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Journal Abstract Search

342 related items for PubMed ID: 9435898

  • 1. Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.
    Njoroge FG, Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK.
    J Med Chem; 1997 Dec 19; 40(26):4290-301. PubMed ID: 9435898
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  • 5. Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.
    Anthony NJ, Gomez RP, Schaber MD, Mosser SD, Hamilton KA, O'Neil TJ, Koblan KS, Graham SL, Hartman GD, Shah D, Rands E, Kohl NE, Gibbs JB, Oliff AI.
    J Med Chem; 1999 Aug 26; 42(17):3356-68. PubMed ID: 10464022
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  • 7. Analogs of 4-(3-bromo-8-methyl-10-methoxy-6,11-dihydro-5H-benzo[5,6]-cyclo hepta[1,2-b]pyridin-11-yl)-1-(4-pyridinylacetyl)piperidine N-oxide as inhibitors of farnesyl protein transferase.
    Afonso A, Kelly J, Weinstein J, James L, Bishop WR.
    Bioorg Med Chem Lett; 1999 Jul 05; 9(13):1875-80. PubMed ID: 10406658
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  • 8. Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.
    Strickland CL, Weber PC, Windsor WT, Wu Z, Le HV, Albanese MM, Alvarez CS, Cesarz D, del Rosario J, Deskus J, Mallams AK, Njoroge FG, Piwinski JJ, Remiszewski S, Rossman RR, Taveras AG, Vibulbhan B, Doll RJ, Girijavallabhan VM, Ganguly AK.
    J Med Chem; 1999 Jun 17; 42(12):2125-35. PubMed ID: 10377218
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  • 9. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
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  • 10. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
    Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, Patel MM, Schmidt RJ, Weller HN, Andahazy ML, Carboni JM, Gullo-Brown JL, Lee FY, Ricca C, Rose WC, Yan N, Barbacid M, Hunt JT, Meyers CA, Seizinger BR, Zahler R, Manne V.
    J Med Chem; 1996 Jan 05; 39(1):224-36. PubMed ID: 8568812
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  • 11. Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.
    Kelly J, Wolin R, Connolly M, Afonso A, James L, Kirshmeier P, Bishop WR, McPhail AT.
    Bioorg Med Chem; 1998 Jun 05; 6(6):673-86. PubMed ID: 9681133
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  • 12. Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential.
    Tanaka R, Rubio A, Harn NK, Gernert D, Grese TA, Eishima J, Hara M, Yoda N, Ohashi R, Kuwabara T, Soga S, Akinaga S, Nara S, Kanda Y.
    Bioorg Med Chem; 2007 Feb 01; 15(3):1363-82. PubMed ID: 17127066
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  • 13. Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.
    Kaminski JJ, Rane DF, Snow ME, Weber L, Rothofsky ML, Anderson SD, Lin SL.
    J Med Chem; 1997 Dec 05; 40(25):4103-12. PubMed ID: 9406600
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  • 15. Analogues of 1-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta [1,2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase.
    Afonso A, Weinstein J, Kelly J, Wolin R, Rosenblum SB, Connolly M, Guzi T, James L, Carr D, Patton R, Bishop WR, Kirshmeier P, Liu M, Heimark L, Chen KJ, Nomeir AA.
    Bioorg Med Chem; 1999 Sep 05; 7(9):1845-55. PubMed ID: 10530932
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  • 17. Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice.
    Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Li Z, Dell J, Lipari P, Malkowski M, Prioli N, Rossman RR, Korfmacher WA, Nomeir AA, Lin CC, Mallams AK, Doll RJ, Catino JJ, Girijavallabhan VM, Kirschmeier P, Bishop WR.
    Cancer Chemother Pharmacol; 1999 Sep 05; 43(1):50-8. PubMed ID: 9923541
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  • 18. Discovery and structure-activity relationships of novel piperidine inhibitors of farnesyltransferase.
    Nara S, Tanaka R, Eishima J, Hara M, Takahashi Y, Otaki S, Foglesong RJ, Hughes PF, Turkington S, Kanda Y.
    J Med Chem; 2003 Jun 05; 46(12):2467-73. PubMed ID: 12773050
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  • 19. Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase.
    Augeri DJ, O'Connor SJ, Janowick D, Szczepankiewicz B, Sullivan G, Larsen J, Kalvin D, Cohen J, Devine E, Zhang H, Cherian S, Saeed B, Ng SC, Rosenberg S.
    J Med Chem; 1998 Oct 22; 41(22):4288-300. PubMed ID: 9784104
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  • 20. Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.
    Taveras AG, Aki C, Chao J, Doll RJ, Lalwani T, Girijavallabhan V, Strickland CL, Windsor WT, Weber P, Hollinger F, Snow M, Patton R, Kirschmeier P, James L, Liu M, Nomeir A.
    J Med Chem; 2002 Aug 29; 45(18):3854-64. PubMed ID: 12190309
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