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239 related items for PubMed ID: 9173929

  • 1. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 3. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
    Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C.
    Biochemistry; 1998 Feb 24; 37(8):2263-70. PubMed ID: 9485372
    [Abstract] [Full Text] [Related]

  • 4. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ.
    Neurobiol Dis; 1998 Aug 24; 5(2):107-16. PubMed ID: 9746908
    [Abstract] [Full Text] [Related]

  • 5. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 24; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 6. Presenilin-1 protein expression in familial and sporadic Alzheimer's disease.
    Levey AI, Heilman CJ, Lah JJ, Nash NR, Rees HD, Wakai M, Mirra SS, Rye DB, Nochlin D, Bird TD, Mufson EJ.
    Ann Neurol; 1997 Jun 24; 41(6):742-53. PubMed ID: 9189035
    [Abstract] [Full Text] [Related]

  • 7. Stable association of presenilin derivatives and absence of presenilin interactions with APP.
    Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS.
    Neurobiol Dis; 1998 Apr 24; 4(6):438-53. PubMed ID: 9666482
    [Abstract] [Full Text] [Related]

  • 8. Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines.
    Shirotani K, Takahashi K, Ozawa K, Kunishita T, Tabira T.
    Biochem Biophys Res Commun; 1997 Nov 26; 240(3):728-31. PubMed ID: 9398634
    [Abstract] [Full Text] [Related]

  • 9. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
    Walter J, Grünberg J, Schindzielorz A, Haass C.
    Biochemistry; 1998 Apr 28; 37(17):5961-7. PubMed ID: 9558331
    [Abstract] [Full Text] [Related]

  • 10. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov 28; 95(3):880-90. PubMed ID: 16135086
    [Abstract] [Full Text] [Related]

  • 11. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S, Haass C, Steiner H.
    J Neurochem; 2005 Jul 28; 94(1):57-62. PubMed ID: 15953349
    [Abstract] [Full Text] [Related]

  • 12. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA, Perez-Tur J, Golde TE, Hardy J.
    Biochem Biophys Res Commun; 2000 Oct 14; 277(1):261-3. PubMed ID: 11027672
    [Abstract] [Full Text] [Related]

  • 13. Presenilins and Alzheimer's disease: the role of A beta 42.
    Eckman CB.
    J Neural Transm Suppl; 1998 Oct 14; 53():181-4. PubMed ID: 9700656
    [Abstract] [Full Text] [Related]

  • 14. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug 14; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 15. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec 14; 1(8):479-85. PubMed ID: 10587643
    [Abstract] [Full Text] [Related]

  • 16. Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
    Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.
    J Neurosci Res; 2004 Feb 01; 75(3):417-28. PubMed ID: 14743455
    [Abstract] [Full Text] [Related]

  • 17. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 01; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 18. Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.
    Tomidokoro Y, Ishiguro K, Igeta Y, Matsubara E, Kanai M, Shizuka M, Kawarabayashi T, Harigaya Y, Kawakatsu S, Ii K, Ikeda M, St George-Hyslop PH, Hirai S, Okamoto K, Shoji M.
    Biochem Biophys Res Commun; 1999 Mar 24; 256(3):512-8. PubMed ID: 10080929
    [Abstract] [Full Text] [Related]

  • 19. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J.
    J Neurochem; 2004 Apr 24; 89(1):44-53. PubMed ID: 15030388
    [Abstract] [Full Text] [Related]

  • 20. Presenilins upregulate functional K+ channel currents in mammalian cells.
    Malin SA, Guo WX, Jafari G, Goate AM, Nerbonne JM.
    Neurobiol Dis; 1998 Apr 24; 4(6):398-409. PubMed ID: 9666479
    [Abstract] [Full Text] [Related]

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