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208 related items for PubMed ID: 9353300

  • 1. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
    Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS.
    J Biol Chem; 1997 Nov 07; 272(45):28415-22. PubMed ID: 9353300
    [Abstract] [Full Text] [Related]

  • 2. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
    Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G.
    J Biol Chem; 1999 May 14; 274(20):13818-23. PubMed ID: 10318786
    [Abstract] [Full Text] [Related]

  • 3. Stable association of presenilin derivatives and absence of presenilin interactions with APP.
    Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS.
    Neurobiol Dis; 1998 Apr 14; 4(6):438-53. PubMed ID: 9666482
    [Abstract] [Full Text] [Related]

  • 4. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
    Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, Fraser PE, Andreadis A, Nixon RA.
    Mol Med; 2000 Oct 14; 6(10):878-91. PubMed ID: 11126202
    [Abstract] [Full Text] [Related]

  • 5. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
    Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS.
    J Neurosci; 1996 Dec 01; 16(23):7513-25. PubMed ID: 8922407
    [Abstract] [Full Text] [Related]

  • 6. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
    Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.
    Biochemistry; 2001 Jul 27; 40(28):8359-68. PubMed ID: 11444983
    [Abstract] [Full Text] [Related]

  • 7. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
    Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS.
    Neuron; 1996 Jul 27; 17(1):181-90. PubMed ID: 8755489
    [Abstract] [Full Text] [Related]

  • 8. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
    Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS.
    Nat Med; 1997 Jul 27; 3(7):756-60. PubMed ID: 9212102
    [Abstract] [Full Text] [Related]

  • 9. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.
    Alves da Costa C, Paitel E, Mattson MP, Amson R, Telerman A, Ancolio K, Checler F.
    Proc Natl Acad Sci U S A; 2002 Mar 19; 99(6):4043-8. PubMed ID: 11904448
    [Abstract] [Full Text] [Related]

  • 10. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D.
    Proc Natl Acad Sci U S A; 2005 Jun 21; 102(25):8972-7. PubMed ID: 15951428
    [Abstract] [Full Text] [Related]

  • 11. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
    da Costa CA, Ancolio K, Checler F.
    Mol Med; 1999 Mar 21; 5(3):160-8. PubMed ID: 10404513
    [Abstract] [Full Text] [Related]

  • 12. Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.
    Culvenor JG, Evin G, Cooney MA, Wardan H, Sharples RA, Maher F, Reed G, Diehlmann A, Weidemann A, Beyreuther K, Masters CL.
    Exp Cell Res; 2000 Mar 15; 255(2):192-206. PubMed ID: 10694435
    [Abstract] [Full Text] [Related]

  • 13. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
    Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE.
    Mol Med; 1999 Aug 15; 5(8):542-54. PubMed ID: 10501657
    [Abstract] [Full Text] [Related]

  • 14. Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.
    Shirotani K, Takahashi K, Araki W, Maruyama K, Tabira T.
    J Biol Chem; 2000 Feb 04; 275(5):3681-6. PubMed ID: 10652366
    [Abstract] [Full Text] [Related]

  • 15. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
    Tanii H, Ankarcrona M, Flood F, Nilsberth C, Mehta ND, Perez-Tur J, Winblad B, Benedikz E, Cowburn RF.
    Neuroscience; 2000 Feb 04; 95(2):593-601. PubMed ID: 10658639
    [Abstract] [Full Text] [Related]

  • 16. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
    Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G.
    Nat Cell Biol; 2000 Dec 04; 2(12):863-70. PubMed ID: 11146649
    [Abstract] [Full Text] [Related]

  • 17. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
    Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ.
    J Biol Chem; 1997 Mar 21; 272(12):7977-82. PubMed ID: 9065468
    [Abstract] [Full Text] [Related]

  • 18. Presenilins are processed by caspase-type proteases.
    Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grünberg J, Haass C, Jacobsen H.
    J Biol Chem; 1997 Aug 15; 272(33):20655-9. PubMed ID: 9252383
    [Abstract] [Full Text] [Related]

  • 19. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ.
    J Biol Chem; 2000 Feb 04; 275(5):3173-8. PubMed ID: 10652302
    [Abstract] [Full Text] [Related]

  • 20. Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines.
    Shirotani K, Takahashi K, Ozawa K, Kunishita T, Tabira T.
    Biochem Biophys Res Commun; 1997 Nov 26; 240(3):728-31. PubMed ID: 9398634
    [Abstract] [Full Text] [Related]

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