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Journal Abstract Search

251 related items for PubMed ID: 9083493

  • 1. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
    Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girotra NN, Kopka IE, Lanza TJ, Levorse DA, MacCoss M, Owens KA, Ponpipom MM, Simeone JP, Harrison RK, Niedzwiecki L, Becker JW, Marcy AI, Axel MG, Christen AJ, McDonnell J, Moore VL, Olszewski JM, Saphos C, Visco DM, Hagmann WK.
    J Med Chem; 1997 Mar 14; 40(6):1026-40. PubMed ID: 9083493
    [Abstract] [Full Text] [Related]

  • 2. Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.
    Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Chen L, Dunaway CM, Gu F, Mieling GE.
    J Med Chem; 1999 Jan 14; 42(1):87-94. PubMed ID: 9888835
    [Abstract] [Full Text] [Related]

  • 3. Matrix metalloproteinase inhibitors: a structure-activity study.
    Levy DE, Lapierre F, Liang W, Ye W, Lange CW, Li X, Grobelny D, Casabonne M, Tyrrell D, Holme K, Nadzan A, Galardy RE.
    J Med Chem; 1998 Jan 15; 41(2):199-223. PubMed ID: 9457244
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides.
    Chapman KT, Kopka IE, Durette PL, Esser CK, Lanza TJ, Izquierdo-Martin M, Niedzwiecki L, Chang B, Harrison RK, Kuo DW.
    J Med Chem; 1993 Dec 24; 36(26):4293-301. PubMed ID: 8277511
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  • 6. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.
    Tamura Y, Watanabe F, Nakatani T, Yasui K, Fuji M, Komurasaki T, Tsuzuki H, Maekawa R, Yoshioka T, Kawada K, Sugita K, Ohtani M.
    J Med Chem; 1998 Feb 12; 41(4):640-9. PubMed ID: 9484512
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
    Yamamoto M, Tsujishita H, Hori N, Ohishi Y, Inoue S, Ikeda S, Okada Y.
    J Med Chem; 1998 Apr 09; 41(8):1209-17. PubMed ID: 9548812
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  • 8. Discovery of potent, achiral matrix metalloproteinase inhibitors.
    Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE.
    J Med Chem; 1998 Sep 10; 41(19):3568-71. PubMed ID: 9733482
    [No Abstract] [Full Text] [Related]

  • 9. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.
    MacPherson LJ, Bayburt EK, Capparelli MP, Carroll BJ, Goldstein R, Justice MR, Zhu L, Hu S, Melton RA, Fryer L, Goldberg RL, Doughty JR, Spirito S, Blancuzzi V, Wilson D, O'Byrne EM, Ganu V, Parker DT.
    J Med Chem; 1997 Aug 01; 40(16):2525-32. PubMed ID: 9258358
    [Abstract] [Full Text] [Related]

  • 10. Potent, selective pyrone-based inhibitors of stromelysin-1.
    Puerta DT, Mongan J, Tran BL, McCammon JA, Cohen SM.
    J Am Chem Soc; 2005 Oct 19; 127(41):14148-9. PubMed ID: 16218585
    [Abstract] [Full Text] [Related]

  • 11. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.
    Fray MJ, Dickinson RP, Huggins JP, Occleston NL.
    J Med Chem; 2003 Jul 31; 46(16):3514-25. PubMed ID: 12877590
    [Abstract] [Full Text] [Related]

  • 12. Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.
    Chen L, Rydel TJ, Gu F, Dunaway CM, Pikul S, Dunham KM, Barnett BL.
    J Mol Biol; 1999 Oct 29; 293(3):545-57. PubMed ID: 10543949
    [Abstract] [Full Text] [Related]

  • 13. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.
    Tuccinardi T, Martinelli A, Nuti E, Carelli P, Balzano F, Uccello-Barretta G, Murphy G, Rossello A.
    Bioorg Med Chem; 2006 Jun 15; 14(12):4260-76. PubMed ID: 16483784
    [Abstract] [Full Text] [Related]

  • 14. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
    Yang W, Lu W, Lu Y, Zhong M, Sun J, Thomas AE, Wilkinson JM, Fucini RV, Lam M, Randal M, Shi XP, Jacobs JW, McDowell RS, Gordon EM, Ballinger MD.
    J Med Chem; 2006 Feb 09; 49(3):839-42. PubMed ID: 16451048
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  • 16. Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
    Monovich LG, Tommasi RA, Fujimoto RA, Blancuzzi V, Clark K, Cornell WD, Doti R, Doughty J, Fang J, Farley D, Fitt J, Ganu V, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Parker DT, Melton R, O'Byrne E, Pastor G, Pellas T, Quadros E, Reel N, Roland DM, Sakane Y, Singh H, Skiles J, Somers J, Toscano K, Wigg A, Zhou S, Zhu L, Shieh WC, Xue S, McQuire LW.
    J Med Chem; 2009 Jun 11; 52(11):3523-38. PubMed ID: 19422229
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