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Journal Abstract Search
110 related items for PubMed ID: 9258349
1. An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. Smith AB, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA. J Med Chem; 1997 Aug 01; 40(16):2440-4. PubMed ID: 9258349 [No Abstract] [Full Text] [Related]
3. Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency. Han Q, Chang CH, Li R, Ru Y, Jadhav PK, Lam PY. J Med Chem; 1998 Jun 04; 41(12):2019-28. PubMed ID: 9622543 [Abstract] [Full Text] [Related]
4. Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations. Lepsík M, Kríz Z, Havlas Z. Proteins; 2004 Nov 01; 57(2):279-93. PubMed ID: 15340915 [Abstract] [Full Text] [Related]
5. Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus. Lu Z, Bohn J, Rano T, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5311-4. PubMed ID: 16203148 [Abstract] [Full Text] [Related]
6. Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex. Brynda J, Rezácová P, Fábry M, Horejsí M, Stouracová R, Soucek M, Hradílek M, Konvalinka J, Sedlácek J. Acta Crystallogr D Biol Crystallogr; 2004 Nov 01; 60(Pt 11):1943-8. PubMed ID: 15502300 [Abstract] [Full Text] [Related]
14. Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability. Fässler A, Bold G, Capraro HG, Cozens R, Mestan J, Poncioni B, Rösel J, Tintelnot-Blomley M, Lang M. J Med Chem; 1996 Aug 02; 39(16):3203-16. PubMed ID: 8759643 [Abstract] [Full Text] [Related]
15. X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations. Ringhofer S, Kallen J, Dutzler R, Billich A, Visser AJ, Scholz D, Steinhauser O, Schreiber H, Auer M, Kungl AJ. J Mol Biol; 1999 Mar 05; 286(4):1147-59. PubMed ID: 10047488 [Abstract] [Full Text] [Related]