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Journal Abstract Search

414 related items for PubMed ID: 9033393

  • 1. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ, Tardif C, Kutcher LW, Mehdi S, Schatzman GL, Neises B, Peet NP.
    Biochemistry; 1997 Feb 04; 36(5):1034-40. PubMed ID: 9033393
    [Abstract] [Full Text] [Related]

  • 2. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

  • 3. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
    [Abstract] [Full Text] [Related]

  • 4. The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.
    Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP.
    Protein Sci; 1997 Jul 13; 6(7):1412-7. PubMed ID: 9232642
    [Abstract] [Full Text] [Related]

  • 5. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 6. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
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  • 8. Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases.
    Bajusz S, Fauszt I, Németh K, Barabás E, Juhász A, Patthy M, Bauer PI.
    Biopolymers; 1999 May 24; 51(1):109-18. PubMed ID: 10380358
    [Abstract] [Full Text] [Related]

  • 9. Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.
    Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.
    Biochemistry; 1997 Nov 04; 36(44):13494-502. PubMed ID: 9354617
    [Abstract] [Full Text] [Related]

  • 10. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.
    J Mol Biol; 2009 Aug 21; 391(3):552-64. PubMed ID: 19520086
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  • 12. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW.
    Protein Sci; 2000 Jan 21; 9(1):29-36. PubMed ID: 10739244
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of bovine beta-trypsin, human alpha-thrombin and porcine pancreatic beta-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: thermodynamic and molecular modeling study.
    Menegatti E, Ferroni R, Nastruzzi C, Bortolotti F, Scalia S, Amiconi G, Bolognesi M, Coletta M, Onesti S, Fruttero R.
    Farmaco; 1991 Nov 21; 46(11):1297-310. PubMed ID: 1811616
    [Abstract] [Full Text] [Related]

  • 14. Thermodynamic criterion for the conformation of P1 residues of substrates and of inhibitors in complexes with serine proteinases.
    Qasim MA, Lu SM, Ding J, Bateman KS, James MN, Anderson S, Song J, Markley JL, Ganz PJ, Saunders CW, Laskowski M.
    Biochemistry; 1999 Jun 01; 38(22):7142-50. PubMed ID: 10353824
    [Abstract] [Full Text] [Related]

  • 15. Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
    Dullweber F, Stubbs MT, Musil D, Stürzebecher J, Klebe G.
    J Mol Biol; 2001 Oct 26; 313(3):593-614. PubMed ID: 11676542
    [Abstract] [Full Text] [Related]

  • 16. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.
    Katz BA, Luong C.
    J Mol Biol; 1999 Sep 24; 292(3):669-84. PubMed ID: 10497030
    [Abstract] [Full Text] [Related]

  • 17. Design of noncovalent trypsin inhibitor based on the X-ray crystal structure of the complex.
    Nakamura M, Tomoo K, Ishida T, Taguchi H, Tsuda Y, Okada Y, Okunomiya A, Wanaka K, Okamoto S.
    Biochem Biophys Res Commun; 1995 Aug 15; 213(2):583-7. PubMed ID: 7646515
    [Abstract] [Full Text] [Related]

  • 18. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.
    Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.
    Biochemistry; 1999 Jun 22; 38(25):7969-77. PubMed ID: 10387040
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
    Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD.
    Biochemistry; 1996 Mar 12; 35(10):3147-55. PubMed ID: 8605148
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