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135 related items for PubMed ID: 9153192

  • 1. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
    Finder JD, Litz JL, Blaskovich MA, McGuire TF, Qian Y, Hamilton AD, Davies P, Sebti SM.
    J Biol Chem; 1997 May 23; 272(21):13484-8. PubMed ID: 9153192
    [Abstract] [Full Text] [Related]

  • 2. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P.
    Am J Physiol; 1998 Jul 23; 275(1):L55-63. PubMed ID: 9688935
    [Abstract] [Full Text] [Related]

  • 3. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
    Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM.
    Oncogene; 1996 Nov 07; 13(9):1991-9. PubMed ID: 8934546
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep 07; 15(11):1283-8. PubMed ID: 9315095
    [Abstract] [Full Text] [Related]

  • 5. Regulation of interleukin-1-beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells by hemostatic proteins.
    Durante W, Kroll MH, Orloff GJ, Cunningham JM, Scott-Burden T, Vanhoutte PM, Schafer AI.
    Biochem Pharmacol; 1996 Mar 22; 51(6):847-53. PubMed ID: 8602881
    [Abstract] [Full Text] [Related]

  • 6. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
    McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM.
    J Biol Chem; 1996 Nov 01; 271(44):27402-7. PubMed ID: 8910319
    [Abstract] [Full Text] [Related]

  • 7. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1998 Mar 01; 16(11):1467-73. PubMed ID: 9525745
    [Abstract] [Full Text] [Related]

  • 8. Calcium and protein kinase C mediate high-glucose-induced inhibition of inducible nitric oxide synthase in vascular smooth muscle cells.
    Muniyappa R, Srinivas PR, Ram JL, Walsh MF, Sowers JR.
    Hypertension; 1998 Jan 01; 31(1 Pt 2):289-95. PubMed ID: 9453318
    [Abstract] [Full Text] [Related]

  • 9. Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
    Boota A, Johnson B, Lee KL, Blaskovich MA, Liu SX, Kagan VE, Hamilton A, Pitt B, Sebti SM, Davies P.
    Am J Physiol Lung Cell Mol Physiol; 2000 Feb 01; 278(2):L329-34. PubMed ID: 10666117
    [Abstract] [Full Text] [Related]

  • 10. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26770-3. PubMed ID: 7592913
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production.
    Zuckerbraun BS, Barbato JE, Hamilton A, Sebti S, Tzeng E.
    J Surg Res; 2005 Apr 10; 124(2):256-63. PubMed ID: 15820256
    [Abstract] [Full Text] [Related]

  • 12. Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells.
    Finder JD, Petrus JL, Hamilton A, Villavicencio RT, Pitt BR, Sebti SM.
    Am J Physiol Lung Cell Mol Physiol; 2001 Oct 10; 281(4):L816-23. PubMed ID: 11557585
    [Abstract] [Full Text] [Related]

  • 13. beta-very low density lipoprotein enhances inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells.
    Takahashi M, Takahashi S, Shimpo M, Naito A, Ogata Y, Kobayashi E, Ikeda U, Shimada K.
    Atherosclerosis; 2002 Jun 10; 162(2):307-13. PubMed ID: 11996950
    [Abstract] [Full Text] [Related]

  • 14. Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
    Abeles AM, Marjanovic N, Park J, Attur M, Chan ES, Al-Mussawir HE, Dave M, Fisher MC, Stuchin SA, Abramson SB, Pillinger MH.
    Arthritis Rheum; 2007 Sep 10; 56(9):2840-53. PubMed ID: 17763406
    [Abstract] [Full Text] [Related]

  • 15. Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive rats.
    Singh A, Sventek P, Larivière R, Thibault G, Schiffrin EL.
    Am J Hypertens; 1996 Sep 10; 9(9):867-77. PubMed ID: 8879343
    [Abstract] [Full Text] [Related]

  • 16. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
    Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26802-6. PubMed ID: 7592920
    [Abstract] [Full Text] [Related]

  • 17. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
    Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1997 Oct 24; 272(43):27224-9. PubMed ID: 9341167
    [Abstract] [Full Text] [Related]

  • 18. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
    [Abstract] [Full Text] [Related]

  • 19. High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
    Fiordalisi JJ, Johnson RL, Weinbaum CA, Sakabe K, Chen Z, Casey PJ, Cox AD.
    J Biol Chem; 2003 Oct 24; 278(43):41718-27. PubMed ID: 12882980
    [Abstract] [Full Text] [Related]

  • 20. Halothane but not isoflurane attenuates interleukin 1beta-induced nitric oxide synthase in vascular smooth muscle.
    Maeda H, Iranami H, Yamamoto M, Ogawa K, Morikawa Y, Senba E, Hatano Y.
    Anesthesiology; 2001 Aug 24; 95(2):492-9. PubMed ID: 11506125
    [Abstract] [Full Text] [Related]

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