These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

322 related items for PubMed ID: 9270005

  • 1. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS, Kupfer D.
    Cancer Res; 1997 Aug 15; 57(16):3402-6. PubMed ID: 9270005
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation.
    Mani C, Gelboin HV, Park SS, Pearce R, Parkinson A, Kupfer D.
    Drug Metab Dispos; 1993 Aug 15; 21(4):645-56. PubMed ID: 8104124
    [Abstract] [Full Text] [Related]

  • 3. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H, Guo Z, Persmark M, Mimura M, Inoue K, Guengerich FP, Shimada T.
    Mol Pharmacol; 1994 Sep 15; 46(3):568-77. PubMed ID: 7935340
    [Abstract] [Full Text] [Related]

  • 4. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
    Yamazaki H, Shaw PM, Guengerich FP, Shimada T.
    Chem Res Toxicol; 1998 Jun 15; 11(6):659-65. PubMed ID: 9625734
    [Abstract] [Full Text] [Related]

  • 5. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.
    Koyama E, Chiba K, Tani M, Ishizaki T.
    J Pharmacol Exp Ther; 1996 Jul 15; 278(1):21-30. PubMed ID: 8764331
    [Abstract] [Full Text] [Related]

  • 6. Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.
    Dehal SS, Kupfer D.
    Drug Metab Dispos; 1999 Jun 15; 27(6):681-8. PubMed ID: 10348797
    [Abstract] [Full Text] [Related]

  • 7. Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs.
    Koyama E, Chiba K, Tani M, Ishizaki T.
    J Pharmacol Exp Ther; 1997 Jun 15; 281(3):1199-210. PubMed ID: 9190854
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening.
    Onderwater RC, Venhorst J, Commandeur JN, Vermeulen NP.
    Chem Res Toxicol; 1999 Jul 15; 12(7):555-9. PubMed ID: 10409393
    [Abstract] [Full Text] [Related]

  • 9. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.
    Drug Metab Dispos; 2007 Jul 15; 35(7):1042-9. PubMed ID: 17403915
    [Abstract] [Full Text] [Related]

  • 10. Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.
    Raghavan N, Zhang D, Zhu M, Zeng J, Christopher L.
    Drug Metab Dispos; 2005 Feb 15; 33(2):203-8. PubMed ID: 15507542
    [Abstract] [Full Text] [Related]

  • 11. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
    Yang TJ, Krausz KW, Sai Y, Gonzalez FJ, Gelboin HV.
    Drug Metab Dispos; 1999 Jan 15; 27(1):102-9. PubMed ID: 9884317
    [Abstract] [Full Text] [Related]

  • 12. Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin.
    Parte P, Kupfer D.
    Drug Metab Dispos; 2005 Oct 15; 33(10):1446-52. PubMed ID: 15987777
    [Abstract] [Full Text] [Related]

  • 13. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.
    Arch Biochem Biophys; 1996 Sep 01; 333(1):127-38. PubMed ID: 8806763
    [Abstract] [Full Text] [Related]

  • 14. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.
    Crewe HK, Ellis SW, Lennard MS, Tucker GT.
    Biochem Pharmacol; 1997 Jan 24; 53(2):171-8. PubMed ID: 9037249
    [Abstract] [Full Text] [Related]

  • 15. The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
    Dehal SS, Brodie AM, Kupfer D.
    Drug Metab Dispos; 1999 Mar 24; 27(3):389-94. PubMed ID: 10064571
    [Abstract] [Full Text] [Related]

  • 16. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.
    Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM.
    Drug Metab Dispos; 2002 Aug 24; 30(8):869-74. PubMed ID: 12124303
    [Abstract] [Full Text] [Related]

  • 17. Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
    Teiber JF, Hollenberg PF.
    Carcinogenesis; 2000 Aug 24; 21(8):1559-66. PubMed ID: 10910959
    [Abstract] [Full Text] [Related]

  • 18. Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
    Dehal SS, Kupfer D.
    Cancer Res; 1996 Mar 15; 56(6):1283-90. PubMed ID: 8640815
    [Abstract] [Full Text] [Related]

  • 19. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
    Coleman T, Ellis SW, Martin IJ, Lennard MS, Tucker GT.
    J Pharmacol Exp Ther; 1996 May 15; 277(2):685-90. PubMed ID: 8627546
    [Abstract] [Full Text] [Related]

  • 20. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T, Guillén H, Arán VJ, Idle JR, Gonzalez FJ.
    Toxicol Appl Pharmacol; 2006 Nov 01; 216(3):387-98. PubMed ID: 16870220
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 17.