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198 related items for PubMed ID: 9348219

  • 1. Beta-cell lines derived from transgenic Cpe(fat)/Cpe(fat) mice are defective in carboxypeptidase E and proinsulin processing.
    Varlamov O, Fricker LD, Furukawa H, Steiner DF, Langley SH, Leiter EH.
    Endocrinology; 1997 Nov; 138(11):4883-92. PubMed ID: 9348219
    [Abstract] [Full Text] [Related]

  • 2. Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.
    Cawley NX, Rodriguez YM, Maldonado A, Loh YP.
    Endocrinology; 2003 Jan; 144(1):292-8. PubMed ID: 12488357
    [Abstract] [Full Text] [Related]

  • 3. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
    Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH.
    Nat Genet; 1995 Jun; 10(2):135-42. PubMed ID: 7663508
    [Abstract] [Full Text] [Related]

  • 4. Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient Cpefat/Cpefat mice.
    Irminger JC, Verchere CB, Meyer K, Halban PA.
    J Biol Chem; 1997 Oct 31; 272(44):27532-4. PubMed ID: 9346885
    [Abstract] [Full Text] [Related]

  • 5. Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.
    Normant E, Loh YP.
    Endocrinology; 1998 Apr 31; 139(4):2137-45. PubMed ID: 9529003
    [Abstract] [Full Text] [Related]

  • 6. Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.
    Marzban L, Soukhatcheva G, Verchere CB.
    Endocrinology; 2005 Apr 31; 146(4):1808-17. PubMed ID: 15618358
    [Abstract] [Full Text] [Related]

  • 7. Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice.
    Chen YC, Taylor AJ, Fulcher JM, Swensen AC, Dai XQ, Komba M, Wrightson KLC, Fok K, Patterson AE, Klein Geltink RI, MacDonald PE, Qian WJ, Verchere CB.
    Diabetes; 2023 Sep 01; 72(9):1277-1288. PubMed ID: 37364047
    [Abstract] [Full Text] [Related]

  • 8. Effects of carboxypeptidase E overexpression on insulin mRNA levels, regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA.
    Polastri L, Galbiati F, Folli F, Davalli AM.
    Cell Transplant; 2002 Sep 01; 11(8):803-11. PubMed ID: 12588113
    [Abstract] [Full Text] [Related]

  • 9. Proinsulin cleaved by furin is processed to chromatographically mature insulin by carboxypeptidases in nonneuroendocrine cells.
    Nishigori T, Yanagita M, Takeuchi T.
    Peptides; 1996 Sep 01; 17(5):789-96. PubMed ID: 8844768
    [Abstract] [Full Text] [Related]

  • 10. Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.
    Chu KY, Briggs MJ, Albrecht T, Drain PF, Johnson JD.
    Islets; 2011 Sep 01; 3(4):155-65. PubMed ID: 21628999
    [Abstract] [Full Text] [Related]

  • 11. Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice.
    Rovere C, Viale A, Nahon J, Kitabgi P.
    Endocrinology; 1996 Jul 01; 137(7):2954-8. PubMed ID: 8770919
    [Abstract] [Full Text] [Related]

  • 12. Induced and spontaneous mutations at Ser202 of carboxypeptidase E. Effect on enzyme expression, activity, and intracellular routing.
    Varlamov O, Leiter EH, Fricker L.
    J Biol Chem; 1996 Jun 14; 271(24):13981-6. PubMed ID: 8662840
    [Abstract] [Full Text] [Related]

  • 13. Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor.
    Zhang CF, Snell CR, Loh YP.
    Mol Endocrinol; 1999 Apr 14; 13(4):527-36. PubMed ID: 10194759
    [Abstract] [Full Text] [Related]

  • 14. Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus.
    Leiter EH, Kintner J, Flurkey K, Beamer WG, Naggert JK.
    Endocrine; 1999 Feb 14; 10(1):57-66. PubMed ID: 10403572
    [Abstract] [Full Text] [Related]

  • 15. The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans.
    Guest PC, Arden SD, Rutherford NG, Hutton JC.
    Mol Cell Endocrinol; 1995 Aug 30; 113(1):99-108. PubMed ID: 8674818
    [Abstract] [Full Text] [Related]

  • 16. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
    Alarcón C, Leahy JL, Schuppin GT, Rhodes CJ.
    J Clin Invest; 1995 Mar 30; 95(3):1032-9. PubMed ID: 7883951
    [Abstract] [Full Text] [Related]

  • 17. Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.
    Fricker LD, Berman YL, Leiter EH, Devi LA.
    J Biol Chem; 1996 Nov 29; 271(48):30619-24. PubMed ID: 8940036
    [Abstract] [Full Text] [Related]

  • 18. Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
    Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF.
    J Biol Chem; 1998 Feb 06; 273(6):3431-7. PubMed ID: 9452465
    [Abstract] [Full Text] [Related]

  • 19. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.
    Utsunomiya N, Ohagi S, Sanke T, Tatsuta H, Hanabusa T, Nanjo K.
    Diabetologia; 1998 Jun 06; 41(6):701-5. PubMed ID: 9662053
    [Abstract] [Full Text] [Related]

  • 20. Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E.
    Boudarine M, Yegorov O, Sterling-Dubrovsky A, Devi LA, Berman Y.
    J Pharmacol Exp Ther; 2002 Dec 06; 303(3):1317-24. PubMed ID: 12438557
    [Abstract] [Full Text] [Related]

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