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233 related items for PubMed ID: 9109647

  • 1. NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
    Johnson JM, Meiering EM, Wright JE, Pardo J, Rosowsky A, Wagner G.
    Biochemistry; 1997 Apr 15; 36(15):4399-411. PubMed ID: 9109647
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  • 2. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
    Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Blakley RL.
    Biochemistry; 1997 Nov 11; 36(45):13897-903. PubMed ID: 9374868
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  • 3. Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
    Rosowsky A, Vaidya CM, Bader H, Wright JE, Teicher BA.
    J Med Chem; 1997 Jan 31; 40(3):286-99. PubMed ID: 9022795
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  • 4. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 31; 48(4):758-65. PubMed ID: 7476904
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  • 5. Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
    Cody V, Galitsky N, Luft JR, Pangborn W, Blakley RL, Gangjee A.
    Anticancer Drug Des; 1998 Jun 31; 13(4):307-15. PubMed ID: 9627670
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  • 6. Detection of long-lived bound water molecules in complexes of human dihydrofolate reductase with methotrexate and NADPH.
    Meiering EM, Wagner G.
    J Mol Biol; 1995 Mar 24; 247(2):294-308. PubMed ID: 7707376
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  • 7. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN.
    J Med Chem; 1998 Dec 17; 41(26):5310-9. PubMed ID: 9857098
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  • 8. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
    Cody V, Luft JR, Pangborn W.
    Acta Crystallogr D Biol Crystallogr; 2005 Feb 17; 61(Pt 2):147-55. PubMed ID: 15681865
    [Abstract] [Full Text] [Related]

  • 9. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr 17; 45(4):783-91. PubMed ID: 7514264
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  • 11. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
    Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF.
    Biochemistry; 1999 Apr 06; 38(14):4303-12. PubMed ID: 10194348
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  • 12. Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate.
    Cody V, Galitsky N, Luft JR, Pangborn W, Gangjee A, Devraj R, Queener SF, Blakley RL.
    Acta Crystallogr D Biol Crystallogr; 1997 Nov 01; 53(Pt 6):638-49. PubMed ID: 15299851
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  • 13. The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.
    Rosowsky A, Wright JE, Vaidya CM, Forsch RA.
    Pharmacol Ther; 2000 Mar 01; 85(3):191-205. PubMed ID: 10739874
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  • 18. Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole.
    Cody V, Luft JR, Ciszak E, Kalman TI, Freisheim JH.
    Anticancer Drug Des; 1992 Dec 01; 7(6):483-91. PubMed ID: 1285840
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  • 19. Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
    Jackson M, Chopra S, Smiley RD, Maynord PO, Rosowsky A, London RE, Levy L, Kalman TI, Howell EE.
    Biochemistry; 2005 Sep 20; 44(37):12420-33. PubMed ID: 16156655
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  • 20. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.
    Lee H, Reyes VM, Kraut J.
    Biochemistry; 1996 Jun 04; 35(22):7012-20. PubMed ID: 8679526
    [Abstract] [Full Text] [Related]

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