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Journal Abstract Search

373 related items for PubMed ID: 9280396

  • 1. Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.
    Carlile DJ, Zomorodi K, Houston JB.
    Drug Metab Dispos; 1997 Aug; 25(8):903-11. PubMed ID: 9280396
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  • 2. Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition.
    Worboys PD, Brennan B, Bradbury A, Houston JB.
    Xenobiotica; 1996 Sep; 26(9):897-907. PubMed ID: 8893037
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  • 6. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y, Terashita S, Kimura S, Suzuki A, Kagayama A, Sugiyama Y.
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
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  • 8. Determination of microsome and hepatocyte scaling factors for in vitro/in vivo extrapolation in the rat and dog.
    Smith R, Jones RD, Ballard PG, Griffiths HH.
    Xenobiotica; 2008 Nov; 38(11):1386-98. PubMed ID: 18988082
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  • 9. Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
    Reilly PE, Thompson DA, Mason SR, Hooper WD.
    Mol Pharmacol; 1990 May; 37(5):767-74. PubMed ID: 1971091
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  • 11. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM, Houston JB.
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
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  • 12. In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes.
    Carlile DJ, Stevens AJ, Ashforth EI, Waghela D, Houston JB.
    Drug Metab Dispos; 1998 Mar; 26(3):216-21. PubMed ID: 9492383
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  • 13. Cytochrome P4503A is the major source of N-vinylprotoporphyrin IX formation after administration of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone to untreated and dexamethasone-pretreated rats.
    McNamee JP, Marks GS.
    Drug Metab Dispos; 1996 Aug; 24(8):872-8. PubMed ID: 8869822
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  • 14. Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
    Brown HS, Wilby AJ, Alder J, Houston JB.
    Drug Metab Dispos; 2010 Dec; 38(12):2139-46. PubMed ID: 20847136
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  • 17. Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
    Jones HM, Hallifax D, Houston JB.
    Drug Metab Dispos; 2004 May; 32(5):572-80. PubMed ID: 15100181
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  • 20. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
    Kuperman AV, Kalgutkar AS, Marfat A, Chambers RJ, Liston TE.
    Drug Metab Dispos; 2001 Nov; 29(11):1403-9. PubMed ID: 11602515
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