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408 related items for PubMed ID: 9405715

  • 1. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
    Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ.
    Proc Natl Acad Sci U S A; 1997 Dec 23; 94(26):14924-9. PubMed ID: 9405715
    [Abstract] [Full Text] [Related]

  • 2. Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes.
    Holmes MC, Kotelevtsev Y, Mullins JJ, Seckl JR.
    Mol Cell Endocrinol; 2001 Jan 22; 171(1-2):15-20. PubMed ID: 11165006
    [Abstract] [Full Text] [Related]

  • 3. Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice.
    Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC.
    Endocrinology; 2001 Jan 22; 142(1):114-20. PubMed ID: 11145573
    [Abstract] [Full Text] [Related]

  • 4. Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1.
    Jamieson PM, Nyirenda MJ, Walker BR, Chapman KE, Seckl JR.
    J Endocrinol; 1999 Jan 22; 160(1):103-9. PubMed ID: 9854182
    [Abstract] [Full Text] [Related]

  • 5. 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?
    Seckl JR.
    Front Neuroendocrinol; 1997 Jan 22; 18(1):49-99. PubMed ID: 9000459
    [Abstract] [Full Text] [Related]

  • 6. Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system.
    Seckl JR, Chapman KE.
    Eur J Biochem; 1997 Oct 15; 249(2):361-4. PubMed ID: 9370341
    [Abstract] [Full Text] [Related]

  • 7. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.
    Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ, Seckl JR.
    J Biol Chem; 2001 Nov 02; 276(44):41293-300. PubMed ID: 11546766
    [Abstract] [Full Text] [Related]

  • 8. 11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells.
    Leckie CM, Welberg LA, Seckl JR.
    J Endocrinol; 1998 Nov 02; 159(2):233-8. PubMed ID: 9795363
    [Abstract] [Full Text] [Related]

  • 9. Pathophysiology of modulation of local glucocorticoid levels by 11beta-hydroxysteroid dehydrogenases.
    Sandeep TC, Walker BR.
    Trends Endocrinol Metab; 2001 Dec 02; 12(10):446-53. PubMed ID: 11701343
    [Abstract] [Full Text] [Related]

  • 10. Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action.
    Seckl JR, Walker BR.
    Endocrinology; 2001 Apr 02; 142(4):1371-6. PubMed ID: 11250914
    [Abstract] [Full Text] [Related]

  • 11. Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.
    Davani B, Khan A, Hult M, Mårtensson E, Okret S, Efendic S, Jörnvall H, Oppermann UC.
    J Biol Chem; 2000 Nov 10; 275(45):34841-4. PubMed ID: 10973946
    [Abstract] [Full Text] [Related]

  • 12. Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions.
    Diaz R, Brown RW, Seckl JR.
    J Neurosci; 1998 Apr 01; 18(7):2570-80. PubMed ID: 9502816
    [Abstract] [Full Text] [Related]

  • 13. Tissue- and temporal-specific regulation of 11beta-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo.
    Jamieson PM, Chapman KE, Seckl JR.
    J Steroid Biochem Mol Biol; 1999 Mar 01; 68(5-6):245-50. PubMed ID: 10416840
    [Abstract] [Full Text] [Related]

  • 14. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes.
    Krozowski Z, Li KX, Koyama K, Smith RE, Obeyesekere VR, Stein-Oakley A, Sasano H, Coulter C, Cole T, Sheppard KE.
    J Steroid Biochem Mol Biol; 1999 Mar 01; 69(1-6):391-401. PubMed ID: 10419017
    [Abstract] [Full Text] [Related]

  • 15. Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.
    Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, Andrew R.
    Invest Ophthalmol Vis Sci; 2000 Jun 01; 41(7):1629-38. PubMed ID: 10845579
    [Abstract] [Full Text] [Related]

  • 16. Enhanced 11beta-hydroxysteroid dehydrogenase type 1 activity in stress adaptation in the guinea pig.
    Quinkler M, Troeger H, Eigendorff E, Maser-Gluth C, Stiglic A, Oelkers W, Bähr V, Diederich S.
    J Endocrinol; 2003 Feb 01; 176(2):185-92. PubMed ID: 12553867
    [Abstract] [Full Text] [Related]

  • 17. 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated.
    Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE.
    J Steroid Biochem Mol Biol; 1998 Mar 01; 64(5-6):251-60. PubMed ID: 9618026
    [Abstract] [Full Text] [Related]

  • 18. In vivo characterization of 11beta-hydroxysteroid dehydrogenase in rat hippocampus using glucocorticoid neuroendangerment as an endpoint.
    Ajilore OA, Sapolsky RM.
    Neuroendocrinology; 1999 Feb 01; 69(2):138-44. PubMed ID: 9986927
    [Abstract] [Full Text] [Related]

  • 19. Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.
    Paterson JM, Seckl JR, Mullins JJ.
    Am J Physiol Regul Integr Comp Physiol; 2005 Sep 01; 289(3):R642-52. PubMed ID: 16105819
    [Abstract] [Full Text] [Related]

  • 20. Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments.
    Yau JL, Noble J, Kenyon CJ, Hibberd C, Kotelevtsev Y, Mullins JJ, Seckl JR.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4716-21. PubMed ID: 11274359
    [Abstract] [Full Text] [Related]

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