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Journal Abstract Search

92 related items for PubMed ID: 9128144

  • 1. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
    Harlow GR, He YA, Halpert JR.
    Biochim Biophys Acta; 1997 Apr 04; 1338(2):259-66. PubMed ID: 9128144
    [Abstract] [Full Text] [Related]

  • 2. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
    Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1996 Feb 01; 326(1):85-92. PubMed ID: 8579377
    [Abstract] [Full Text] [Related]

  • 3. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
    John GH, Hasler JA, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Nov 01; 314(2):367-75. PubMed ID: 7979377
    [Abstract] [Full Text] [Related]

  • 4. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 01; 46(2):338-45. PubMed ID: 8078495
    [Abstract] [Full Text] [Related]

  • 5. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 6. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
    Waller SC, He YA, Harlow GR, He YQ, Mash EA, Halpert JR.
    Chem Res Toxicol; 1999 Aug 01; 12(8):690-9. PubMed ID: 10458702
    [Abstract] [Full Text] [Related]

  • 7. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

  • 8. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

  • 9. Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334.
    Talakad JC, Wilderman PR, Davydov DR, Kumar S, Halpert JR.
    Arch Biochem Biophys; 2010 Feb 15; 494(2):151-8. PubMed ID: 19944064
    [Abstract] [Full Text] [Related]

  • 10. Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.
    Szklarz GD, He YA, Halpert JR.
    Biochemistry; 1995 Nov 07; 34(44):14312-22. PubMed ID: 7578035
    [Abstract] [Full Text] [Related]

  • 11. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL, John GH, Harlow GR, Halpert JR.
    Drug Metab Dispos; 1995 Jul 07; 23(7):702-7. PubMed ID: 7587957
    [Abstract] [Full Text] [Related]

  • 12. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
    [Abstract] [Full Text] [Related]

  • 13. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
    Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ.
    Mol Pharmacol; 2004 May 15; 65(5):1278-85. PubMed ID: 15102956
    [Abstract] [Full Text] [Related]

  • 14. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
    Domanski TL, Schultz KM, Roussel F, Stevens JC, Halpert JR.
    J Pharmacol Exp Ther; 1999 Sep 15; 290(3):1141-7. PubMed ID: 10454488
    [Abstract] [Full Text] [Related]

  • 15. Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.
    Hanna IH, Teiber JF, Kokones KL, Hollenberg PF.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):324-32. PubMed ID: 9473308
    [Abstract] [Full Text] [Related]

  • 16. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH, Johnson EF.
    J Biol Chem; 1994 Sep 30; 269(39):23937-43. PubMed ID: 7929041
    [Abstract] [Full Text] [Related]

  • 17. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
    [Abstract] [Full Text] [Related]

  • 18. Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.
    Omata Y, Sakamoto H, Robinson RC, Pincus MR, Friedman FK.
    Biochem Biophys Res Commun; 1994 Jun 30; 201(3):1090-5. PubMed ID: 8024550
    [Abstract] [Full Text] [Related]

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  • 20. The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.
    Domanski TL, He YQ, Scott EE, Wang Q, Halpert JR.
    Arch Biochem Biophys; 2001 Oct 01; 394(1):21-8. PubMed ID: 11566023
    [Abstract] [Full Text] [Related]

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