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104 related items for PubMed ID: 9384259

  • 1. DY-9760e, a novel calmodulin antagonist with cytoprotective action.
    Sugimura M, Sato T, Nakayama W, Morishima Y, Fukunaga K, Omitsu M, Miyamoto E, Shirasaki Y.
    Eur J Pharmacol; 1997 Oct 01; 336(1):99-106. PubMed ID: 9384259
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  • 3. The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.
    Hashiguchi A, Yano S, Morioka M, Hamada J, Shirasaki Y, Kochi M, Fukunaga K.
    J Pharmacol Sci; 2004 Sep 01; 96(1):65-72. PubMed ID: 15359085
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  • 4. 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier permeability after transient focal ischemia.
    Sato T, Morishima Y, Shirasaki Y.
    J Pharmacol Exp Ther; 2003 Mar 01; 304(3):1042-7. PubMed ID: 12604680
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  • 5. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov 01; 33(11):1628-36. PubMed ID: 16049129
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  • 7. Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.
    Hashimoto M, Takada Y, Takeuchi Y, Kasahara J, Hisa H, Shirasaki Y, Fukunaga K.
    J Pharmacol Sci; 2005 Jun 01; 98(2):142-50. PubMed ID: 15937403
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  • 11. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.
    Fukunaga K, Han F, Shioda N, Moriguchi S, Kasahara J, Shirasaki Y.
    Cardiovasc Drug Rev; 2006 Jun 01; 24(2):88-100. PubMed ID: 16961723
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  • 14. DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
    Sugimura M, Takamori H, Fukushi H, Kitano Y, Kanazawa Y, Shirasaki Y.
    Biol Pharm Bull; 2005 Apr 01; 28(4):629-33. PubMed ID: 15802800
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  • 15. Pharmacokinetics and disposition of DY-9760e, a novel calmodulin antagonist, in rats and monkeys.
    Tachibana S, Fujimaki Y, Tachibana M, Tanaka M, Kurata T, Okazaki O, Sudo K.
    Arzneimittelforschung; 2005 Apr 01; 55(3):135-44. PubMed ID: 15819385
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  • 16. Determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e, in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
    Tachibana S, Fukano A, Sudo K, Tanaka M.
    J Chromatogr B Biomed Sci Appl; 1999 Oct 29; 734(1):39-45. PubMed ID: 10574188
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  • 17. DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.
    Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K.
    Cardiovasc Ther; 2009 Oct 29; 27(1):17-27. PubMed ID: 19207476
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  • 19. Protective effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced hemolysis in vitro.
    Nagase Y, Hirata M, Arima H, Tajiri S, Nishimoto Y, Hirayama F, Irie T, Uekama K.
    J Pharm Sci; 2002 Nov 29; 91(11):2382-9. PubMed ID: 12379923
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  • 20. Inhibitory effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced cellular damage: In vitro and in vivo studies.
    Nagase Y, Arima H, Wada K, Sugawara T, Satoh H, Hirayama F, Uekama K.
    J Pharm Sci; 2003 Dec 29; 92(12):2466-74. PubMed ID: 14603492
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