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98 related items for PubMed ID: 9107387

  • 1. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria.
    Horn DM, Neeb LA, Colacino JM, Richardson FC.
    Antiviral Res; 1997 Mar; 34(1):71-4. PubMed ID: 9107387
    [Abstract] [Full Text] [Related]

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  • 3. Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU).
    Colacino JM.
    Antiviral Res; 1996 Mar; 29(2-3):125-39. PubMed ID: 8739593
    [Abstract] [Full Text] [Related]

  • 4. Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture.
    Colacino JM, Malcolm SK, Jaskunas SR.
    Antimicrob Agents Chemother; 1994 Sep; 38(9):1997-2002. PubMed ID: 7811009
    [Abstract] [Full Text] [Related]

  • 5. Priming of duck hepatitis B virus reverse transcription in vitro: premature termination of primer DNA induced by the 5'-triphosphate of fialuridine.
    Staschke KA, Colacino JM.
    J Virol; 1994 Dec; 68(12):8265-9. PubMed ID: 7525986
    [Abstract] [Full Text] [Related]

  • 6. Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.
    Lewis W, Meyer RR, Simpson JF, Colacino JM, Perrino FW.
    Biochemistry; 1994 Dec 06; 33(48):14620-4. PubMed ID: 7981224
    [Abstract] [Full Text] [Related]

  • 7. The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell.
    Staschke KA, Colacino JM, Mabry TE, Jones CD.
    Antiviral Res; 1994 Jan 06; 23(1):45-61. PubMed ID: 8141592
    [Abstract] [Full Text] [Related]

  • 8. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
    Cui L, Yoon S, Schinazi RF, Sommadossi JP.
    J Clin Invest; 1995 Feb 06; 95(2):555-63. PubMed ID: 7860738
    [Abstract] [Full Text] [Related]

  • 9. Mitochondrial and cellular toxicity induced by fialuridine in human muscle in vitro.
    Semino-Mora C, Leon-Monzon M, Dalakas MC.
    Lab Invest; 1997 Apr 06; 76(4):487-95. PubMed ID: 9111511
    [Abstract] [Full Text] [Related]

  • 10. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.
    Lai Y, Tse CM, Unadkat JD.
    J Biol Chem; 2004 Feb 06; 279(6):4490-7. PubMed ID: 14607828
    [Abstract] [Full Text] [Related]

  • 11. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax).
    Lewis W, Griniuviene B, Tankersley KO, Levine ES, Montione R, Engelman L, de Courten-Myers G, Ascenzi MA, Hornbuckle WE, Gerin JL, Tennant BC.
    Lab Invest; 1997 Jan 06; 76(1):77-87. PubMed ID: 9010451
    [Abstract] [Full Text] [Related]

  • 12. Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection.
    Tennant BC, Baldwin BH, Graham LA, Ascenzi MA, Hornbuckle WE, Rowland PH, Tochkov IA, Yeager AE, Erb HN, Colacino JM, Lopez C, Engelhardt JA, Bowsher RR, Richardson FC, Lewis W, Cote PJ, Korba BE, Gerin JL.
    Hepatology; 1998 Jul 06; 28(1):179-91. PubMed ID: 9657111
    [Abstract] [Full Text] [Related]

  • 13. Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.
    Wang J, Eriksson S.
    Antimicrob Agents Chemother; 1996 Jun 06; 40(6):1555-7. PubMed ID: 8726039
    [Abstract] [Full Text] [Related]

  • 14. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.
    Richardson FC, Engelhardt JA, Bowsher RR.
    Proc Natl Acad Sci U S A; 1994 Dec 06; 91(25):12003-7. PubMed ID: 7991573
    [Abstract] [Full Text] [Related]

  • 15. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.
    McKenzie R, Fried MW, Sallie R, Conjeevaram H, Di Bisceglie AM, Park Y, Savarese B, Kleiner D, Tsokos M, Luciano C.
    N Engl J Med; 1995 Oct 26; 333(17):1099-105. PubMed ID: 7565947
    [Abstract] [Full Text] [Related]

  • 16. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.
    Xu D, Nishimura T, Nishimura S, Zhang H, Zheng M, Guo YY, Masek M, Michie SA, Glenn J, Peltz G.
    PLoS Med; 2014 Apr 26; 11(4):e1001628. PubMed ID: 24736310
    [Abstract] [Full Text] [Related]

  • 17. Comparison of the DNA incorporation in human MOLT-4 cells of two 2'-beta-fluoronucleosides, 2'-beta-fluoro-2',3'-dideoxyadenosine and fialuridine.
    Ahluwalia GS, Driscoll JS, Ford H, Johns DG.
    J Pharm Sci; 1996 Apr 26; 85(4):454-5. PubMed ID: 8901088
    [Abstract] [Full Text] [Related]

  • 18. The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
    Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE.
    Toxicol Appl Pharmacol; 2020 Sep 15; 403():115163. PubMed ID: 32730777
    [Abstract] [Full Text] [Related]

  • 19. Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells.
    Klecker RW, Katki AG, Collins JM.
    Mol Pharmacol; 1994 Dec 15; 46(6):1204-9. PubMed ID: 7808443
    [Abstract] [Full Text] [Related]

  • 20. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.
    Lee EW, Lai Y, Zhang H, Unadkat JD.
    J Biol Chem; 2006 Jun 16; 281(24):16700-6. PubMed ID: 16595656
    [Abstract] [Full Text] [Related]

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