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293 related items for PubMed ID: 9369485

  • 1. Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
    Suresh Kumar G, Lipman R, Cummings J, Tomasz M.
    Biochemistry; 1997 Nov 18; 36(46):14128-36. PubMed ID: 9369485
    [Abstract] [Full Text] [Related]

  • 2. Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.
    Pan SS, Yu F, Hipsher C.
    Mol Pharmacol; 1993 Jun 18; 43(6):870-7. PubMed ID: 8316219
    [Abstract] [Full Text] [Related]

  • 3. Effect of pH on DNA alkylation by enzyme-activated mitomycin C and porfiromycin.
    Yu F, Pan SS.
    Mol Pharmacol; 1993 Jun 18; 43(6):863-9. PubMed ID: 8391116
    [Abstract] [Full Text] [Related]

  • 4. Reductive activation of mitomycin C by thiols: kinetics, mechanism, and biological implications.
    Paz MM.
    Chem Res Toxicol; 2009 Oct 18; 22(10):1663-8. PubMed ID: 19791750
    [Abstract] [Full Text] [Related]

  • 5. Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
    Palom Y, Belcourt MF, Kumar GS, Arai H, Kasai M, Sartorelli AC, Rockwell S, Tomasz M.
    Oncol Res; 1998 Oct 18; 10(10):509-21. PubMed ID: 10338154
    [Abstract] [Full Text] [Related]

  • 6. Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation.
    Maliepaard M, de Mol NJ, Tomasz M, Gargiulo D, Janssen LH, van Duynhoven JP, van Velzen EJ, Verboom W, Reinhoudt DN.
    Biochemistry; 1997 Jul 29; 36(30):9211-20. PubMed ID: 9230054
    [Abstract] [Full Text] [Related]

  • 7. Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.
    Beall HD, Mulcahy RT, Siegel D, Traver RD, Gibson NW, Ross D.
    Cancer Res; 1994 Jun 15; 54(12):3196-201. PubMed ID: 8205540
    [Abstract] [Full Text] [Related]

  • 8. A mitomycin-N6-deoxyadenosine adduct isolated from DNA.
    Palom Y, Lipman R, Musser SM, Tomasz M.
    Chem Res Toxicol; 1998 Mar 15; 11(3):203-10. PubMed ID: 9544618
    [Abstract] [Full Text] [Related]

  • 9. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
    Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.
    Cancer Res; 1984 Dec 15; 44(12 Pt 1):5638-43. PubMed ID: 6437671
    [Abstract] [Full Text] [Related]

  • 10. Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
    Bizanek R, Chowdary D, Arai H, Kasai M, Hughes CS, Sartorelli AC, Rockwell S, Tomasz M.
    Cancer Res; 1993 Nov 01; 53(21):5127-34. PubMed ID: 7693331
    [Abstract] [Full Text] [Related]

  • 11. DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
    Mikami K, Naito M, Tomida A, Yamada M, Sirakusa T, Tsuruo T.
    Cancer Res; 1996 Jun 15; 56(12):2823-6. PubMed ID: 8665520
    [Abstract] [Full Text] [Related]

  • 12. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.
    Begleiter A, Leith MK.
    Mol Pharmacol; 1993 Jul 15; 44(1):210-5. PubMed ID: 8341273
    [Abstract] [Full Text] [Related]

  • 13. Bioreductive activation of mitomycin C by DT-diaphorase.
    Siegel D, Beall H, Senekowitsch C, Kasai M, Arai H, Gibson NW, Ross D.
    Biochemistry; 1992 Sep 01; 31(34):7879-85. PubMed ID: 1510975
    [Abstract] [Full Text] [Related]

  • 14. Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines.
    Beall HD, Murphy AM, Siegel D, Hargreaves RH, Butler J, Ross D.
    Mol Pharmacol; 1995 Sep 01; 48(3):499-504. PubMed ID: 7565631
    [Abstract] [Full Text] [Related]

  • 15. DT-diaphorase as a target enzyme for biochemical modulation of mitomycin C.
    Saeki S, Nishiyama M, Toge T.
    Hiroshima J Med Sci; 1995 Sep 01; 44(3):55-63. PubMed ID: 8567314
    [Abstract] [Full Text] [Related]

  • 16. DNA alkylation by enzyme-activated mitomycin C.
    Pan SS, Iracki T, Bachur NR.
    Mol Pharmacol; 1986 Jun 01; 29(6):622-8. PubMed ID: 3086708
    [Abstract] [Full Text] [Related]

  • 17. Tumor-specific synergistic therapy of mitomycin C: modulation of bioreductive activation.
    Sakamoto N, Toge T, Nishiyama M.
    Hiroshima J Med Sci; 1997 Jun 01; 46(2):67-73. PubMed ID: 9232934
    [Abstract] [Full Text] [Related]

  • 18. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 01; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 19. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
    Siegel D, Gibson NW, Preusch PC, Ross D.
    Cancer Res; 1990 Dec 01; 50(23):7483-9. PubMed ID: 1701346
    [Abstract] [Full Text] [Related]

  • 20. pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
    Siegel D, Beall H, Kasai M, Arai H, Gibson NW, Ross D.
    Mol Pharmacol; 1993 Dec 01; 44(6):1128-34. PubMed ID: 8264549
    [Abstract] [Full Text] [Related]

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