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Journal Abstract Search

189 related items for PubMed ID: 9354617

  • 21. Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis.
    Cheng Y, Slon-Usakiewicz JJ, Wang J, Purisima EO, Konishi Y.
    Biochemistry; 1996 Oct 08; 35(40):13021-9. PubMed ID: 8855937
    [Abstract] [Full Text] [Related]

  • 22. Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.
    Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y.
    Biochemistry; 1994 Dec 06; 33(48):14443-51. PubMed ID: 7981204
    [Abstract] [Full Text] [Related]

  • 23. Conformational analysis of gamma' peptide (410-427) interactions with thrombin anion binding exosite II.
    Sabo TM, Farrell DH, Maurer MC.
    Biochemistry; 2006 Jun 20; 45(24):7434-45. PubMed ID: 16768439
    [Abstract] [Full Text] [Related]

  • 24. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 25. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.
    J Mol Biol; 2009 Aug 21; 391(3):552-64. PubMed ID: 19520086
    [Abstract] [Full Text] [Related]

  • 26. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 21; 5(6):1174-83. PubMed ID: 8762149
    [Abstract] [Full Text] [Related]

  • 27. Structure-function relationship of serine protease-protein inhibitor interaction.
    Otlewski J, Jaskólski M, Buczek O, Cierpicki T, Czapińska H, Krowarsch D, Smalas AO, Stachowiak D, Szpineta A, Dadlez M.
    Acta Biochim Pol; 2001 Jun 21; 48(2):419-28. PubMed ID: 11732612
    [Abstract] [Full Text] [Related]

  • 28. NMR determination of pKa values for Asp, Glu, His, and Lys mutants at each variable contiguous enzyme-inhibitor contact position of the turkey ovomucoid third domain.
    Song J, Laskowski M, Qasim MA, Markley JL.
    Biochemistry; 2003 Mar 18; 42(10):2847-56. PubMed ID: 12627950
    [Abstract] [Full Text] [Related]

  • 29. A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
    Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F.
    Angew Chem Int Ed Engl; 2003 Jun 06; 42(22):2507-11. PubMed ID: 12800172
    [No Abstract] [Full Text] [Related]

  • 30. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.
    Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.
    Biochemistry; 1999 Jun 22; 38(25):7969-77. PubMed ID: 10387040
    [Abstract] [Full Text] [Related]

  • 31. Exploring inhibitor binding at the S' subsites of cathepsin L.
    Chowdhury SF, Joseph L, Kumar S, Tulsidas SR, Bhat S, Ziomek E, Ménard R, Sivaraman J, Purisima EO.
    J Med Chem; 2008 Mar 13; 51(5):1361-8. PubMed ID: 18278855
    [Abstract] [Full Text] [Related]

  • 32. The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.
    Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1999 Jan 13; 8(1):91-5. PubMed ID: 10210187
    [Abstract] [Full Text] [Related]

  • 33. Predicted three-dimensional structural models of venom serine protease inhibitors and their interactions with trypsin and chymotrypsin.
    Azim MK, Grossmann JG, Zaidi ZH.
    J Nat Toxins; 1999 Oct 13; 8(3):363-84. PubMed ID: 10591040
    [Abstract] [Full Text] [Related]

  • 34. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
    Sperl S, Bergner A, Stürzebecher J, Magdolen V, Bode W, Moroder L.
    Biol Chem; 2000 Apr 13; 381(4):321-9. PubMed ID: 10839461
    [Abstract] [Full Text] [Related]

  • 35. The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.
    Grembecka J, Mucha A, Cierpicki T, Kafarski P.
    J Med Chem; 2003 Jun 19; 46(13):2641-55. PubMed ID: 12801228
    [Abstract] [Full Text] [Related]

  • 36. Compounds binding to the S2-S3 pockets of thrombin.
    Nilsson M, Hämäläinen M, Ivarsson M, Gottfries J, Xue Y, Hansson S, Isaksson R, Fex T.
    J Med Chem; 2009 May 14; 52(9):2708-15. PubMed ID: 19371038
    [Abstract] [Full Text] [Related]

  • 37. Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition.
    Fodor K, Harmat V, Hetényi C, Kardos J, Antal J, Perczel A, Patthy A, Katona G, Gráf L.
    J Mol Biol; 2005 Jul 01; 350(1):156-69. PubMed ID: 15922357
    [Abstract] [Full Text] [Related]

  • 38. Full or partial substitution of the reactive center loop of alpha-1-proteinase inhibitor by that of heparin cofactor II: P1 Arg is required for maximal thrombin inhibition.
    Filion ML, Bhakta V, Nguyen LH, Liaw PS, Sheffield WP.
    Biochemistry; 2004 Nov 23; 43(46):14864-72. PubMed ID: 15544357
    [Abstract] [Full Text] [Related]

  • 39. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW.
    Protein Sci; 2000 Jan 23; 9(1):29-36. PubMed ID: 10739244
    [Abstract] [Full Text] [Related]

  • 40. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.
    Biochemistry; 1998 Oct 13; 37(41):14420-7. PubMed ID: 9772168
    [Abstract] [Full Text] [Related]

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