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477 related items for PubMed ID: 9427642

  • 1. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
    Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.
    Curr Biol; 1998 Jan 15; 8(2):69-81. PubMed ID: 9427642
    [Abstract] [Full Text] [Related]

  • 2. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
    Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.
    J Biol Chem; 1999 Dec 24; 274(52):37400-6. PubMed ID: 10601311
    [Abstract] [Full Text] [Related]

  • 3. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
    Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.
    Curr Biol; 1997 Oct 01; 7(10):776-89. PubMed ID: 9368760
    [Abstract] [Full Text] [Related]

  • 4. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
    Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.
    Curr Biol; 2000 Apr 20; 10(8):439-48. PubMed ID: 10801415
    [Abstract] [Full Text] [Related]

  • 5. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.
    Belham C, Comb MJ, Avruch J.
    Curr Biol; 2001 Aug 07; 11(15):1155-67. PubMed ID: 11516946
    [Abstract] [Full Text] [Related]

  • 6. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.
    Richards SA, Fu J, Romanelli A, Shimamura A, Blenis J.
    Curr Biol; 2001 Aug 07; 9(15):810-20. PubMed ID: 10469565
    [Abstract] [Full Text] [Related]

  • 7. A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation.
    Zhang MY, Barber DL, Alessi DR, Bell LL, Stine C, Nguyen MH, Beattie BK, Cheung JY, Miller BA.
    Exp Hematol; 2001 Apr 07; 29(4):432-40. PubMed ID: 11301183
    [Abstract] [Full Text] [Related]

  • 8. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
    Kobayashi T, Cohen P.
    Biochem J; 1999 Apr 15; 339 ( Pt 2)(Pt 2):319-28. PubMed ID: 10191262
    [Abstract] [Full Text] [Related]

  • 9. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
    Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR.
    Curr Biol; 1999 Apr 22; 9(8):393-404. PubMed ID: 10226025
    [Abstract] [Full Text] [Related]

  • 10. Multiple independent inputs are required for activation of the p70 S6 kinase.
    Weng QP, Andrabi K, Kozlowski MT, Grove JR, Avruch J.
    Mol Cell Biol; 1995 May 22; 15(5):2333-40. PubMed ID: 7739516
    [Abstract] [Full Text] [Related]

  • 11. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.
    Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K.
    J Biol Chem; 1999 Nov 26; 274(48):34493-8. PubMed ID: 10567431
    [Abstract] [Full Text] [Related]

  • 12. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
    Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L.
    Am J Physiol Endocrinol Metab; 2010 Apr 26; 298(4):E761-9. PubMed ID: 20051528
    [Abstract] [Full Text] [Related]

  • 13. Phosphorylation and activation of p70s6k by PDK1.
    Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
    Science; 1998 Jan 30; 279(5351):707-10. PubMed ID: 9445476
    [Abstract] [Full Text] [Related]

  • 14. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
    Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frödin M.
    J Biol Chem; 1999 Sep 17; 274(38):27168-76. PubMed ID: 10480933
    [Abstract] [Full Text] [Related]

  • 15. Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.
    Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K, Tokunaga C, Shirai Y, Saito N, Gout I, Yonezawa K.
    Genes Cells; 2001 Nov 17; 6(11):1003-15. PubMed ID: 11733037
    [Abstract] [Full Text] [Related]

  • 16. Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.
    Wick MJ, Dong LQ, Riojas RA, Ramos FJ, Liu F.
    J Biol Chem; 2000 Dec 22; 275(51):40400-6. PubMed ID: 11006271
    [Abstract] [Full Text] [Related]

  • 17. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
    Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.
    J Cell Sci; 2005 Nov 01; 118(Pt 21):5023-34. PubMed ID: 16219676
    [Abstract] [Full Text] [Related]

  • 18. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
    Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P.
    Curr Biol; 1997 Apr 01; 7(4):261-9. PubMed ID: 9094314
    [Abstract] [Full Text] [Related]

  • 19. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
    Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR.
    Curr Biol; 1999 Feb 25; 9(4):186-97. PubMed ID: 10074427
    [Abstract] [Full Text] [Related]

  • 20. Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
    Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F.
    Proc Natl Acad Sci U S A; 2000 May 09; 97(10):5089-94. PubMed ID: 10792047
    [Abstract] [Full Text] [Related]

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