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Journal Abstract Search

172 related items for PubMed ID: 9488721

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  • 3. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
    Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M.
    J Biol Chem; 1995 Feb 10; 270(6):2550-6. PubMed ID: 7852317
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  • 5. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
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  • 9. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
    Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD.
    Osteoarthritis Cartilage; 1998 May 01; 6(3):214-28. PubMed ID: 9682788
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  • 10. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.
    Biochem J; 1999 Nov 15; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
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  • 12. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
    Fosang AJ, Last K, Neame PJ, Murphy G, Knäuper V, Tschesche H, Hughes CE, Caterson B, Hardingham TE.
    Biochem J; 1994 Dec 01; 304 ( Pt 2)(Pt 2):347-51. PubMed ID: 7998967
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  • 13. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov 01; 19(6):533-43. PubMed ID: 11068207
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  • 14. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
    Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L.
    Biochem J; 1995 Aug 15; 310 ( Pt 1)(Pt 1):337-43. PubMed ID: 7544117
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  • 15. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
    Tortorella MD, Malfait AM, Deccico C, Arner E.
    Osteoarthritis Cartilage; 2001 Aug 15; 9(6):539-52. PubMed ID: 11520168
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  • 16. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
    Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS.
    J Clin Invest; 1997 Jul 01; 100(1):93-106. PubMed ID: 9202061
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  • 17. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA.
    J Biol Chem; 1992 Sep 25; 267(27):19470-4. PubMed ID: 1326552
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  • 18. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R.
    Biochem J; 1995 Apr 01; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
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  • 19. Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan.
    Ilic MZ, Robinson HC, Handley CJ.
    J Biol Chem; 1998 Jul 10; 273(28):17451-8. PubMed ID: 9651333
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  • 20. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.
    Fosang AJ, Last K, Stanton H, Weeks DB, Campbell IK, Hardingham TE, Hembry RM.
    J Biol Chem; 2000 Oct 20; 275(42):33027-37. PubMed ID: 10882746
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