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160 related items for PubMed ID: 9242692

  • 1. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.
    Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M.
    J Biol Chem; 1997 Aug 08; 272(32):20167-72. PubMed ID: 9242692
    [Abstract] [Full Text] [Related]

  • 2. Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.
    Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M.
    J Biol Chem; 1996 May 31; 271(22):13116-22. PubMed ID: 8662733
    [Abstract] [Full Text] [Related]

  • 3. Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.
    Fixman ED, Naujokas MA, Rodrigues GA, Moran MF, Park M.
    Oncogene; 1995 Jan 19; 10(2):237-49. PubMed ID: 7838524
    [Abstract] [Full Text] [Related]

  • 4. Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.
    Saucier C, Papavasiliou V, Palazzo A, Naujokas MA, Kremer R, Park M.
    Oncogene; 2002 Mar 14; 21(12):1800-11. PubMed ID: 11896612
    [Abstract] [Full Text] [Related]

  • 5. ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
    Ong SH, Dilworth S, Hauck-Schmalenberger I, Pawson T, Kiefer F.
    EMBO J; 2001 Nov 15; 20(22):6327-36. PubMed ID: 11707404
    [Abstract] [Full Text] [Related]

  • 6. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
    Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M.
    J Biol Chem; 1997 Aug 15; 272(33):20811-9. PubMed ID: 9252406
    [Abstract] [Full Text] [Related]

  • 7. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.
    Lock LS, Royal I, Naujokas MA, Park M.
    J Biol Chem; 2000 Oct 06; 275(40):31536-45. PubMed ID: 10913131
    [Abstract] [Full Text] [Related]

  • 8. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
    Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H.
    J Biol Chem; 1996 Feb 09; 271(6):3187-94. PubMed ID: 8621719
    [Abstract] [Full Text] [Related]

  • 9. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.
    Bardelli A, Longati P, Gramaglia D, Stella MC, Comoglio PM.
    Oncogene; 1997 Dec 18; 15(25):3103-11. PubMed ID: 9444958
    [Abstract] [Full Text] [Related]

  • 10. Activation of the JNK pathway is essential for transformation by the Met oncogene.
    Rodrigues GA, Park M, Schlessinger J.
    EMBO J; 1997 May 15; 16(10):2634-45. PubMed ID: 9184210
    [Abstract] [Full Text] [Related]

  • 11. Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.
    Mood K, Saucier C, Bong YS, Lee HS, Park M, Daar IO.
    Mol Biol Cell; 2006 Sep 15; 17(9):3717-28. PubMed ID: 16775003
    [Abstract] [Full Text] [Related]

  • 12. Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.
    Holgado-Madruga M, Wong AJ.
    Cancer Res; 2004 Mar 15; 64(6):2007-15. PubMed ID: 15026337
    [Abstract] [Full Text] [Related]

  • 13. Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase.
    Jain SK, Langdon WY, Varticovski L.
    Oncogene; 1997 May 08; 14(18):2217-28. PubMed ID: 9174058
    [Abstract] [Full Text] [Related]

  • 14. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
    Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.
    J Cell Biol; 2000 Jun 26; 149(7):1419-32. PubMed ID: 10871282
    [Abstract] [Full Text] [Related]

  • 15. Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase.
    Fournier TM, Kamikura D, Teng K, Park M.
    J Biol Chem; 1996 Sep 06; 271(36):22211-7. PubMed ID: 8703035
    [Abstract] [Full Text] [Related]

  • 16. Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.
    Lock LS, Frigault MM, Saucier C, Park M.
    J Biol Chem; 2003 Aug 08; 278(32):30083-90. PubMed ID: 12766170
    [Abstract] [Full Text] [Related]

  • 17. Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET.
    Vigna E, Gramaglia D, Longati P, Bardelli A, Comoglio PM.
    Oncogene; 1999 Jul 22; 18(29):4275-81. PubMed ID: 10435641
    [Abstract] [Full Text] [Related]

  • 18. Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.
    Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL.
    J Leukoc Biol; 1999 Apr 22; 65(4):523-34. PubMed ID: 10204582
    [Abstract] [Full Text] [Related]

  • 19. Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase.
    Anderson SM, Burton EA, Koch BL.
    J Biol Chem; 1997 Jan 10; 272(2):739-45. PubMed ID: 8995358
    [Abstract] [Full Text] [Related]

  • 20. Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.
    Meyer S, LaBudda K, McGlade J, Hayman MJ.
    Mol Cell Biol; 1994 May 10; 14(5):3253-62. PubMed ID: 7909355
    [Abstract] [Full Text] [Related]

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