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Journal Abstract Search

185 related items for PubMed ID: 9212102

  • 1. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
    Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS.
    Nat Med; 1997 Jul; 3(7):756-60. PubMed ID: 9212102
    [Abstract] [Full Text] [Related]

  • 2. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
    Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS.
    Neuron; 1996 Jul; 17(1):181-90. PubMed ID: 8755489
    [Abstract] [Full Text] [Related]

  • 3. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC, Ghadge GD, Miller RJ, Roos RP.
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [Abstract] [Full Text] [Related]

  • 4. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
    Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE.
    Mol Med; 1999 Aug; 5(8):542-54. PubMed ID: 10501657
    [Abstract] [Full Text] [Related]

  • 5. Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
    Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR.
    J Biol Chem; 1997 Sep 26; 272(39):24536-41. PubMed ID: 9305918
    [Abstract] [Full Text] [Related]

  • 6. Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes.
    Takahashi H, Mercken M, Honda T, Saito Y, Murayama M, Song S, Takashima A.
    Neurosci Lett; 1999 Jan 29; 260(2):121-4. PubMed ID: 10025714
    [Abstract] [Full Text] [Related]

  • 7. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
    Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC.
    Neuron; 1998 Mar 29; 20(3):603-9. PubMed ID: 9539132
    [Abstract] [Full Text] [Related]

  • 8. Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing.
    Borchelt DR.
    Neurobiol Aging; 1998 Mar 29; 19(1 Suppl):S15-8. PubMed ID: 9562461
    [Abstract] [Full Text] [Related]

  • 9. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
    Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, Fraser PE, Andreadis A, Nixon RA.
    Mol Med; 2000 Oct 29; 6(10):878-91. PubMed ID: 11126202
    [Abstract] [Full Text] [Related]

  • 10. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
    Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G.
    Nat Cell Biol; 2000 Dec 29; 2(12):863-70. PubMed ID: 11146649
    [Abstract] [Full Text] [Related]

  • 11. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
    Parent A, Linden DJ, Sisodia SS, Borchelt DR.
    Neurobiol Dis; 1999 Feb 29; 6(1):56-62. PubMed ID: 10078973
    [Abstract] [Full Text] [Related]

  • 12. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997 Feb 29; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 13. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
    Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C.
    Biochemistry; 1999 Nov 02; 38(44):14600-5. PubMed ID: 10545183
    [Abstract] [Full Text] [Related]

  • 14. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
    Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS.
    Neuron; 1996 Nov 02; 17(5):1005-13. PubMed ID: 8938131
    [Abstract] [Full Text] [Related]

  • 15. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug 02; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 16. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
    Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS.
    Neuron; 1997 Oct 02; 19(4):939-45. PubMed ID: 9354339
    [Abstract] [Full Text] [Related]

  • 17. Implications of presenilin 1 mutations in Alzheimer's disease.
    Komano H, Sudoh S, Kawamura Y, Wang R, Yanagisawa K.
    Mech Ageing Dev; 1999 Mar 15; 107(3):281-98. PubMed ID: 10360683
    [Abstract] [Full Text] [Related]

  • 18. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 19. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
    Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G.
    J Biol Chem; 1999 May 14; 274(20):13818-23. PubMed ID: 10318786
    [Abstract] [Full Text] [Related]

  • 20. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.
    Xie Z, Romano DM, Tanzi RE.
    J Mol Neurosci; 2005 May 14; 25(1):67-77. PubMed ID: 15781968
    [Abstract] [Full Text] [Related]

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