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224 related items for PubMed ID: 9399609

  • 1. Evidence for negative feedback of extracellular methotrexate on blasts of acute lymphoblastic leukemia in vitro.
    Hum MC, Smith AK, Lark RH, Winick NJ, Kamen BA.
    Pharmacotherapy; 1997; 17(6):1260-6. PubMed ID: 9399609
    [Abstract] [Full Text] [Related]

  • 2. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.
    Koizumi S, Curt GA, Fine RL, Griffin JD, Chabner BA.
    J Clin Invest; 1985 Mar; 75(3):1008-14. PubMed ID: 2579975
    [Abstract] [Full Text] [Related]

  • 3. A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia.
    Panetta JC, Yanishevski Y, Pui CH, Sandlund JT, Rubnitz J, Rivera GK, Ribeiro R, Evans WE, Relling MV.
    Cancer Chemother Pharmacol; 2002 Nov; 50(5):419-28. PubMed ID: 12439601
    [Abstract] [Full Text] [Related]

  • 4. Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
    Lingg RM, Hempel G, Rots MG, Van Zantwijk CH, Boos J, Kaspers GJ.
    Cancer Chemother Pharmacol; 2005 Sep; 56(3):322-7. PubMed ID: 15868145
    [Abstract] [Full Text] [Related]

  • 5. Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.
    Göker E, Lin JT, Trippett T, Elisseyeff Y, Tong WP, Niedzwiecki D, Tan C, Steinherz P, Schweitzer BI, Bertino JR.
    Leukemia; 1993 Jul; 7(7):1000-4. PubMed ID: 7686600
    [Abstract] [Full Text] [Related]

  • 6. Time course of methotrexate polyglutamate formation and degradation in the pre-B-leukaemia cell line Nalm6 and in lymphoblasts from children with leukaemia.
    Buchholz B, Frei E, Eisenbarth J, Weigand M, Ludwig R.
    Eur J Cancer; 1996 Nov; 32A(12):2101-7. PubMed ID: 9014752
    [Abstract] [Full Text] [Related]

  • 7. gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
    Longo GS, Gorlick R, Tong WP, Lin S, Steinherz P, Bertino JR.
    Oncol Res; 1997 Nov; 9(5):259-63. PubMed ID: 9306433
    [Abstract] [Full Text] [Related]

  • 8. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R, Bekkenk MW, Rots MG, Pieters R, Mini E, van Zantwijk CH, Veerman AJ, Peters GJ, Jansen G.
    Clin Cancer Res; 1998 Oct; 4(10):2399-410. PubMed ID: 9796971
    [Abstract] [Full Text] [Related]

  • 9. Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
    Dervieux T, Hancock ML, Pui CH, Rivera GK, Sandlund JT, Ribeiro RC, Boyett J, Evans WE, Relling MV.
    Clin Pharmacol Ther; 2003 Jun; 73(6):506-16. PubMed ID: 12811360
    [Abstract] [Full Text] [Related]

  • 10. Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.
    Dervieux T, Hancock M, Evans W, Pui CH, Relling MV.
    Leukemia; 2002 Feb; 16(2):209-12. PubMed ID: 11840287
    [Abstract] [Full Text] [Related]

  • 11. [Primary study on establishment of namalwa 12/MTX resistant cell strain and its mechanism].
    Chen J, Gu LJ, Ying DM, Shen M, Wu HJ.
    Ai Zheng; 2002 Dec; 21(12):1335-40. PubMed ID: 12520743
    [Abstract] [Full Text] [Related]

  • 12. [Separation of methotrexate-polyglutamates by capillary electrophoresis and its application to the measurement of gamma-glutamyl hydrolase activity in human leukemia cells in culture].
    Takemura Y, Kobayashi H, Sekiguchi S.
    Rinsho Byori; 1996 Jan; 44(1):51-6. PubMed ID: 8691640
    [Abstract] [Full Text] [Related]

  • 13. Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
    Kaufman Y, Drori S, Cole PD, Kamen BA, Sirota J, Ifergan I, Arush MW, Elhasid R, Sahar D, Kaspers GJ, Jansen G, Matherly LH, Rechavi G, Toren A, Assaraf YG.
    Cancer; 2004 Feb 15; 100(4):773-82. PubMed ID: 14770434
    [Abstract] [Full Text] [Related]

  • 14. Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.
    Lin JT, Tong WP, Trippett TM, Niedzwiecki D, Tao Y, Tan C, Steinherz P, Schweitzer BI, Bertino JR.
    Leuk Res; 1991 Feb 15; 15(12):1191-6. PubMed ID: 1722550
    [Abstract] [Full Text] [Related]

  • 15. Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.
    Panetta JC, Wall A, Pui CH, Relling MV, Evans WE.
    Clin Cancer Res; 2002 Jul 15; 8(7):2423-9. PubMed ID: 12114448
    [Abstract] [Full Text] [Related]

  • 16. A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro.
    Smith A, Hum M, Winick NJ, Kamen BA.
    Clin Cancer Res; 1996 Jan 15; 2(1):69-73. PubMed ID: 9816092
    [Abstract] [Full Text] [Related]

  • 17. Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Whitehead VM, Vuchich MJ, Cooley L, Lauer SJ, Mahoney DH, Shuster JJ, Payment C, Bernstein ML, Akabutu JJ, Bowen T, Kamen BA, Watson MS, Look AT, Pullen DJ, Camitta B.
    Clin Cancer Res; 1998 Jan 15; 4(1):183-8. PubMed ID: 9516969
    [Abstract] [Full Text] [Related]

  • 18. Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
    Rots MG, Pieters R, Kaspers GJ, van Zantwijk CH, Noordhuis P, Mauritz R, Veerman AJ, Jansen G, Peters GJ.
    Blood; 1999 Feb 01; 93(3):1067-74. PubMed ID: 9920857
    [Abstract] [Full Text] [Related]

  • 19. Comparative analysis of methotrexate polyglutamates in lymphoblast preparations from bone marrow and blood, and the contribution of residual red blood cells.
    Weigand M, Frei E, Graf N, Wiessler M.
    J Cancer Res Clin Oncol; 2000 Jul 01; 126(7):407-11. PubMed ID: 10929763
    [Abstract] [Full Text] [Related]

  • 20. Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
    McGuire JJ, Mini E, Hsieh P, Bertino JR.
    Cancer Res; 1985 Dec 01; 45(12 Pt 1):6395-400. PubMed ID: 2415244
    [Abstract] [Full Text] [Related]

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