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Journal Abstract Search

196 related items for PubMed ID: 9186496

  • 1. Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase.
    Reilly RT, Forsthoefel AM, Berger FG.
    Arch Biochem Biophys; 1997 Jun 15; 342(2):338-43. PubMed ID: 9186496
    [Abstract] [Full Text] [Related]

  • 2. Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase.
    Reilly RT, Barbour KW, Dunlap RB, Berger FG.
    Mol Pharmacol; 1995 Jul 15; 48(1):72-9. PubMed ID: 7623777
    [Abstract] [Full Text] [Related]

  • 3. Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.
    Mahdavian E, Spencer HT, Dunlap RB.
    Arch Biochem Biophys; 1999 Aug 15; 368(2):257-64. PubMed ID: 10441376
    [Abstract] [Full Text] [Related]

  • 4. Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
    Hughey CT, Barbour KW, Berger FG, Berger SH.
    Mol Pharmacol; 1993 Aug 15; 44(2):316-23. PubMed ID: 8355668
    [Abstract] [Full Text] [Related]

  • 5. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
    Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan J, Minor W, Lebioda L, Berger FG, Spencer HT.
    Mol Pharmacol; 2000 Feb 15; 57(2):359-66. PubMed ID: 10648646
    [Abstract] [Full Text] [Related]

  • 6. A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase.
    Williams AW, Dunlap RB, Berger SH.
    Biochemistry; 1998 May 19; 37(20):7096-102. PubMed ID: 9585520
    [Abstract] [Full Text] [Related]

  • 7. Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.
    Landis DM, Heindel CC, Loeb LA.
    Cancer Res; 2001 Jan 15; 61(2):666-72. PubMed ID: 11212266
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  • 9. Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.
    Davis ST, Berger SH.
    Mol Pharmacol; 1993 May 15; 43(5):702-8. PubMed ID: 8502227
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  • 11. Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.
    Steadman DJ, Spencer HT, Dunlap RB, Berger SH.
    Biochemistry; 1999 Apr 27; 38(17):5582-7. PubMed ID: 10220346
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  • 12. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
    Hyatt DC, Maley F, Montfort WR.
    Biochemistry; 1997 Apr 15; 36(15):4585-94. PubMed ID: 9109668
    [Abstract] [Full Text] [Related]

  • 13. A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.
    Barbour KW, Hoganson DK, Berger SH, Berger FG.
    Mol Pharmacol; 1992 Aug 15; 42(2):242-8. PubMed ID: 1355260
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  • 15. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
    Sage CR, Michelitsch MD, Stout TJ, Biermann D, Nissen R, Finer-Moore J, Stroud RM.
    Biochemistry; 1998 Sep 29; 37(39):13893-901. PubMed ID: 9753479
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  • 17. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
    Spears CP, Shahinian AH, Moran RG, Heidelberger C, Corbett TH.
    Cancer Res; 1982 Feb 29; 42(2):450-6. PubMed ID: 6173112
    [Abstract] [Full Text] [Related]

  • 18. Properties of a defined mutant of Escherichia coli thymidylate synthase.
    Maley GF, Maley F.
    J Biol Chem; 1988 Jun 05; 263(16):7620-7. PubMed ID: 3286637
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  • 19. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
    Spears CP, Hayes AA, Shahinian AH, Danenberg PV, Frösing R, Gustavsson BG.
    Biochem Pharmacol; 1989 Sep 15; 38(18):2985-93. PubMed ID: 2783153
    [Abstract] [Full Text] [Related]

  • 20. A structural role for glutamine 214 in human thymidylate synthase.
    Steadman DJ, Zhao PS, Spencer HT, Dunlap RB, Berger SH.
    Biochemistry; 1998 May 19; 37(20):7089-95. PubMed ID: 9585519
    [Abstract] [Full Text] [Related]

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