
    Smith AG, Clothier B, Francis JE, Gibbs AH, De Matteis F, Hider RC.
    Blood; 1997 Feb 01; 89(3):1045-51. PubMed ID: 9028337
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  • 2. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat.
    Choudhury R, Singh S.
    Drug Metab Dispos; 1995 Mar 01; 23(3):314-20. PubMed ID: 7628295
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  • 3. Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
    Frater Y, Brady A, Lock EA, De Matteis F.
    Arch Toxicol; 1993 Mar 01; 67(3):179-85. PubMed ID: 8494497
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  • 4. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.
    Porter JB, Abeysinghe RD, Hoyes KP, Barra C, Huehns ER, Brooks PN, Blackwell MP, Araneta M, Brittenham G, Singh S.
    Br J Haematol; 1993 Sep 01; 85(1):159-68. PubMed ID: 8251385
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  • 5. Metabolism and pharmacokinetics of 1-(2'-trimethylacetoxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP117) in the rat.
    Choudhury R, Epemolu RO, Rai BL, Hider RC, Singh S.
    Drug Metab Dispos; 1997 Mar 01; 25(3):332-9. PubMed ID: 9172951
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  • 7. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones.
    Singh S, Epemolu RO, Dobbin PS, Tilbrook GS, Ellis BL, Damani LA, Hider RC.
    Drug Metab Dispos; 1992 Mar 01; 20(2):256-61. PubMed ID: 1352218
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  • 9. Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice.
    Porter JB, Morgan J, Hoyes KP, Burke LC, Huehns ER, Hider RC.
    Blood; 1990 Dec 01; 76(11):2389-96. PubMed ID: 2257308
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  • 10. Comparison of the subacute toxicity and efficacy of 3-hydroxypyridin-4-one iron chelators in overloaded and nonoverloaded mice.
    Porter JB, Hoyes KP, Abeysinghe RD, Brooks PN, Huehns ER, Hider RC.
    Blood; 1991 Nov 15; 78(10):2727-34. PubMed ID: 1824264
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  • 11. Characterization of two isomeric beta-d-glucosiduronic acids derived from 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rat liver homogenate incubates.
    Liu DY, Liu ZD, Piyamongkol S, Lu SL, Hider RC.
    J Pharm Pharmacol; 2002 Jul 15; 54(7):951-7. PubMed ID: 12162714
    [Abstract] [Full Text] [Related]

  • 12. Lessons from preclinical and clinical studies with 1,2-diethyl-3-hydroxypyridin-4-one, CP94 and related compounds.
    Porter JB, Singh S, Hoyes KP, Epemolu O, Abeysinghe RD, Hider RC.
    Adv Exp Med Biol; 1994 Jul 15; 356():361-70. PubMed ID: 7887242
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  • 13. Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.
    Jacobs JM, Sinclair PR, Sinclair JF, Gorman N, Walton HS, Wood SG, Nichols C.
    Toxicology; 1998 Feb 06; 125(2-3):95-105. PubMed ID: 9570325
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  • 14. In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
    Hoyes KP, Jones HM, Abeysinghe RD, Hider RC, Porter JB.
    Exp Hematol; 1993 Jan 06; 21(1):86-92. PubMed ID: 8417963
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  • 15. Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools.
    Hoyes KP, Porter JB.
    Br J Haematol; 1993 Oct 06; 85(2):393-400. PubMed ID: 8280612
    [Abstract] [Full Text] [Related]

  • 16. The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study.
    Chang SC, MacRobert AJ, Porter JB, Bown SG.
    J Photochem Photobiol B; 1997 Apr 06; 38(2-3):114-22. PubMed ID: 9203372
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  • 17. Biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in the rat.
    Lu SL, Gosriwatana I, Liu DY, Liu ZD, Mallet AI, Hider RC.
    Drug Metab Dispos; 2000 Aug 06; 28(8):873-9. PubMed ID: 10901694
    [Abstract] [Full Text] [Related]

  • 18. Synthesis, physicochemical properties and biological evaluation of aromatic ester prodrugs of 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102): orally active iron chelators with clinical potential.
    Liu ZD, Liu DY, Lu SL, Hider RC.
    J Pharm Pharmacol; 1999 May 06; 51(5):555-64. PubMed ID: 10411215
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