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Journal Abstract Search

426 related items for PubMed ID: 9220969

  • 1. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA, He YQ, Szklarz GD, Halpert JR.
    Biochemistry; 1997 Jul 22; 36(29):8831-9. PubMed ID: 9220969
    [Abstract] [Full Text] [Related]

  • 2. Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.
    Domanski TL, Liu J, Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):223-32. PubMed ID: 9473295
    [Abstract] [Full Text] [Related]

  • 3. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
    He YQ, Roussel F, Halpert JR.
    Arch Biochem Biophys; 2001 May 15; 389(2):264-70. PubMed ID: 11339816
    [Abstract] [Full Text] [Related]

  • 4. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
    Domanski TL, He YA, Harlow GR, Halpert JR.
    J Pharmacol Exp Ther; 2000 May 15; 293(2):585-91. PubMed ID: 10773032
    [Abstract] [Full Text] [Related]

  • 5. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P, Johnson EF, Kemper B.
    Arch Biochem Biophys; 1993 Nov 01; 306(2):521-7. PubMed ID: 8215458
    [Abstract] [Full Text] [Related]

  • 6. Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity.
    Harlow GR, Halpert JR.
    J Biol Chem; 1997 Feb 28; 272(9):5396-402. PubMed ID: 9038138
    [Abstract] [Full Text] [Related]

  • 7. The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.
    Roussel F, Khan KK, Halpert JR.
    Arch Biochem Biophys; 2000 Feb 15; 374(2):269-78. PubMed ID: 10666307
    [Abstract] [Full Text] [Related]

  • 8. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
    Matsunaga I, Ueda A, Sumimoto T, Ichihara K, Ayata M, Ogura H.
    Arch Biochem Biophys; 2001 Oct 01; 394(1):45-53. PubMed ID: 11566026
    [Abstract] [Full Text] [Related]

  • 9. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

  • 10. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
    [Abstract] [Full Text] [Related]

  • 11. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

  • 12. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.
    Gillam EM, Baba T, Kim BR, Ohmori S, Guengerich FP.
    Arch Biochem Biophys; 1993 Aug 15; 305(1):123-31. PubMed ID: 8342945
    [Abstract] [Full Text] [Related]

  • 13. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 15; 46(2):338-45. PubMed ID: 8078495
    [Abstract] [Full Text] [Related]

  • 14. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
    Yamazaki H, Shaw PM, Guengerich FP, Shimada T.
    Chem Res Toxicol; 1998 Jun 15; 11(6):659-65. PubMed ID: 9625734
    [Abstract] [Full Text] [Related]

  • 15. Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
    Ueng YF, Kuwabara T, Chun YJ, Guengerich FP.
    Biochemistry; 1997 Jan 14; 36(2):370-81. PubMed ID: 9003190
    [Abstract] [Full Text] [Related]

  • 16. Application of 3-dimensional homology modeling of cytochrome P450 2B1 for interpretation of site-directed mutagenesis results.
    Szklarz GD, Ornstein RL, Halpert JR.
    J Biomol Struct Dyn; 1994 Aug 14; 12(1):061-78. PubMed ID: 7848559
    [Abstract] [Full Text] [Related]

  • 17. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL, John GH, Harlow GR, Halpert JR.
    Drug Metab Dispos; 1995 Jul 14; 23(7):702-7. PubMed ID: 7587957
    [Abstract] [Full Text] [Related]

  • 18. Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11.
    Biagini CP, Philpot RM, Célier CM.
    Arch Biochem Biophys; 1999 Jan 15; 361(2):309-14. PubMed ID: 9882461
    [Abstract] [Full Text] [Related]

  • 19. A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2.
    Chen CD, Doray B, Kemper B.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):233-8. PubMed ID: 9473296
    [Abstract] [Full Text] [Related]

  • 20. Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
    Domanski TL, He YA, Khan KK, Roussel F, Wang Q, Halpert JR.
    Biochemistry; 2001 Aug 28; 40(34):10150-60. PubMed ID: 11513592
    [Abstract] [Full Text] [Related]

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