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126 related items for PubMed ID: 9367823

  • 21. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase.
    Stancato LF, Silverstein AM, Owens-Grillo JK, Chow YH, Jove R, Pratt WB.
    J Biol Chem; 1997 Feb 14; 272(7):4013-20. PubMed ID: 9020108
    [Abstract] [Full Text] [Related]

  • 22. Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.
    Loo MA, Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR.
    EMBO J; 1998 Dec 01; 17(23):6879-87. PubMed ID: 9843494
    [Abstract] [Full Text] [Related]

  • 23. Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
    Mimnaugh EG, Chavany C, Neckers L.
    J Biol Chem; 1996 Sep 13; 271(37):22796-801. PubMed ID: 8798456
    [Abstract] [Full Text] [Related]

  • 24. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.
    Schulte TW, Blagosklonny MV, Ingui C, Neckers L.
    J Biol Chem; 1995 Oct 13; 270(41):24585-8. PubMed ID: 7592678
    [Abstract] [Full Text] [Related]

  • 25. Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin.
    Busconi L, Guan J, Denker BM.
    J Biol Chem; 2000 Jan 21; 275(3):1565-9. PubMed ID: 10636845
    [Abstract] [Full Text] [Related]

  • 26. Degradation signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist protection by cis glycine-alanine repeat.
    Piechocki MP, Pilon SA, Kelly C, Wei WZ.
    Cell Immunol; 2001 Sep 15; 212(2):138-49. PubMed ID: 11748930
    [Abstract] [Full Text] [Related]

  • 27. Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.
    Galigniana MD, Harrell JM, Housley PR, Patterson C, Fisher SK, Pratt WB.
    Brain Res Mol Brain Res; 2004 Apr 07; 123(1-2):27-36. PubMed ID: 15046863
    [Abstract] [Full Text] [Related]

  • 28. Geldanamycin provides posttreatment protection against glutamate-induced oxidative toxicity in a mouse hippocampal cell line.
    Xiao N, Callaway CW, Lipinski CA, Hicks SD, DeFranco DB.
    J Neurochem; 1999 Jan 07; 72(1):95-101. PubMed ID: 9886059
    [Abstract] [Full Text] [Related]

  • 29. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation.
    Luo J, Benovic JL.
    J Biol Chem; 2003 Dec 19; 278(51):50908-14. PubMed ID: 14557268
    [Abstract] [Full Text] [Related]

  • 30. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
    Doong H, Rizzo K, Fang S, Kulpa V, Weissman AM, Kohn EC.
    J Biol Chem; 2003 Aug 01; 278(31):28490-500. PubMed ID: 12750378
    [Abstract] [Full Text] [Related]

  • 31. Immunosuppressive effects of the heat shock protein 90-binding antibiotic geldanamycin.
    Sugita T, Tanaka S, Murakami T, Miyoshi H, Ohnuki T.
    Biochem Mol Biol Int; 1999 Apr 01; 47(4):587-95. PubMed ID: 10319410
    [Abstract] [Full Text] [Related]

  • 32. Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases.
    Sepp-Lorenzino L, Ma Z, Lebwohl DE, Vinitsky A, Rosen N.
    J Biol Chem; 1995 Jul 14; 270(28):16580-7. PubMed ID: 7622464
    [Abstract] [Full Text] [Related]

  • 33. Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.
    An WG, Schnur RC, Neckers L, Blagosklonny MV.
    Cancer Chemother Pharmacol; 1997 Jul 14; 40(1):60-4. PubMed ID: 9137531
    [Abstract] [Full Text] [Related]

  • 34. Heat shock protein 90 indirectly regulates ERK activity by affecting Raf protein metabolism.
    Dou F, Yuan LD, Zhu JJ.
    Acta Biochim Biophys Sin (Shanghai); 2005 Jul 14; 37(7):501-5. PubMed ID: 15999212
    [Abstract] [Full Text] [Related]

  • 35. Depletion of Raf-1 protooncogene by geldanamycin causes apoptosis in human luteinized granulosa cells.
    Khan SM, Oliver RH, Dauffenbach LM, Yeh J.
    Fertil Steril; 2000 Aug 14; 74(2):359-65. PubMed ID: 10927059
    [Abstract] [Full Text] [Related]

  • 36. Geldanamycin-induced degradation of Chk1 is mediated by proteasome.
    Nomura M, Nomura N, Yamashita J.
    Biochem Biophys Res Commun; 2005 Sep 30; 335(3):900-5. PubMed ID: 16099423
    [Abstract] [Full Text] [Related]

  • 37. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.
    Fisher EA, Zhou M, Mitchell DM, Wu X, Omura S, Wang H, Goldberg AL, Ginsberg HN.
    J Biol Chem; 1997 Aug 15; 272(33):20427-34. PubMed ID: 9252351
    [Abstract] [Full Text] [Related]

  • 38. Heat shock protein and proteasome targeting agents.
    Takimoto CH, Diggikar S.
    Hematol Oncol Clin North Am; 2002 Oct 15; 16(5):1269-85. PubMed ID: 12512392
    [Abstract] [Full Text] [Related]

  • 39. Heregulin beta1 induces the down regulation and the ubiquitin-proteasome degradation pathway of p185HER2 oncoprotein.
    Magnifico A, Tagliabue E, Ardini E, Casalini P, Colnaghi MI, Ménard S.
    FEBS Lett; 1998 Jan 30; 422(2):129-31. PubMed ID: 9489990
    [Abstract] [Full Text] [Related]

  • 40. Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
    Mandler R, Kobayashi H, Hinson ER, Brechbiel MW, Waldmann TA.
    Cancer Res; 2004 Feb 15; 64(4):1460-7. PubMed ID: 14973048
    [Abstract] [Full Text] [Related]

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