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141 related items for PubMed ID: 9485372

  • 1. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
    Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C.
    Biochemistry; 1998 Feb 24; 37(8):2263-70. PubMed ID: 9485372
    [Abstract] [Full Text] [Related]

  • 2. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
    Walter J, Grünberg J, Schindzielorz A, Haass C.
    Biochemistry; 1998 Apr 28; 37(17):5961-7. PubMed ID: 9558331
    [Abstract] [Full Text] [Related]

  • 3. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997 Apr 28; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 4. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S, Haass C, Steiner H.
    J Neurochem; 2005 Jul 28; 94(1):57-62. PubMed ID: 15953349
    [Abstract] [Full Text] [Related]

  • 5. Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
    Van Gassen G, De Jonghe C, Pype S, Van Criekinge W, Julliams A, Vanderhoeven I, Woodrow S, Beyaert R, Huylebroeck D, Van Broeckhoven C.
    Neurobiol Dis; 1999 Oct 28; 6(5):376-91. PubMed ID: 10527805
    [Abstract] [Full Text] [Related]

  • 6. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 28; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 7. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
    Knappenberger KS, Tian G, Ye X, Sobotka-Briner C, Ghanekar SV, Greenberg BD, Scott CW.
    Biochemistry; 2004 May 25; 43(20):6208-18. PubMed ID: 15147205
    [Abstract] [Full Text] [Related]

  • 8. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
    Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.
    Traffic; 2006 Mar 25; 7(3):354-64. PubMed ID: 16497228
    [Abstract] [Full Text] [Related]

  • 9. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
    Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C.
    J Biol Chem; 1998 Feb 06; 273(6):3205-11. PubMed ID: 9452432
    [Abstract] [Full Text] [Related]

  • 10. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 11. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 08; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 12. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
    Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C.
    Proc Natl Acad Sci U S A; 1997 May 13; 94(10):5349-54. PubMed ID: 9144240
    [Abstract] [Full Text] [Related]

  • 13. Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.
    Tomidokoro Y, Ishiguro K, Igeta Y, Matsubara E, Kanai M, Shizuka M, Kawarabayashi T, Harigaya Y, Kawakatsu S, Ii K, Ikeda M, St George-Hyslop PH, Hirai S, Okamoto K, Shoji M.
    Biochem Biophys Res Commun; 1999 Mar 24; 256(3):512-8. PubMed ID: 10080929
    [Abstract] [Full Text] [Related]

  • 14. Presenilins upregulate functional K+ channel currents in mammalian cells.
    Malin SA, Guo WX, Jafari G, Goate AM, Nerbonne JM.
    Neurobiol Dis; 1998 Apr 24; 4(6):398-409. PubMed ID: 9666479
    [Abstract] [Full Text] [Related]

  • 15. Presenilins and Alzheimer's disease: the role of A beta 42.
    Eckman CB.
    J Neural Transm Suppl; 1998 Apr 24; 53():181-4. PubMed ID: 9700656
    [Abstract] [Full Text] [Related]

  • 16. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.
    J Neurochem; 2006 Jan 24; 96(1):218-27. PubMed ID: 16305624
    [Abstract] [Full Text] [Related]

  • 17. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ.
    Neurobiol Dis; 1998 Aug 24; 5(2):107-16. PubMed ID: 9746908
    [Abstract] [Full Text] [Related]

  • 18. Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
    Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.
    J Neurosci Res; 2004 Feb 01; 75(3):417-28. PubMed ID: 14743455
    [Abstract] [Full Text] [Related]

  • 19. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 01; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 20. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
    Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C.
    J Biol Chem; 1998 Nov 27; 273(48):32322-31. PubMed ID: 9822712
    [Abstract] [Full Text] [Related]

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