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103 related items for PubMed ID: 9114979

  • 1. Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.
    Shen S, Hargus SJ, Martin BM, Pohl LR.
    Chem Res Toxicol; 1997 Apr; 10(4):420-3. PubMed ID: 9114979
    [Abstract] [Full Text] [Related]

  • 2. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
    [Abstract] [Full Text] [Related]

  • 3. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [Abstract] [Full Text] [Related]

  • 4. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 5. Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity.
    Tang C, Shou M, Rodrigues AD.
    Drug Metab Dispos; 2000 May; 28(5):567-72. PubMed ID: 10772636
    [Abstract] [Full Text] [Related]

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  • 8. Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
    Masubuchi Y, Igarashi S, Suzuki T, Horie T, Narimatsu S.
    J Pharmacol Exp Ther; 1996 Nov; 279(2):724-31. PubMed ID: 8930177
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  • 10. Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.
    Narimatsu S, Tachibana M, Masubuchi Y, Suzuki T.
    Chem Res Toxicol; 1996 Nov; 9(1):93-8. PubMed ID: 8924622
    [Abstract] [Full Text] [Related]

  • 11. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct.
    Kretz-Rommel A, Boelsterli UA.
    Drug Metab Dispos; 1994 Nov; 22(6):956-61. PubMed ID: 7895615
    [Abstract] [Full Text] [Related]

  • 12. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase.
    Wienkers LC, Steenwyk RC, Mizsak SA, Pearson PG.
    Drug Metab Dispos; 1995 Mar; 23(3):383-92. PubMed ID: 7628305
    [Abstract] [Full Text] [Related]

  • 13. Sexual differentiation of cytochrome P-450 in rat liver. Evidence for a constitutive isozyme as the male-specific 16 alpha-hydroxylase.
    Morgan ET, MacGeoch C, Gustafsson JA.
    Mol Pharmacol; 1985 Apr; 27(4):471-9. PubMed ID: 3982392
    [Abstract] [Full Text] [Related]

  • 14. The substrate binding site of human liver cytochrome P450 2C9: an NMR study.
    Poli-Scaife S, Attias R, Dansette PM, Mansuy D.
    Biochemistry; 1997 Oct 21; 36(42):12672-82. PubMed ID: 9335524
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  • 15. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase.
    Draper AJ, Hammock BD.
    Arch Biochem Biophys; 2000 Apr 01; 376(1):199-205. PubMed ID: 10729206
    [Abstract] [Full Text] [Related]

  • 16. In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (+/-)-fluvastatin.
    Transon C, Leemann T, Vogt N, Dayer P.
    Clin Pharmacol Ther; 1995 Oct 01; 58(4):412-7. PubMed ID: 7586933
    [Abstract] [Full Text] [Related]

  • 17. CYP2C9 is a principal low-affinity phenacetin O-deethylase: fluvoxamine is not a specific CYP1A2 inhibitor.
    Venkatakrishnan K, von Moltke LL, Greenblatt DJ.
    Drug Metab Dispos; 1999 Dec 01; 27(12):1519-22. PubMed ID: 10627170
    [No Abstract] [Full Text] [Related]

  • 18. [Diminished activity of testosterone-16-alpha hydroxylase in bovine liver microsomes].
    Depelchin BO.
    Ann Rech Vet; 1984 Dec 01; 15(4):515-8. PubMed ID: 6529121
    [Abstract] [Full Text] [Related]

  • 19. Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
    Jousserandot A, Boucher JL, Henry Y, Niklaus B, Clement B, Mansuy D.
    Biochemistry; 1998 Dec 08; 37(49):17179-91. PubMed ID: 9860831
    [Abstract] [Full Text] [Related]

  • 20. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ, De Voss JJ, Hooper WD, Dickinson RG, Gillam EM.
    Chem Res Toxicol; 1997 Sep 08; 10(9):1049-58. PubMed ID: 9305589
    [Abstract] [Full Text] [Related]

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