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Journal Abstract Search

110 related items for PubMed ID: 9258349

  • 1. An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.
    Smith AB, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA.
    J Med Chem; 1997 Aug 01; 40(16):2440-4. PubMed ID: 9258349
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  • 3. Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency.
    Han Q, Chang CH, Li R, Ru Y, Jadhav PK, Lam PY.
    J Med Chem; 1998 Jun 04; 41(12):2019-28. PubMed ID: 9622543
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  • 4. Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations.
    Lepsík M, Kríz Z, Havlas Z.
    Proteins; 2004 Nov 01; 57(2):279-93. PubMed ID: 15340915
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  • 5. Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
    Lu Z, Bohn J, Rano T, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5311-4. PubMed ID: 16203148
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  • 6. Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.
    Brynda J, Rezácová P, Fábry M, Horejsí M, Stouracová R, Soucek M, Hradílek M, Konvalinka J, Sedlácek J.
    Acta Crystallogr D Biol Crystallogr; 2004 Nov 01; 60(Pt 11):1943-8. PubMed ID: 15502300
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  • 9. Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
    Jadhav PK, Woerner FJ, Lam PY, Hodge CN, Eyermann CJ, Man HW, Daneker WF, Bacheler LT, Rayner MM, Meek JL, Erickson-Viitanen S, Jackson DA, Calabrese JC, Schadt M, Chang CH.
    J Med Chem; 1998 Apr 23; 41(9):1446-55. PubMed ID: 9554878
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  • 10. Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.
    Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1869-73. PubMed ID: 16480871
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  • 14. Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability.
    Fässler A, Bold G, Capraro HG, Cozens R, Mestan J, Poncioni B, Rösel J, Tintelnot-Blomley M, Lang M.
    J Med Chem; 1996 Aug 02; 39(16):3203-16. PubMed ID: 8759643
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  • 15. X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
    Ringhofer S, Kallen J, Dutzler R, Billich A, Visser AJ, Scholz D, Steinhauser O, Schreiber H, Auer M, Kungl AJ.
    J Mol Biol; 1999 Mar 05; 286(4):1147-59. PubMed ID: 10047488
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  • 17. Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors.
    Böttcher J, Blum A, Dörr S, Heine A, Diederich WE, Klebe G.
    ChemMedChem; 2008 Sep 05; 3(9):1337-44. PubMed ID: 18720485
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