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Journal Abstract Search

202 related items for PubMed ID: 9219501

  • 21. Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ.
    J Med Chem; 2003 Apr 24; 46(9):1690-705. PubMed ID: 12699387
    [Abstract] [Full Text] [Related]

  • 22. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
    Niculescu-Duvaz I, Scanlon I, Niculescu-Duvaz D, Friedlos F, Martin J, Marais R, Springer CJ.
    J Med Chem; 2004 May 06; 47(10):2651-8. PubMed ID: 15115406
    [Abstract] [Full Text] [Related]

  • 23. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Dowell R, Burke PJ, Hadley E, Davis DH, Blakey DC, Melton RG, Niculescu-Duvaz I.
    J Med Chem; 1995 Dec 22; 38(26):5051-65. PubMed ID: 8544182
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  • 25. Identification of prodrug, active drug, and metabolites in an ADEPT clinical study.
    Springer CJ, Poon GK, Sharma SK, Bagshawe KD.
    Cell Biophys; 1993 Dec 22; 22(1-3):9-26. PubMed ID: 7889545
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  • 26. Antibody directed enzyme prodrug therapy (ADEPT): a three phase system.
    Sharma SK, Bagshawe KD, Springer CJ, Burke PJ, Rogers GT, Boden JA, Antoniw P, Melton RG, Sherwood RF.
    Dis Markers; 1991 Dec 22; 9(3-4):225-31. PubMed ID: 1813212
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  • 27. Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
    Masterson LA, Spanswick VJ, Hartley JA, Begent RH, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):252-6. PubMed ID: 16290933
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  • 28. New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
    Dowell RI, Springer CJ, Davies DH, Hadley EM, Burke PJ, Boyle FT, Melton RG, Connors TA, Blakey DC, Mauger AB.
    J Med Chem; 1996 Mar 01; 39(5):1100-5. PubMed ID: 8676345
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  • 30. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
    Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ.
    Cancer Res; 2007 May 15; 67(10):4949-55. PubMed ID: 17510425
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  • 33. A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19F magnetic resonance spectroscopy.
    Mancini L, Davies L, Friedlos F, Falck-Miniotis M, Dzik-Jurasz AS, Springer CJ, Leach MO, Payne GS.
    NMR Biomed; 2009 Jun 15; 22(5):561-6. PubMed ID: 19259950
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  • 34. Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect.
    Stribbling SM, Friedlos F, Martin J, Davies L, Spooner RA, Marais R, Springer CJ.
    Hum Gene Ther; 2000 Jan 20; 11(2):285-92. PubMed ID: 10680842
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  • 36. Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy.
    Sharma SK, Pedley RB, Bhatia J, Boxer GM, El-Emir E, Qureshi U, Tolner B, Lowe H, Michael NP, Minton N, Begent RH, Chester KA.
    Clin Cancer Res; 2005 Jan 15; 11(2 Pt 1):814-25. PubMed ID: 15701872
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  • 38. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
    Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ.
    J Med Chem; 1999 Mar 25; 42(6):951-6. PubMed ID: 10090777
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  • 40. Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy.
    Springer CJ, Niculescu-Duvaz I, Pedley RB.
    J Med Chem; 1994 Jul 22; 37(15):2361-70. PubMed ID: 8057284
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