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Journal Abstract Search


295 related items for PubMed ID: 9375254

  • 1.
    ; . PubMed ID:
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  • 2. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.
    Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE.
    Biochemistry; 1996 Dec 03; 35(48):15244-8. PubMed ID: 8952473
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  • 3.
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  • 4. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J, Fu H, Cane DE, Khosla C.
    Biochemistry; 1999 Feb 02; 38(5):1643-51. PubMed ID: 9931032
    [Abstract] [Full Text] [Related]

  • 5. Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei.
    Tang L, Yoon YJ, Choi CY, Hutchinson CR.
    Gene; 1998 Aug 31; 216(2):255-65. PubMed ID: 9729415
    [Abstract] [Full Text] [Related]

  • 6. Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase.
    Weissman KJ, Bycroft M, Cutter AL, Hanefeld U, Frost EJ, Timoney MC, Harris R, Handa S, Roddis M, Staunton J, Leadlay PF.
    Chem Biol; 1998 Dec 31; 5(12):743-54. PubMed ID: 9862800
    [Abstract] [Full Text] [Related]

  • 7. Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum.
    Wilkinson CJ, Frost EJ, Staunton J, Leadlay PF.
    Chem Biol; 2001 Dec 31; 8(12):1197-208. PubMed ID: 11755398
    [Abstract] [Full Text] [Related]

  • 8. Engineered intermodular and intramodular polyketide synthase fusions.
    McDaniel R, Kao CM, Hwang SJ, Khosla C.
    Chem Biol; 1997 Sep 31; 4(9):667-74. PubMed ID: 9331407
    [Abstract] [Full Text] [Related]

  • 9. Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.
    Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJ, Reather JA, Rudd BA, Staunton J, Leadlay PF.
    Chem Biol; 2001 Apr 31; 8(4):329-40. PubMed ID: 11325589
    [Abstract] [Full Text] [Related]

  • 10. Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase.
    Jiralerspong S, Rangaswamy V, Bender CL, Parry RJ.
    Gene; 2001 May 30; 270(1-2):191-200. PubMed ID: 11404016
    [Abstract] [Full Text] [Related]

  • 11. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
    Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C.
    J Am Chem Soc; 2003 May 07; 125(18):5366-74. PubMed ID: 12720450
    [Abstract] [Full Text] [Related]

  • 12. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.
    Ranganathan A, Timoney M, Bycroft M, Cortés J, Thomas IP, Wilkinson B, Kellenberger L, Hanefeld U, Galloway IS, Staunton J, Leadlay PF.
    Chem Biol; 1999 Oct 07; 6(10):731-41. PubMed ID: 10508677
    [Abstract] [Full Text] [Related]

  • 13. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
    Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C.
    Biochemistry; 1997 Feb 18; 36(7):1846-51. PubMed ID: 9048569
    [Abstract] [Full Text] [Related]

  • 14. Origin of starter units for erythromycin biosynthesis.
    Weissman KJ, Bycroft M, Staunton J, Leadlay PF.
    Biochemistry; 1998 Aug 04; 37(31):11012-7. PubMed ID: 9692995
    [Abstract] [Full Text] [Related]

  • 15. Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.
    Böhm I, Holzbaur IE, Hanefeld U, Cortés J, Staunton J, Leadlay PF.
    Chem Biol; 1998 Aug 04; 5(8):407-12. PubMed ID: 9710562
    [Abstract] [Full Text] [Related]

  • 16. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
    Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C.
    Biochemistry; 2004 Nov 09; 43(44):13892-8. PubMed ID: 15518537
    [Abstract] [Full Text] [Related]

  • 17. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
    Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BA, Leadlay PF.
    Chem Biol; 1999 Apr 09; 6(4):189-95. PubMed ID: 10099131
    [Abstract] [Full Text] [Related]

  • 18. Mechanisms of molecular recognition in the pikromycin polyketide synthase.
    Chen S, Xue Y, Sherman DH, Reynolds KA.
    Chem Biol; 2000 Dec 09; 7(12):907-18. PubMed ID: 11137814
    [Abstract] [Full Text] [Related]

  • 19. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
    Gokhale RS, Hunziker D, Cane DE, Khosla C.
    Chem Biol; 1999 Feb 09; 6(2):117-25. PubMed ID: 10021418
    [Abstract] [Full Text] [Related]

  • 20. Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase.
    Luo G, Pieper R, Rosa A, Khosla C, Cane DE.
    Bioorg Med Chem; 1996 Jul 09; 4(7):995-9. PubMed ID: 8831969
    [Abstract] [Full Text] [Related]


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