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178 related items for PubMed ID: 9371357

  • 1. Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.
    Pan-Zhou XR, Cretton-Scott E, Zhou XJ, Xie MY, Rahmani R, Schinazi RF, Duchin K, Sommadossi JP.
    Antimicrob Agents Chemother; 1997 Nov; 41(11):2502-10. PubMed ID: 9371357
    [Abstract] [Full Text] [Related]

  • 2. Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus.
    Zhou XJ, Squires K, Pan-Zhou XR, Bernhard S, Agrofoglio L, Kirk M, Duchin KL, Sommadossi JP.
    J Clin Pharmacol; 1997 Mar; 37(3):201-13. PubMed ID: 9089422
    [Abstract] [Full Text] [Related]

  • 3. Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
    Cretton EM, Xie MY, Bevan RJ, Goudgaon NM, Schinazi RF, Sommadossi JP.
    Mol Pharmacol; 1991 Feb; 39(2):258-66. PubMed ID: 1996084
    [Abstract] [Full Text] [Related]

  • 4. Comparative metabolism of 3'-azido-3'-deoxythymidine in cultured hepatocytes from rats, dogs, monkeys, and humans.
    Nicolas F, De Sousa G, Thomas P, Placidi M, Lorenzon G, Rahmani R.
    Drug Metab Dispos; 1995 Mar; 23(3):308-13. PubMed ID: 7628294
    [Abstract] [Full Text] [Related]

  • 5. Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes.
    Cretton EM, Sommadossi JP.
    Biochem Pharmacol; 1991 Sep 12; 42(7):1475-80. PubMed ID: 1930271
    [Abstract] [Full Text] [Related]

  • 6. Transport properties of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in the rat choroid plexus.
    Takasawa K, Suzuki H, Sugiyama Y.
    Biopharm Drug Dispos; 1997 Oct 12; 18(7):611-22. PubMed ID: 9330781
    [Abstract] [Full Text] [Related]

  • 7. Pharmacodynamic studies (PD) of didanosine (ddI) alone and in combination with azidothymidine (AZT) in human T-cells; a stochastic biochemical approach to antiretroviral nucleoside drug combination in inhibiting HIV-reverse transcriptase (RT).
    Periclou AP, Nandy P, Avramis VI.
    In Vivo; 2000 Oct 12; 14(3):377-88. PubMed ID: 10904870
    [Abstract] [Full Text] [Related]

  • 8. Hepatobiliary disposition of 3'-azido-3'-deoxythymidine (AZT) in the rat: effect of phenobarbitone induction.
    Bezek S, Kukan M, Bohov P.
    J Pharm Pharmacol; 1994 Jul 12; 46(7):575-80. PubMed ID: 7996386
    [Abstract] [Full Text] [Related]

  • 9. Differential antiviral activities and intracellular metabolism of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in human cells.
    Mukherji E, Au JL, Mathes LE.
    Antimicrob Agents Chemother; 1994 Jul 12; 38(7):1573-9. PubMed ID: 7526781
    [Abstract] [Full Text] [Related]

  • 10. Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
    Schinazi RF, Sommadossi JP, Saalmann V, Cannon DL, Xie MY, Hart GC, Smith GA, Hahn EF.
    Antimicrob Agents Chemother; 1990 Jun 12; 34(6):1061-7. PubMed ID: 2393266
    [Abstract] [Full Text] [Related]

  • 11. In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.
    Takasawa K, Terasaki T, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Apr 12; 281(1):369-75. PubMed ID: 9103519
    [Abstract] [Full Text] [Related]

  • 12. Pharmacokinetic evaluation of drug interactions with anti-HIV drugs, II: Effect of 2',3'-dideoxyinosine (ddI) on zidovudine kinetics in monkeys.
    Gallo JM, Finco TS, Swagler AR, Mehta MU, Viswanathan CT, Qian M.
    AIDS Res Hum Retroviruses; 1992 Feb 12; 8(2):277-83. PubMed ID: 1540413
    [Abstract] [Full Text] [Related]

  • 13. Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes.
    Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD.
    Mol Membr Biol; 2001 Feb 12; 18(2):161-7. PubMed ID: 11463208
    [Abstract] [Full Text] [Related]

  • 14. Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro.
    Ijichi K, Fujiwara M, Mori K, Morozumi M, Machida H, Shigeta S, Konno K, Yokota T, Baba M.
    Antiviral Res; 1996 Jun 12; 31(1-2):115-20. PubMed ID: 8793015
    [Abstract] [Full Text] [Related]

  • 15. Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger.
    Meng Q, Su T, O'Neill JP, Walker VE.
    Environ Mol Mutagen; 2002 Jun 12; 39(4):282-95. PubMed ID: 12112380
    [Abstract] [Full Text] [Related]

  • 16. Amino acid phosphoramidate monoesters of 3'-azido-3'-deoxythymidine: relationship between antiviral potency and intracellular metabolism.
    Chang S, Griesgraber GW, Southern PJ, Wagner CR.
    J Med Chem; 2001 Jan 18; 44(2):223-31. PubMed ID: 11170632
    [Abstract] [Full Text] [Related]

  • 17. Cellular metabolism in lymphocytes of a novel thioether-phospholipid-AZT conjugate with anti-HIV-1 activity.
    Kucera GL, Goff CL, Iyer N, Morris-Natschke S, Ishaq KS, Wyrick SD, Fleming RA, Kucera LS.
    Antiviral Res; 2001 May 18; 50(2):129-37. PubMed ID: 11369433
    [Abstract] [Full Text] [Related]

  • 18. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine.
    Von Tungeln LS, Dobrovolsky VN, Bishop ME, Shaddock JG, Heflich RH, Beland FA.
    Mutagenesis; 2004 Jul 18; 19(4):307-11. PubMed ID: 15215330
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine.
    Bridges EG, Faraj A, Sommadossi JP.
    Biochem Pharmacol; 1993 Apr 22; 45(8):1571-6. PubMed ID: 8387298
    [Abstract] [Full Text] [Related]

  • 20. Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.
    Takasawa K, Terasaki T, Suzuki H, Ooie T, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Sep 22; 282(3):1509-17. PubMed ID: 9316866
    [Abstract] [Full Text] [Related]

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