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Journal Abstract Search

227 related items for PubMed ID: 9484499

  • 1. Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.
    Sugihara H, Fukushi H, Miyawaki T, Imai Y, Terashita Z, Kawamura M, Fujisawa Y, Kita S.
    J Med Chem; 1998 Feb 12; 41(4):489-502. PubMed ID: 9484499
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  • 2. Novel non-peptide GPIIb/IIIa antagonists: synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl] acetic acids.
    Kitamura S, Fukushi H, Miyawaki T, Kawamura M, Terashita Z, Sugihara H, Naka T.
    Chem Pharm Bull (Tokyo); 2001 Mar 12; 49(3):258-67. PubMed ID: 11253914
    [Abstract] [Full Text] [Related]

  • 3. New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: orally active series of N-alkylated amidines with a 6,6-bicyclic template.
    Okumura K, Shimazaki T, Aoki Y, Yamashita H, Tanaka E, Banba S, Yazawa K, Kibayashi K, Banno H.
    J Med Chem; 1998 Oct 08; 41(21):4036-52. PubMed ID: 9767641
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  • 4. Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives.
    Kitamura S, Fukushi H, Miyawaki T, Kawamura M, Konishi N, Terashita Z, Naka T.
    J Med Chem; 2001 Jul 19; 44(15):2438-50. PubMed ID: 11448226
    [Abstract] [Full Text] [Related]

  • 5. Antagonism of the GPIIb/IIIa receptor with the nonpeptidic molecule BIBU52: inhibition of platelet aggregation in vitro and antithrombotic efficacy in vivo.
    Guth BD, Seewaldt-Becker E, Himmelsbach F, Weisenberger H, Müller TH.
    J Cardiovasc Pharmacol; 1997 Aug 19; 30(2):261-72. PubMed ID: 9269956
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  • 6. Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
    Kawamura M, Imura Y, Moriya N, Kita S, Fukushi H, Sugihara H, Nishikawa K, Terashita Z.
    J Pharmacol Exp Ther; 1996 Apr 19; 277(1):502-10. PubMed ID: 8613960
    [Abstract] [Full Text] [Related]

  • 7. Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist.
    Moritani Y, Sato K, Shigenaga T, Hisamichi N, Ichihara M, Akamatsu S, Suzuki Ki, Nii T, Kaku S, Kawasaki T, Matsumoto Y, Inagaki O, Tomioka K, Yanagisawa I.
    Eur J Pharmacol; 2002 Mar 29; 439(1-3):43-52. PubMed ID: 11937091
    [Abstract] [Full Text] [Related]

  • 8. Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin.
    Krysko AA, Krysko OL, Kabanova TA, Andronati SA, Kabanov VM.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4444-6. PubMed ID: 20598885
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  • 12. Design and synthesis of a series of indole glycoprotein IIb/IIIa inhibitors.
    Grumel V, Mérour JY, Lesur B, Giboulot T, Frydman A, Guillaumet G.
    Eur J Med Chem; 2002 Jan 01; 37(1):45-62. PubMed ID: 11841874
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  • 13. Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 1. The selection of naphthalene derivatives.
    Ono S, Inoue Y, Yoshida T, Ashimori A, Kosaka K, Imada T, Fukaya C, Nakamura N.
    Chem Pharm Bull (Tokyo); 1999 Dec 01; 47(12):1685-93. PubMed ID: 10748713
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  • 14. New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent.
    Badorc A, Bordes MF, de Cointet P, Savi P, Bernat A, Lalé A, Petitou M, Maffrand JP, Herbert JM.
    J Med Chem; 1997 Oct 10; 40(21):3393-401. PubMed ID: 9341914
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  • 16. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity.
    Mousa SA, Forsythe M, Lorelli W, Bozarth J, Xue CB, Wityak J, Sielecki TM, Olson RE, DeGrado W, Kapil R, Hussain M, Wexler R, Thoolen MJ, Reilly TM.
    Coron Artery Dis; 1996 Oct 10; 7(10):767-74. PubMed ID: 8970768
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  • 17. GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
    Hayashi Y, Katada J, Harada T, Tachiki A, Iijima K, Takiguchi Y, Muramatsu M, Miyazaki H, Asari T, Okazaki T, Sato Y, Yasuda E, Yano M, Uno I, Ojima I.
    J Med Chem; 1998 Jun 18; 41(13):2345-60. PubMed ID: 9632368
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  • 18. Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa (alphaIIb/beta3) receptor-directed platelet inhibition.
    Li YF, Spencer FA, Becker RC.
    Am Heart J; 2001 Aug 18; 142(2):204-10. PubMed ID: 11479455
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  • 19. Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood: activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonists.
    Cook NS, Zerwes HG, Tapparelli C, Powling M, Singh J, Metternich R, Hagenbach A.
    Thromb Haemost; 1993 Sep 01; 70(3):531-9. PubMed ID: 8259560
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