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189 related items for PubMed ID: 9217260

  • 1. Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
    De Simone G, Balliano G, Milla P, Gallina C, Giordano C, Tarricone C, Rizzi M, Bolognesi M, Ascenzi P.
    J Mol Biol; 1997 Jun 20; 269(4):558-69. PubMed ID: 9217260
    [Abstract] [Full Text] [Related]

  • 2. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
    [Abstract] [Full Text] [Related]

  • 3. N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester: a novel, high selective and optimal chromogenic active site titrant for human and bovine alpha-, beta- and gamma-thrombin.
    Balliano G, Milla P, Giordano C, Gallina C, Coletta M, Menegatti E, Rizzi M, Bolognesi M, Ascenzi P.
    Biochem Biophys Res Commun; 1996 Aug 14; 225(2):557-61. PubMed ID: 8753800
    [Abstract] [Full Text] [Related]

  • 4. Thrombin inhibition by the highly selective 'reversible suicide substrate' N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester.
    Ascenzi P, Gallina C, Bolognesi M.
    Protein Pept Lett; 2005 Jul 14; 12(5):433-8. PubMed ID: 16029155
    [Abstract] [Full Text] [Related]

  • 5. Serine proteinase inhibition by the active site titrant N alpha-(N, N-dimethylcarbamoyl)-alpha-azaornithine p-nitrophenyl ester. A comparative study.
    Ascenzi P, Balliano G, Gallina C, Polticelli F, Bolognesi M.
    Eur J Biochem; 2000 Feb 14; 267(4):1239-46. PubMed ID: 10672036
    [Abstract] [Full Text] [Related]

  • 6. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 11. Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
    Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.
    Biochemistry; 1998 May 12; 37(19):6645-57. PubMed ID: 9578548
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  • 12. Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.
    Boatman PD, Ogbu CO, Eguchi M, Kim HO, Nakanishi H, Cao B, Shea JP, Kahn M.
    J Med Chem; 1999 Apr 22; 42(8):1367-75. PubMed ID: 10212122
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  • 13. Proton inventory studies of alpha-thrombin-catalyzed reactions of substrates with selected P and P' sites.
    Enyedy EJ, Kovach IM.
    J Am Chem Soc; 2004 May 19; 126(19):6017-24. PubMed ID: 15137766
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  • 14. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
    Skrzypczak-Jankun E, Carperos VE, Ravichandran KG, Tulinsky A, Westbrook M, Maraganore JM.
    J Mol Biol; 1991 Oct 20; 221(4):1379-93. PubMed ID: 1942057
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  • 15. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
    Rupin A, Mennecier P, Lila C, de Nanteuil G, Verbeuren TJ.
    Thromb Haemost; 1997 Oct 20; 78(4):1221-7. PubMed ID: 9364988
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  • 16. Inhibition of bovine beta-trypsin, human alpha-thrombin and porcine pancreatic beta-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: thermodynamic and molecular modeling study.
    Menegatti E, Ferroni R, Nastruzzi C, Bortolotti F, Scalia S, Amiconi G, Bolognesi M, Coletta M, Onesti S, Fruttero R.
    Farmaco; 1991 Nov 20; 46(11):1297-310. PubMed ID: 1811616
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  • 17. Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.
    Biochemistry; 2003 Aug 05; 42(30):9013-21. PubMed ID: 12885234
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  • 18. Synthesis and SAR of thrombin inhibitors incorporating a novel 4-amino-morpholinone sscaffold: analysis of X-ray crystal structure of enzyme inhibitor complex.
    Nilsson JW, Kvarnström I, Musil D, Nilsson I, Samulesson B.
    J Med Chem; 2003 Sep 11; 46(19):3985-4001. PubMed ID: 12954052
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  • 19. Molecular modeling and 3D-QSAR studies on the interaction mechanism of tripeptidyl thrombin inhibitors with human alpha-thrombin.
    Jiang H, Chen K, Tang Y, Chen J, Li Q, Wang Q, Ji R.
    J Med Chem; 1997 Sep 12; 40(19):3085-90. PubMed ID: 9301672
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  • 20. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

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