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Journal Abstract Search

215 related items for PubMed ID: 9092572

  • 1. Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I.
    Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L, Patton R, Windsor WT, Syto R, Zhang R, Bishop WR.
    J Biol Chem; 1997 Apr 11; 272(15):10232-9. PubMed ID: 9092572
    [Abstract] [Full Text] [Related]

  • 2. Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells.
    Bishop WR, Bond R, Petrin J, Wang L, Patton R, Doll R, Njoroge G, Catino J, Schwartz J, Windsor W.
    J Biol Chem; 1995 Dec 22; 270(51):30611-8. PubMed ID: 8530497
    [Abstract] [Full Text] [Related]

  • 3. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors.
    Whyte DB, Kirschmeier P, Hockenberry TN, Nunez-Oliva I, James L, Catino JJ, Bishop WR, Pai JK.
    J Biol Chem; 1997 May 30; 272(22):14459-64. PubMed ID: 9162087
    [Abstract] [Full Text] [Related]

  • 4. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26770-3. PubMed ID: 7592913
    [Abstract] [Full Text] [Related]

  • 5. Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.
    Zhang FL, Fu HW, Casey PJ, Bishop WR.
    Biochemistry; 1996 Jun 25; 35(25):8166-71. PubMed ID: 8679569
    [Abstract] [Full Text] [Related]

  • 6. Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice.
    Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Li Z, Dell J, Lipari P, Malkowski M, Prioli N, Rossman RR, Korfmacher WA, Nomeir AA, Lin CC, Mallams AK, Doll RJ, Catino JJ, Girijavallabhan VM, Kirschmeier P, Bishop WR.
    Cancer Chemother Pharmacol; 1999 Jun 25; 43(1):50-8. PubMed ID: 9923541
    [Abstract] [Full Text] [Related]

  • 7. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
    [Abstract] [Full Text] [Related]

  • 8. High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
    Fiordalisi JJ, Johnson RL, Weinbaum CA, Sakabe K, Chen Z, Casey PJ, Cox AD.
    J Biol Chem; 2003 Oct 24; 278(43):41718-27. PubMed ID: 12882980
    [Abstract] [Full Text] [Related]

  • 9. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.
    James GL, Goldstein JL, Brown MS.
    J Biol Chem; 1995 Mar 17; 270(11):6221-6. PubMed ID: 7890759
    [Abstract] [Full Text] [Related]

  • 10. Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.
    Kelly J, Wolin R, Connolly M, Afonso A, James L, Kirshmeier P, Bishop WR, McPhail AT.
    Bioorg Med Chem; 1998 Jun 17; 6(6):673-86. PubMed ID: 9681133
    [Abstract] [Full Text] [Related]

  • 11. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
    Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P.
    J Biol Chem; 2005 Sep 02; 280(35):31101-8. PubMed ID: 16006564
    [Abstract] [Full Text] [Related]

  • 12. Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor.
    O'Meara SJ, Kinsella BT.
    Br J Pharmacol; 2004 Sep 02; 143(2):318-30. PubMed ID: 15339863
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep 02; 15(11):1283-8. PubMed ID: 9315095
    [Abstract] [Full Text] [Related]

  • 14. Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.
    Njoroge FG, Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK.
    J Med Chem; 1997 Dec 19; 40(26):4290-301. PubMed ID: 9435898
    [Abstract] [Full Text] [Related]

  • 15. Natural inhibitors for protein prenyltransferase.
    Lee S, Park S, Oh JW, Yang C.
    Planta Med; 1998 May 19; 64(4):303-8. PubMed ID: 9619109
    [Abstract] [Full Text] [Related]

  • 16. Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I.
    Hicks KA, Hartman HL, Fierke CA.
    Biochemistry; 2005 Nov 22; 44(46):15325-33. PubMed ID: 16285736
    [Abstract] [Full Text] [Related]

  • 17. Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation.
    Yokoyama K, Zimmerman K, Scholten J, Gelb MH.
    J Biol Chem; 1997 Feb 14; 272(7):3944-52. PubMed ID: 9020098
    [Abstract] [Full Text] [Related]

  • 18. Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics.
    Cohen LH, Pieterman E, van Leeuwen RE, Overhand M, Burm BE, van der Marel GA, van Boom JH.
    Biochem Pharmacol; 2000 Oct 15; 60(8):1061-8. PubMed ID: 11007942
    [Abstract] [Full Text] [Related]

  • 19. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.
    Armstrong SA, Hannah VC, Goldstein JL, Brown MS.
    J Biol Chem; 1995 Apr 07; 270(14):7864-8. PubMed ID: 7713879
    [Abstract] [Full Text] [Related]

  • 20. Farnesyl protein transferase inhibitors as potential cancer chemopreventives.
    Kelloff GJ, Lubet RA, Fay JR, Steele VE, Boone CW, Crowell JA, Sigman CC.
    Cancer Epidemiol Biomarkers Prev; 1997 Apr 07; 6(4):267-82. PubMed ID: 9107432
    [Abstract] [Full Text] [Related]

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