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370 related items for PubMed ID: 9250416

  • 1. Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A).
    Iyer RA, Anders MW.
    Chem Res Toxicol; 1997 Jul; 10(7):811-9. PubMed ID: 9250416
    [Abstract] [Full Text] [Related]

  • 2. Nephrotoxicity of the glutathione and cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3, 3-pentafluoro-1-propene (Compound A) in male Fischer 344 rats.
    Iyer RA, Baggs RB, Anders MW.
    J Pharmacol Exp Ther; 1997 Dec; 283(3):1544-51. PubMed ID: 9400032
    [Abstract] [Full Text] [Related]

  • 3. Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
    Spracklin DK, Kharasch ED.
    Chem Res Toxicol; 1996 Jun; 9(4):696-702. PubMed ID: 8831812
    [Abstract] [Full Text] [Related]

  • 4. Cysteine conjugate beta-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A.
    Iyer RA, Frink EJ, Ebert TJ, Anders MW.
    Anesthesiology; 1998 Mar; 88(3):611-8. PubMed ID: 9523802
    [Abstract] [Full Text] [Related]

  • 5. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
    Kharasch ED, Jubert C, Spracklin DK, Hoffman GM.
    Toxicol Appl Pharmacol; 1999 Oct 01; 160(1):49-59. PubMed ID: 10502502
    [Abstract] [Full Text] [Related]

  • 6. Cysteine conjugate beta-lyase-catalyzed bioactivation of bromine-containing cysteine S-conjugates: stoichiometry and formation of 2,2-difluoro-3-halothiiranes.
    Finkelstein MB, Dekant W, Anders MW.
    Chem Res Toxicol; 1996 Oct 01; 9(1):227-31. PubMed ID: 8924595
    [Abstract] [Full Text] [Related]

  • 7. Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria.
    Iyer RA, Anders MW.
    Anesthesiology; 1996 Dec 01; 85(6):1454-61. PubMed ID: 8968194
    [Abstract] [Full Text] [Related]

  • 8. Reactive intermediate formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived cysteine S-conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems.
    Tong Z, Anders MW.
    Chem Res Toxicol; 2002 May 01; 15(5):623-8. PubMed ID: 12018982
    [Abstract] [Full Text] [Related]

  • 9.
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  • 10. Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
    Sheffels P, Schroeder JL, Altuntas TG, Liggitt HD, Kharasch ED.
    Chem Res Toxicol; 2004 Sep 01; 17(9):1177-89. PubMed ID: 15377151
    [Abstract] [Full Text] [Related]

  • 11. Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
    Gul Altuntas T, Kharasch ED.
    Drug Metab Dispos; 2002 Feb 01; 30(2):148-54. PubMed ID: 11792683
    [Abstract] [Full Text] [Related]

  • 12. Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats.
    Uttamsingh V, Iyer RA, Baggs RB, Anders MW.
    Anesthesiology; 1998 Nov 01; 89(5):1174-83. PubMed ID: 9822006
    [Abstract] [Full Text] [Related]

  • 13. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA.
    Chem Res Toxicol; 1996 Mar 01; 9(2):555-61. PubMed ID: 8839062
    [Abstract] [Full Text] [Related]

  • 14. Bioactivation of the cysteine-S-conjugate and mercapturic acid of tetrafluoroethylene to acylating reactive intermediates in the rat: dependence of activation and deactivation activities on acetyl coenzyme A availability.
    Commandeur JN, De Kanter FJ, Vermeulen NP.
    Mol Pharmacol; 1989 Oct 01; 36(4):654-63. PubMed ID: 2811861
    [Abstract] [Full Text] [Related]

  • 15. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
    Altuntas TG, Park SB, Kharasch ED.
    Chem Res Toxicol; 2004 Mar 01; 17(3):435-45. PubMed ID: 15025515
    [Abstract] [Full Text] [Related]

  • 16. Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.
    Kharasch ED, Thorning D, Garton K, Hankins DC, Kilty CG.
    Anesthesiology; 1997 Jan 01; 86(1):160-71. PubMed ID: 9009951
    [Abstract] [Full Text] [Related]

  • 17. Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
    Altuntas TG, Kharasch ED.
    Toxicol Appl Pharmacol; 2001 Dec 01; 177(2):85-93. PubMed ID: 11740907
    [Abstract] [Full Text] [Related]

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  • 19. Aminotransferase, L-amino acid oxidase and beta-lyase reactions involving L-cysteine S-conjugates found in allium extracts. Relevance to biological activity?
    Cooper AJ, Pinto JT.
    Biochem Pharmacol; 2005 Jan 15; 69(2):209-20. PubMed ID: 15627473
    [Abstract] [Full Text] [Related]

  • 20. Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
    Elfarra AA, Lash LH, Anders MW.
    Mol Pharmacol; 1987 Feb 15; 31(2):208-12. PubMed ID: 3807895
    [Abstract] [Full Text] [Related]

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