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Journal Abstract Search

185 related items for PubMed ID: 9288166

  • 1. Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.
    Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA.
    J Med Chem; 1997 Aug 29; 40(18):2843-57. PubMed ID: 9288166
    [Abstract] [Full Text] [Related]

  • 2. GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
    Hayashi Y, Katada J, Harada T, Tachiki A, Iijima K, Takiguchi Y, Muramatsu M, Miyazaki H, Asari T, Okazaki T, Sato Y, Yasuda E, Yano M, Uno I, Ojima I.
    J Med Chem; 1998 Jun 18; 41(13):2345-60. PubMed ID: 9632368
    [Abstract] [Full Text] [Related]

  • 3. New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: orally active series of N-alkylated amidines with a 6,6-bicyclic template.
    Okumura K, Shimazaki T, Aoki Y, Yamashita H, Tanaka E, Banba S, Yazawa K, Kibayashi K, Banno H.
    J Med Chem; 1998 Oct 08; 41(21):4036-52. PubMed ID: 9767641
    [Abstract] [Full Text] [Related]

  • 4. Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.
    Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM.
    J Med Chem; 1997 Dec 19; 40(26):4308-18. PubMed ID: 9435900
    [Abstract] [Full Text] [Related]

  • 5. Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists.
    Robarge KD, Dina MS, Somers TC, Lee A, Rawson TE, Olivero AG, Tischler MH, Webb RR, Weese KJ, Aliagas I, Blackburn BK.
    Bioorg Med Chem; 1998 Dec 19; 6(12):2345-81. PubMed ID: 9925295
    [Abstract] [Full Text] [Related]

  • 6. Glycoprotein IIb/IIIa receptor number and occupancy during chronic administration of an oral antagonist.
    Quinn MJ, Cox D, Foley JB, Fitzgerald DJ.
    J Pharmacol Exp Ther; 2000 Nov 19; 295(2):670-6. PubMed ID: 11046104
    [Abstract] [Full Text] [Related]

  • 7. Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists.
    Malovichko OL, Petrus AS, Krysko AA, Kabanova TA, Andronati SA, Karaseva TL, Kiriyak AV.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5294-7. PubMed ID: 16919941
    [Abstract] [Full Text] [Related]

  • 8. New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent.
    Badorc A, Bordes MF, de Cointet P, Savi P, Bernat A, Lalé A, Petitou M, Maffrand JP, Herbert JM.
    J Med Chem; 1997 Oct 10; 40(21):3393-401. PubMed ID: 9341914
    [Abstract] [Full Text] [Related]

  • 9. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 1: design and synthesis of a lead compound exhibiting alpha(v)beta3/alpha(IIb)beta3 dual antagonistic activity.
    Kubota D, Ishikawa M, Yamamoto M, Murakami S, Hachisu M, Katano K, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2089-108. PubMed ID: 16309911
    [Abstract] [Full Text] [Related]

  • 10. Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.
    Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD.
    J Med Chem; 1997 Jun 06; 40(12):1779-88. PubMed ID: 9191954
    [Abstract] [Full Text] [Related]

  • 11. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part III: synthesis of potent antagonists with alpha(v)beta3/alpha(IIb)beta3 dual activity and improved water solubility.
    Ishikawa M, Hiraiwa Y, Kubota D, Tsushima M, Watanabe T, Murakami S, Ouchi S, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2131-50. PubMed ID: 16307881
    [Abstract] [Full Text] [Related]

  • 12. Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.
    Keenan RM, Callahan JF, Samanen JM, Bondinell WE, Calvo RR, Chen L, DeBrosse C, Eggleston DS, Haltiwanger RC, Hwang SM, Jakas DR, Ku TW, Miller WH, Newlander KA, Nichols A, Parker MF, Southhall LS, Uzinskas I, Vasko-Moser JA, Venslavsky JW, Wong AS, Huffman WF.
    J Med Chem; 1999 Feb 25; 42(4):545-59. PubMed ID: 10052962
    [Abstract] [Full Text] [Related]

  • 13. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 2: synthesis of potent alpha(v)beta3/alpha(IIb)beta3 dual antagonists.
    Ishikawa M, Kubota D, Yamamoto M, Kuroda C, Iguchi M, Koyanagi A, Murakami S, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2109-30. PubMed ID: 16309912
    [Abstract] [Full Text] [Related]

  • 14. Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
    Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA.
    Bioorg Med Chem Lett; 2000 Feb 21; 10(4):385-9. PubMed ID: 10714506
    [Abstract] [Full Text] [Related]

  • 15. Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
    Hutchinson JH, Cook JJ, Brashear KM, Breslin MJ, Glass JD, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Sitko GR, Stranieri MT, Hartman GD.
    J Med Chem; 1996 Nov 08; 39(23):4583-91. PubMed ID: 8917647
    [Abstract] [Full Text] [Related]

  • 16. From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus.
    Blackburn BK, Lee A, Baier M, Kohl B, Olivero AG, Matamoros R, Robarge KD, McDowell RS.
    J Med Chem; 1997 Feb 28; 40(5):717-29. PubMed ID: 9057858
    [Abstract] [Full Text] [Related]

  • 17. A whole blood assay of inhibition of platelet aggregation by glycoprotein IIb/IIIa antagonists: comparison with other aggregation methodologies.
    Storey RF, May JA, Wilcox RG, Heptinstall S.
    Thromb Haemost; 1999 Oct 28; 82(4):1307-11. PubMed ID: 10544919
    [Abstract] [Full Text] [Related]

  • 18. Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study.
    Anderluh M, Cesar J, Stefanic P, Kikelj D, Janes D, Murn J, Nadrah K, Tominc M, Addicks E, Giannis A, Stegnar M, Dolenc MS.
    Eur J Med Chem; 2005 Jan 28; 40(1):25-49. PubMed ID: 15642407
    [Abstract] [Full Text] [Related]

  • 19. The anti-platelet approach targeting the fibrinogen ligand of the GPIIB/IIIa receptor.
    Tsikaris V.
    J Pept Sci; 2004 Oct 28; 10(10):589-602. PubMed ID: 15526708
    [Abstract] [Full Text] [Related]

  • 20. [GP IIb/IIIa receptor antagonists--molecular and clinical aspects].
    Francuz T.
    Postepy Hig Med Dosw; 2001 Oct 28; 55(3):419-32. PubMed ID: 11505641
    [Abstract] [Full Text] [Related]

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