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2. Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates. Whitehead SS, Hill MG, Firestone CY, St Claire M, Elkins WR, Murphy BR, Collins PL. J Virol; 1999 Dec; 73(12):9773-80. PubMed ID: 10559287 [Abstract] [Full Text] [Related]
3. The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivo. Crowe JE, Randolph V, Murphy BR. Virus Res; 1999 Jan; 59(1):13-22. PubMed ID: 10854162 [Abstract] [Full Text] [Related]
4. Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity. Whitehead SS, Firestone CY, Karron RA, Crowe JE, Elkins WR, Collins PL, Murphy BR. J Virol; 1999 Feb; 73(2):871-7. PubMed ID: 9882287 [Abstract] [Full Text] [Related]
6. The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein. Juhasz K, Whitehead SS, Bui PT, Biggs JM, Crowe JE, Boulanger CA, Collins PL, Murphy BR. J Virol; 1997 Aug; 71(8):5814-9. PubMed ID: 9223470 [Abstract] [Full Text] [Related]
7. Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant. Karron RA, Buonagurio DA, Georgiu AF, Whitehead SS, Adamus JE, Clements-Mann ML, Harris DO, Randolph VB, Udem SA, Murphy BR, Sidhu MS. Proc Natl Acad Sci U S A; 1997 Dec 09; 94(25):13961-6. PubMed ID: 9391135 [Abstract] [Full Text] [Related]
9. Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus. Hsu KH, Crowe JE, Lubeck MD, Davis AR, Hung PP, Chanock RM, Murphy BR. Vaccine; 1995 Apr 09; 13(5):509-15. PubMed ID: 7543716 [Abstract] [Full Text] [Related]
10. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. Crowe JE, Bui PT, London WT, Davis AR, Hung PP, Chanock RM, Murphy BR. Vaccine; 1994 Jun 09; 12(8):691-9. PubMed ID: 8091846 [Abstract] [Full Text] [Related]
11. A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV. Crowe JE, Collins PL, London WT, Chanock RM, Murphy BR. Vaccine; 1993 Nov 09; 11(14):1395-404. PubMed ID: 8310760 [Abstract] [Full Text] [Related]
12. Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. Bukreyev A, Whitehead SS, Murphy BR, Collins PL. J Virol; 1997 Dec 09; 71(12):8973-82. PubMed ID: 9371553 [Abstract] [Full Text] [Related]
16. A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes. Whitehead SS, Firestone CY, Collins PL, Murphy BR. Virology; 1998 Aug 01; 247(2):232-9. PubMed ID: 9705916 [Abstract] [Full Text] [Related]
20. Temperature-sensitive hepatitis A virus mutants with deletions downstream of the first pyrimidine-rich tract of the 5' nontranslated RNA are impaired in RNA synthesis. Shaffer DR, Lemon SM. J Virol; 1995 Oct 01; 69(10):6498-506. PubMed ID: 7666551 [Abstract] [Full Text] [Related] Page: [Next] [New Search]