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200 related items for PubMed ID: 9144636

  • 1. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors.
    Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Mayne NG, Wu S, Cockerman SL, Burnett JP, Belegaje R, Bleakman D, Monn JA.
    Neuropharmacology; 1997 Jan; 36(1):1-11. PubMed ID: 9144636
    [Abstract] [Full Text] [Related]

  • 2. Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist.
    Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Monn JA.
    Naunyn Schmiedebergs Arch Pharmacol; 1998 Aug; 358(2):175-80. PubMed ID: 9750002
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
    Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD.
    J Med Chem; 1999 Mar 25; 42(6):1027-40. PubMed ID: 10090786
    [Abstract] [Full Text] [Related]

  • 4. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
    Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD.
    J Pharmacol Exp Ther; 2007 Apr 25; 321(1):308-17. PubMed ID: 17204749
    [Abstract] [Full Text] [Related]

  • 5. Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.
    Linden AM, Shannon H, Baez M, Yu JL, Koester A, Schoepp DD.
    Psychopharmacology (Berl); 2005 Apr 25; 179(1):284-91. PubMed ID: 15619115
    [Abstract] [Full Text] [Related]

  • 6. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.
    Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD.
    Neuropharmacology; 1998 Apr 25; 37(1):1-12. PubMed ID: 9680254
    [Abstract] [Full Text] [Related]

  • 7. The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
    Schoepp DD, Salhoff CR, Wright RA, Johnson BG, Burnett JP, Mayne NG, Belagaje R, Wu S, Monn JA.
    Neuropharmacology; 1996 Apr 25; 35(12):1661-72. PubMed ID: 9076745
    [Abstract] [Full Text] [Related]

  • 8. Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist.
    Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.
    J Med Chem; 2005 May 19; 48(10):3605-12. PubMed ID: 15887967
    [Abstract] [Full Text] [Related]

  • 9. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.
    Cartmell J, Monn JA, Schoepp DD.
    J Pharmacol Exp Ther; 1999 Oct 19; 291(1):161-70. PubMed ID: 10490900
    [Abstract] [Full Text] [Related]

  • 10. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.
    Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK.
    J Pharmacol Exp Ther; 2000 Jan 19; 292(1):76-87. PubMed ID: 10604933
    [Abstract] [Full Text] [Related]

  • 11. In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain.
    Schaffhauser H, Richards JG, Cartmell J, Chaboz S, Kemp JA, Klingelschmidt A, Messer J, Stadler H, Woltering T, Mutel V.
    Mol Pharmacol; 1998 Feb 19; 53(2):228-33. PubMed ID: 9463480
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  • 13. Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain.
    Felder CC, Schober DA, Tu Y, Quets A, Xiao H, Watt M, Siuda E, Nisenbaum E, Xiang C, Heinz B, Prieto L, McKinzie DL, Monn JA.
    J Pharmacol Exp Ther; 2017 Apr 19; 361(1):190-197. PubMed ID: 28138041
    [Abstract] [Full Text] [Related]

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  • 15. Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.
    Schweitzer C, Kratzeisen C, Adam G, Lundstrom K, Malherbe P, Ohresser S, Stadler H, Wichmann J, Woltering T, Mutel V.
    Neuropharmacology; 2000 Jul 24; 39(10):1700-6. PubMed ID: 10884552
    [Abstract] [Full Text] [Related]

  • 16. In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist.
    Witkin JM, Ornstein PL, Mitch CH, Li R, Smith SC, Heinz BA, Wang XS, Xiang C, Carter JH, Anderson WH, Li X, Broad LM, Pasqui F, Fitzjohn SM, Sanger HE, Smith JL, Catlow J, Swanson S, Monn JA.
    Neuropharmacology; 2017 Mar 15; 115():100-114. PubMed ID: 26748052
    [Abstract] [Full Text] [Related]

  • 17. Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices.
    Schaffhauser H, Cartmell J, Jakob-Røtne R, Mutel V.
    Neuropharmacology; 1997 Jul 15; 36(7):933-40. PubMed ID: 9257937
    [Abstract] [Full Text] [Related]

  • 18. Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.
    Wright RA, Schoepp DD.
    Eur J Pharmacol; 1996 Feb 22; 297(3):275-82. PubMed ID: 8666060
    [Abstract] [Full Text] [Related]

  • 19. Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR.
    Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, Findlay JD, Vivier RG, Sher E, Lodge D, Monn JA, Broad LM.
    Neuropharmacology; 2013 Mar 22; 66():264-73. PubMed ID: 22659090
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